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Dive into the research topics where Mayra Carrijo Rochael is active.

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Featured researches published by Mayra Carrijo Rochael.


Anais Brasileiros De Dermatologia | 2011

Síndrome de Sweet: estudo de 73 casos, com ênfase nos achados histopatológicos

Mayra Carrijo Rochael; Luciana Pantaleão; Enoi Aparecida Guedes Vilar; Luciana Helena Zacaron; Eduardo Quelhas Spada; Marcus Henrique de Sousa Brito Xavier; Karla Strong Rodrigues

BACKGROUND Sweets syndrome refers to a set of cutaneous, systemic and histopathological alterations that occur in response to different stimuli, in a similar way to that occurring in erythema nodosum, erythema multiforme and leukocytoclastic vasculitis. The syndrome has been described in association with conditions such as infections, pregnancy, the use of certain medications and malignancy. OBJECTIVES To evaluate the clinical and histopathological alterations occurring in this syndrome and to assess the association between these alterations and other conditions. METHODS A retrospective study of 73 cases was conducted, evaluating data on the microscopic examination of skin lesions, as well as clinical and laboratory data. RESULTS The majority of the patients were female (83.0%), white (49.2%) and between 30 and 60 years of age (73.8%). The principal alterations found were: erythymatous plaques (76.9%), papules (43.0%), pseudo-vesiculation (PV) (38.4%) and target lesions (18.5%). With respect to the associated conditions, upper respiratory tract infections (15.4%) and the use of medication (10.8%) were the most common. Other associations, albeit represented by only one case each, were: Hodgkins lymphoma, pregnancy, ulcerative colitis, polycythemia vera and lupus erythematosus in a patient with acquired immune deficiency syndrome (AIDS). The principal microscopic findings were: neutrophils with leukocytoclasia (98.6%), collagen degeneration (87.7%), edema (74.0%) and PV (38.4%). The presence of eosinophils (41.1%) ranged from rare to abundant and was usually unrelated to the use of medication. Inflammatory infiltrate reached the deep epidermal layer in 47.9% of cases and panniculitis was found in 80.0% of cases in which the hypodermis was affected (10 cases). CONCLUSIONS In general, these findings are in agreement with results published in the literature, emphasizing the frequent finding of eosinophils unrelated to drug use, panniculitis and the rare association with Hodgkins lymphoma. This is the fifth report of an association between Sweets syndrome and Hodgkins disease.


Lasers in Surgery and Medicine | 2013

Transepidermal Retinoic Acid Delivery Using Ablative Fractional Radiofrequency Associated With Acoustic Pressure Ultrasound for Stretch Marks Treatment

Maria Claudia Almeida Issa; Luiza Erthal de Britto Pereira Kassuga; Natalia Stroligo Chevrand; Lívia do Nascimento Barbosa; Ronir Raggio Luiz; Luciana Pantaleão; Enoi Aparecida Guedes Vilar; Mayra Carrijo Rochael

Striae distensae (SD) treatment still remains a therapeutic challenge to dermatologists. Ablative fractional laser and radiofrequency (RF) enhance skin‐drug permeability for SD treatment.


Anais Brasileiros De Dermatologia | 2006

Perfil histopatológico e imuno-histoquímico da leishmaniose tegumentar americana com ênfase nos dendrócitos dérmicos FXIIIa+

Maria Luisa Duarte; Mayra Carrijo Rochael

BACKGROUND: Mucocutaneous leishmaniasis is a parasitic infectious disease with relevant immunological aspects. OBJECTIVE: To study the histopathological and immunohistochemical aspects of 21 leishmaniasis tegumentary biopsies. METHODS: Polyclonal anti-Leishmania antibody was used to confirm the presence of Leishmania amastigotes. Histopathological classification comprised I-V standard groups. The immunopathological pattern was evaluated as to the presence of FXIIIa+ dermal dendrocytes, CD1a+ Langerhans cells, CD68+ macrophages, CD20+ B lymphocytes, and CD3+ T lymphocytes. The FXIIIa+ cells were quantified and compared to specimens of normal skin obtained from unexposed areas. The other cells were counted in a semi-quantitative way. The number of FXIIIa+ cells was statistically analyzed using the Mann-Whitney test. RESULTS: Among the histopathological groups, I and II standards prevailed. The FXIIIa+ cells were observed for different aspects and compared to normal skin, without significant statistical differences (p = 0.157). There was no relation between the amount of CD1a+, CD68+, CD20+ and CD3+ cells when compared to each other or to FXIIIa+ cells. CONCLUSION: There was no difference between the number of FXIIIa+ cells in leishmaniasis and in normal skin. However, more studies are needed in order to understand the role of FXIIIa+ cells in leishmaniasis.


