Maynard W. McNeil

Antifungal Properties of 2-Alkenoic Acids and 2-Bromo Alkanoic Acids

The antifungal activity of homologous series of 2-alkenoic and 2-bromo alkanoic acids was determined against Aspergillus niger, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes and compared with data on analogous alkanoic and 2-fluoro alkanoic acids. The fungitoxicity of all of the series of compounds was determined by chain length, pH of the medium, and presence or absence of adsorbents such as serum albumin. The order of toxicity on a molecular basis, by using a scale where the most active series is 1.0, is 2-bromo alkanoic acids (1.0) > 2-fluoro alkanoic acids (1.2) > alkanoic acids (1.4) > 2-alkenoic acids (2.5).

Stability constants of some sterically hindered bis-(8-quinolinolato)copper(II) complexes

Abstract Stability constants of several bis(8-quinolinolato) copper(II) complexes substituted in the 7-, 2,7-, and 2,5-positions were determined by potentiometric titration in 75%(v/v) ethanol-water solution. The presence of a methyl group in the 2-position or halo atom in the 7-position causes steric hindrance between the ligands, resulting in non-planarity of the copper(II) complexes. This is evidenced by the non-additivity of the hindrance in the 2- and 7-positions.