Mauro Maldonato

Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: Association with higher body mass index

Loss of circadian patterning of metabolism-related functions seems to play a role in the pathogenesis of obesity; therefore, it is reasonable to hypothesize that the functional 3111T/C single nucleotide polymorphism (SNP) of the (Circadian locomotor output cycles kaput) CLOCK gene may have a part in the genetic susceptibility to obesity. The aim of this study was to assess the frequencies of 3111T/C CLOCK gene SNP in overweight/obese subjects with or without binge eating disorder (BED) as compared to normal weight healthy controls. A total of 284 Caucasian subjects, including 92 normal weight healthy subjects and 192 overweight/obese patients (107 with BED) participated into the study. Genotype and allele frequencies did not significantly differ between normal weight controls and overweight/obese patients with and/or without BED. However, overweight/obese patients carrying the CC genotype had significantly higher values of body mass index (BMI) as compared to those carrying the CT and/or TT genotypes. Moreover, obese class III individuals had a significantly higher frequency of both the CC genotype and the C allele as compared to individuals with BMI<40 kg/m(2). Present findings show for the first time that the 3111T/C SNP of the CLOCK gene is not associated to human obesity and/or BED, but it seems to predispose obese individuals to a higher BMI.

The Predictive Brain

During the lengthy and complex process of human evolution our ancestors had to adapt to extremely testing situations in which survival depended on making rapid choices that subjected muscles and the body as a whole to extreme tension. In order to seize a prey traveling at speeds that could reach 36 km per hour Homo sapiens had just thousandths of a second in which to anticipate the right moment and position himself before the prey arrived. He also had to prepare the appropriate gesture, tensing his muscles and overcoming the resistance determined by body weight. While we are no longer faced with an environment that is anything so threatening, our brain continues to use these mechanisms day in day out to save time and energy, enabling us to avoid situations of danger, sense in advance the intentions of an interlocutor, and more besides. In this article we set out to show that our brain is not only a reactive mechanism, capable of reacting quickly to the stimuli that arrive from the external environment, but is above all a pro-active mechanism that allows us to make hypotheses, anticipate the consequences of actions, and formulate expectations: in short, to wrong foot an adversary.

Undecidable Decisions: Rationality Limits and Decision-making Heuristics

In this article the theoretic evolution and the empirical-experimental efforts that have led to the affirmation of the bounded/procedural rationality paradigm are discussed. Moreover, the debate on supporters of the “optimization” approach and supporters of the “bounded/procedural rationality” approach is traced, highlighting the irreconcilability of these two approaches and, in retort, a solid defense against a merely “reductionist” attempt of the innovative context of the Simonian theory. Critically going over the debate on decision dynamics, it becomes clear how, due to the uncertain nature of rational processes, it is impossible to establish the decision-making best way. The imperfect character of individual choice is explained by how the decider identifies a solution that appears satisfying in that moment due to cognitive and temporal limits.

Making Decisions under Uncertainty Emotions, Risk and Biases

The difficulty in deciding and facing up to uncertainty is not only linked to the inadequacy of the architecture of our minds but also to an ‘external’ model of uncertainty which does not correspond to the way in which our mind naturally functions. New conceptual paradigms and new programmes for experimental research are called for in order to redefine the role of internal and external restrictions on human action (resources and available information, limitations on calculation ability, on the capacity of memory, cognitive styles, gender differences and so on). All this should be contemplated in a more general theoretical framework – natural logic – based not on metaphysical assumptions but on the concrete evidence provided by cognitive neurosciences.

TOWARD AN EVOLUTIONARY THEORY OF RATIONALITY

Since the dawn of time, humankinds singular ability to make decisions has allowed human beings to face innumerable environmental challenges and complex evolutionary dynamics. Environmental pressures are not so urgent anymore, comparing to our ancestors. Nonetheless, the number of decisions that contemporary humans are called to make is very high. During the last three centuries, the change from normative to descriptive theories, from formal to natural logic, from substantive to limited rationality has allowed us to explain how many of the decisional strategies are coherent with the functioning of the cognitive economy of our species, even if they are limited and fallible.

How to Make Decisions in An Uncertain World: Heuristics, Biases, and Risk Perception

From the seventies onward a large quantity of theoretical and empirical studies have investigated the heuristic principles and cognitive strategies that individuals use to deal with risky and uncertain situations. This research has shown how the explicative and predictive shortcomings of normative risk analysis depend in many respects on undervaluing the continuous interaction between the individual and the environment. There are factors that, day by day, represent significant obstacles to decision making.