Jornal Brasileiro De Patologia E Medicina Laboratorial | 2003

Análise histopatológica comparativa entre líquen plano oral e cutâneo

Silvia Elena Navas-Alfaro; Eliene Carvalho da Fonseca; Maria Angelica Guzman-Silva; Mayra Carrijo Rochael

BACKGROUND: Lichen planus is a relatively common chronic inflammatory disease affecting skin and mucous membranes, separately or together. It frequently involves the oral cavity, with or without concomitant cutaneous compromise. Microscopically, while skin presents well characteristic aspects, oral mucosa can present variations related to local characteristics of the mucosa in the oral cavity. OBJECTIVES: To compare histopathological alterations of oral lichen planus and cutaneous lichen planus with the study of the inflammatory infiltrate components. METHODS: 59 biopsies (29 of OLP and 30 of CLP), formalin-fixed, paraffin-embedded were studied. Semi-quantitative analysis of both epidermal and dermal alterations was performed using the hematoxylin-eosin and periodic acid-Schiff stains. RESULTS: For CLP the classic aspects of orthokeratosis, wedge shaped hypergranulosis and saw tooth rete ridges were observed. Such aspects differ from those of OLP in which orthokeratosis and thickened granular layer happen less frequently; instead, acquisition of those layers is observed in places where they are usually absent. Basal cell vacuolar alteration and effacement of the epithelium-conjunctive limit prevailed in both locations (skin and oral mucosa) and lymphocytes and histiocytes were the inflammatory cells present in all cases. CONCLUSIONS: Classic alterations as compact orthokeratosis, wedge shaped hypergranulosis, saw tooth rete ridges acanthosis and basal cell vacuolar alteration associates to lymphocytes in superficial band-like pattern are diagnostic of CLP. However, for OLP, the particular own characteristics of oral mucosa in the biopsied place should be considered; also, subtler alterations of horny (light orthokeratosis) and granular (presence where it is usually absent) layers should be valued . Wedge shape pattern of hypergranulosis is rarely seen in OLP. Saw tooth rete ridges acanthosis is not frequently seen in OLP, however, basal cell vacuolar alteration is always present and associated to band-like lymphocitic infiltrate. Plasma cells can accompany lymphocytes in OLP, however, they are absent in CLP.


Anais Brasileiros De Dermatologia | 2003

Granuloma anular: distribuição tecidual dos dendrócitos dérmicos fator XIIIa+, das células dérmicas trombomodulina+ e de macrófagos CD68+

Claudia Regina Wanderley Soub; Mayra Carrijo Rochael; Tullia Cuzzi

BACKGROUND: A subgroup of macrophage related dermal cells expresses the pro-coagulation factor XIIIa, while others express the anti-coagulation cofactor thrombomodulin. These cells can be involved in inflammatory and reparative tissue events. OBJETIVES: We investigated the participation of factor XIIIa+ dermal cells and thrombomodulin+ (TM+) dermal cells in the histopathological picture of granuloma annulare which is characterized by collagen necrobiosis and macrophagic infiltrate. METHODS: The histopathological picture of granuloma annulare observed in 23 skin biopsies was classified according to presence of complete or incomplete collagen degeneration and distribution of dermal infiltrate. Factor XIIIa+ dermal dendrocytes and thrombomodulin+ dermal cells were recognized by specific antibodies applied in immunohistochemical protocols; a macrophage marker (CD68) was also used. Distribution of distinct cell subsets were observed and semiquantitative analysis performed. RESULTS: Factor XIIIa+ dendrocytes were rarely detected in the lesion while thrombomodulin+ and CD68+ cells represented a considerable part of cell infiltrate. They were seen at its periphery (palisade arrangement), among degenerated collagen or diffusely distributed. A tendency was noted for association between higher semiquantification of thrombomodulin+ cells and both lower semiquantification of FXIIIa+ dendrocytes and histological type II. Dermal dendrocyte hyperplasia around the lesion was detected. CONCLUSION: The different tissue distribution of the FXIIIa+ cells and TM+ cells could reflect their distinct and complementary roles in the recovery of dermal tissue and in the lesion evolutive process in granuloma annulare.


