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European Journal of Pharmacology | 1977

Selective inhibition of noradrenaline and serotonin uptake by C 49802-B-Ba and CGP 6085 A.

Peter C. Waldmeier; Peter A. Baumann; Max Wilhelm; Raymond Bernasconi; L. Maitre

The effects of two new compounds, 1-(1-methylamino-2-hydroxy-3-propyl)-dibenzo[b,e]bicyclo[2,2,2]octadiene-HCl (C 49802-B-Ba) and 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl (CGP 6085 A), on noradrenaline (NA) and serotonin (5-HT) uptake were investigated in different test systems, CGP 6085 A is a very potent and selective inhibitor of 5-HT uptake in rat brain (ED50 1-4 mg/kg p.o., depending on test system). Doses up to 1000 mg/kg p.o. did not inhibit NA uptake. C 49802-B-Ba is a potent and selective inhibitor of NA uptake in rat brain (ED50 5-10 mg/kg p.o. depending on test system) and heart (ED50 1.5 mg/kg p.o.). At 300 mg/kg p.o., this compound caused no inhibition of 5-HT uptake.


Archive | 1964

Gamma-amino-beta-(para-halophenyl)-butyric acids and their esters

Heinrich Keberle; J. W. Faigle; Max Wilhelm


Archive | 1975

Cycloalkylureido phenoxy propanolamines

Max Wilhelm


Archive | 1968

1 - (isopropylamino)-2-hydroxy-3-(alkenyloxyphenoxy) - propanes and the salts thereof

Hans Ulrich Daeniker; Karl Schenker; Paul Schmidt; Max Wilhelm


Archive | 1965

5-nitrothiazolyl-dioxo-diazacycloalkanes

Ernst Sury; Kurt Eichenberger; Max Wilhelm; Paul Schmidt


Archive | 1975

9-(2-Hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes and salts thereof

Max Wilhelm; Raymond Bernasconi; Angelo Storni; Dieter Beck; Karl Schenker


Archive | 1976

PHARMACEUTICAL PREPARATION USING 9-(2-HYDROXY-3-AMINO-PROPYL)-9,10-DIHYDRO-9,10-ETHANO-ANTHRACENES AS ANTIDEPRESSANTS

Max Wilhelm; Raymond Bernasconi; Angelo Storni; Dieter Beck; Karl Schenker


Archive | 1967

N-PHENYL - 5 - (DIMETHYLSULFAMOYL)-ANTHRANILIC ACID,ESTERS AND AMIDES THEREOF

Paul Schmidt; Kurt Eichenberger; Alberto Rossi; Max Wilhelm


Archive | 1964

DERIVATIVES OF 7 - AMINO - CEPHALO-SPORANIC ACID AND PROCESS FOR THEIR MANUFACTURE

Hans Bickel; Rolf Bosshardt; Bruno Fechtig; Karl Schenker; Jakob Urech; Max Wilhelm


Archive | 1967

1-isopropylamino-2-hydroxy-3-(2'-isopropoxy-phenoxy)-propane and salts thereof

Karl Schenker; Ulrich Daeniker Hans; Paul Schmidt; Max Wilhelm

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