On the significance of speech pauses in depressive disorders: Results on read and spontaneous narratives

This paper investigates whether and how depressive disorders affect speech and in particular timing strategies for speech pauses (empty and filled pauses, as well as, phoneme lengthening). The investigation is made exploiting read and spontaneous narratives . The collected data are from 24 subjects, divided into two groups (depressed and control) asked to read a tale, as well as, spontaneously report on their daily activities. Ten different frequency and duration measures for pauses and clauses are proposed and have been collected using the PRAAT software on the speech recordings produced by the participants. A T-Student test for independent samples was applied on the collected frequency and duration measures in order to ascertain whether significant differences between healthy and depressed speech measures are observed. In the “spontaneous narrative” condition, depressed patients exhibited significant differences in: the average duration of their empty pauses, the average frequency, and the average duration of their clauses. In the read narratives, only the average pause’s frequency of the clauses was significantly lower in the depressed subjects with respect to the healthy ones. The results suggest that depressive disorders affect speech quality and speech production through pause and clause durations, as well as, clause quantities. In particular, the significant differences in clause quantities (observed both in the read and spontaneous narratives), suggest a strong general effect of depressive symptoms on cognitive and psychomotor functions. Depressive symptoms produce changes in the planned timing of pauses, even when reading, modifying the timing of pausing strategies.

Neuronal symphonies: Musical improvisation and the centrencephalic space of functional integration

Musical improvisation is a sophisticated activity in which a performer realizes, real-time, melodic, and rhythmic sequences in harmony with those from other musicians. The study of musical improvisation helps one to understand not only the cognition of creativity, but also the complex neuronal basis of executive functions, the relation between conscious and unconscious action, and even more. So far, the prevailing models, founded on the brain imaging method, have focused on the connection between the cortical areas and their cognitive processes. Little attention, on the other hand, has been given to the huge variety of subcortical activities, especially in the basal ganglia. This fundamental subcortical component, through its implicit procedures and the role it plays in memory, is responsible to produce new information all the time, allowing the prefrontal cortex to transform a huge and disordered amount of data in explicit creative acts. The basal ganglia are strongly related to the activation of chemical signals generated by dissonance or lack of symmetry between perception and expectation, participating even in the responses to environmental demands according to the circumstances. Thus, they interact with the frontal cortex and with the limbic system, playing a key role in planning and selecting appropriate actions and in decision making. In this text, we try to explain in which sense improvisation is connected to the processes of executive functions, to creativity and to the integrated activity of cortical–subcortical areas controlling the free flow of ideas and to expressive spontaneity. Eventually, we purpose a model according to which structure (improvisational field) and process (improvisational time) take part at the centrencephalic space of functional integration, which, through both competing and cooperating dynamics, gives way to spontaneous composition.

FROM NEURON TO CONSCIOUSNESS: FOR AN EXPERIENCE-BASED NEUROSCIENCE

Up until only a few decades ago, not many scholars recognized scientific dignity in the problem of consciousness. In the last few years this scenario has changed. The rapid development of non-invasive research techniques that explore cerebral functions has not only increased our knowledge on the correlations between mental processes and cerebral structures, but it has fed our hopes for the possibility of facing the ancient and elusive question about the mind–brain relationship with a new way of thinking. The meeting between neurosciences and phenomenology represents one of the most promising frontiers of current research. Neurophenomenology, a paradigm of research inaugurated by the Chilean neuroscientist Francisco Varela, tries to indicate a remedy to the various explicatory philosophical and scientific gaps, establishing a methodological and epistemological bridge between the so-called phenomenological reports in “first person” and the scientific evidence in “third person,” incorporating the experience on neurodynamic levels in an explicit and rigorous way and, above all, avoiding every alternative in the direction of any form of ontological reduction.

Consciência da temporalidade e temporalidade da consciência

La investigacion cientifica ha descuidado la relacion tiempo-conciencia. La temporalidad es origen y estructura de la conciencia. La experiencia temporal no puede ser abordada con claridad con el unico instrumento de la investigacion empirica. Para intentar comprenderla, se solicita una indagacion conceptual interdisciplinaria. El presente articulo busca trazar un panel de las indagaciones mas relevantes en ese ambito, comenzando por la reflexion fenomenologica husserliana sobre la estructura y la conciencia del tiempo, para llegar a los mas recientes estudios empiricos que buscan mapear las areas y las estructuras cerebrales en el origen de una determinada experiencia. Entre tanto, el estudio indica la inadecuacion de descripciones meramente instrumentales y senala la necesidad de aprehender la naturaleza del pasaje del nivel neuronal para el nivel mental para explicar el fenomeno de la conciencia. Es preciso, para esto, investigar los complejos mecanismos de realizacion de la conciencia, que tienen como fundamento la temporalidad inmanente, el flujo de vida en el cual surge la conciencia originaria del tiempo. Para eso, se hace necesario alcanzar un punto de observacion privilegiado, capaz de conceptualmente abarcar las variadas facetas de la concretizacion de la conciencia; el autor afirma la necesidad de una investigacion interdisciplinaria, englobando por lo menos, filosofia, psicologia y neurofisiologia.