Maurice Wilhelm | Researchain

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Featured researches published by Maurice Wilhelm.

Bioorganic & Medicinal Chemistry Letters | 1999

Piperidine-renin inhibitors compounds with improved physicochemical properties

Rolf Güller; Alfred Binggeli; Volker Breu; Daniel Bur; Walter Fischli; Georges Hirth; Christian Jenny; Manfred Kansy; Francois Montavon; Marcel Muller; Christian Oefner; Heinz Stadler; Eric Vieira; Maurice Wilhelm; Wolfgang Wostl; Hans Peter Märki

Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D(pH 7.4) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.

Archive | 1996

New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency

Alfred Binggeli; Volker Breu; Daniel Bur; Walter Fischli; Rolf Gueller; Georges Hirth; Hans-Peter Maerki; Marcel Mueller; Christian Oefner; Heinz Stadler; Eric Vieira; Maurice Wilhelm; Wolfgang Wostl

Archive | 2000

1,2,4,5-Tetrahydro-benzo[D]azepin derivatives

Geo Adam; Alfred Binggeli; Hans-Peter Marki; Vincent Mutel; Maurice Wilhelm; Wolfgang Wostl

Archive | 1999

Piperidine derivatives having renin inhibiting activity

Alfred Binggeli; Volker Breu; Daniel Bur; Walter Fischli; Rolf Güller; Georges Hirth; Hans-Peter Marki; Marcel Muller; Christian Oefner; Heinz Stadler; Eric Vieira; Maurice Wilhelm; Wolfgang Wostl

Archive | 2000

Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors

Geo Adam; Alfred Binggeli; Hans-Peter Maerki; Vincent Mutel; Maurice Wilhelm; Wolfgang Wostl

Archive | 2002

Pyrimidine, triazine and pyrazine derivatives as glutamate receptors

Alfred Binggeli; Hans-Peter Maerki; Thierry Masquelin; Vincent Mutel; Maurice Wilhelm; Wolfgang Wostl

Archive | 2001

Tetrahydro-heterocycloazepinyl pyrimidine derivatives

Alfred Binggeli; Hans-Peter Maerki; Vincent Mutel; Wolfgang Wostl; Maurice Wilhelm

Archive | 2001

Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine

Alfred Binggeli; Hans-Peter Maerki; Vincent Mutel; Maurice Wilhelm; Wolfgang Wostl

Archive | 2002

Pyrimidine, pyrazine and triazine derivatives

Alfred Binggeli; Hans-Peter Maerki; Thierry Masquelin; Vincent Mutel; Maurice Wilhelm; Wolfgang Wostl

Archive | 2000

1,2,4,5-TETRAHYDRO-BENZ[d]AZEPINES

Geo Adam; Alfred Binggeli; Hans-Peter Maerki; Vincent Mutel; Maurice Wilhelm; Wolfgang Wostl; アルフレート・ビンゲッリ; ヴァンサン・ミュッテル; ヴォルフガング・ヴォステル; ゲオ・アダム; ハンス−ペーター・メルキ; モーリス・ヴィレルム

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