Anais Brasileiros De Dermatologia | 2011

Síndrome stiff skin: relato de caso

Adriana Gutstein da Fonseca Amorim; Marcia Kalil Aidé; Sandra Maria Barbosa Durães; Mayra Carrijo Rochael

Sindrome stiff skin e doenca rara, esclerodermiforme, de etiologia desconhecida, caracterizada por endurecimento petreo da pele, hipertricose leve e limitacao da mobilidade articular. Nao ha tratamento efetivo ate o momento. Exercicios e reabilitacao sao importantes para manter a qualidade de vida do paciente. Os autores apresentam caso de um menino de dois anos de idade com endurecimento cutâneo progressivo desde os oito meses de idade e restricao secundaria da mobilidade articular, diagnosticado como Sindrome stiff skin


Anais Brasileiros De Dermatologia | 2006

Edema hemorrágico agudo da infância

Júlio César Gomes Silveira; Ada Lobato Quattrino; Rodrigo Bragança; Mayra Carrijo Rochael

Infantile acute hemorrhagic edema is a rare leukocytoclastic vasculitis that affects children under 2 years of age. The disease has a benign outcome usually with no complications or recurrence. We report the case of a 17-month-old girl with clinical and histopathological findings that are typical of infantile acute hemorrhagic edema.


Anais Brasileiros De Dermatologia | 2015

Spitz nevi in the classic histopathological pattern - lamb in wolf`s clothing

Gustavo Costa Verardino; Mayra Carrijo Rochael

Spitz nevus is a benign melanocytic lesion and also one of the main differential diagnosis of melanoma. A descriptive and retrospective study of surgical specimens from patients with a diagnosis of Spitz nevus was conducted at two institutions in Niterói - RJ. 32 cases were analyzed. The most frequent histological subtype was compound (60 %), with a predominance of epithelioid cells (17 cases - 53%). Pagetoid spread was observed in 21 cases (68%). Maturation of melanocytes was present in 13 cases (81%). Kamino bodies were found in eight cases (25%). Atypical melanocytes were present in 18 cases (56%). Mitoses were present in 11 cases (34%). Detailed knowledge of the classical form of Spitz nevi is essential for the differential diagnosis with melanoma. However, no single criterium is definitive in the differential diagnosis between Spitz nevus and melanoma.


Anais Brasileiros De Dermatologia | 2010

Calcinose cútis distrófica universal associada a lúpus eritematoso sistêmico: um caso exuberante

Ana Paula Gonçalves Carocha; Daniel Moscon Torturella; Gimelly Ribeiro Barreto; Rogério Ribeiro Estrella; Mayra Carrijo Rochael

Calcinosis cutis is an uncommon disease of unclear pathophysiology that is often disabling. It is characterized by the formation of calcium deposits in the skin or subcutaneous tissue. It is classified into four subtypes: dystrophic, metastatic, idiopathic or iatrogenic. It may be seen in a variety of systemic diseases such as hyperparathyroidism and hypervitaminosis D, but is most commonly found in dermatomyositis, scleroderma and overlap syndromes and is a rare complication of systemic lupus erythematosus. The management of secondary complications and the success of therapy are constant challenges in the follow-up of these cases.


Jornal Brasileiro De Patologia E Medicina Laboratorial | 2008

Estudo da espessura da regressão como fator prognóstico nos melanomas cutâneos finos

Luciana Pantaleão; Mayra Carrijo Rochael

BACKGROUND: The diagnosis of thin cutaneous malignant melanomas has been increasingly more frequent. These lesions, initially associated with excellent prognosis, have presented recurrence or metastases and sometimes have been fatal. Many variables have been studied and, although none of them has explained this behaviour, regression and its possible negative impact have been focused on recently. According to some authors, late regression bears major relevance in the prognosis. OBJECTIVE: To correlate the maximum regression thickness of thin cutaneous malignant melanomas with disease-free survival time. MATERIALS AND METHOD: Retrospective study of 84 cases of thin cutaneous malignant melanomas. The criteria of Kang et al. (1993) for identification and evolutionary classification (early, intermediate and late) of the regression were applied. RESULTS: Regression (in any phase) was observed in 70 out of 84 thin cutaneous malignant melanomas (83.3%), and 30 cases (35.7%) showed late regression. The maximum regression thickness measurement ranged from 0.16 to 1.53 mm. Disease-free survival time ranged from 17 days to 108 months. Five cases (5.9%) had an unfavorable outcome, from which three were in situ melanomas. There was no correlation between the studied variables (p > 0.05). DISCUSSION: The meaning of regression in thin cutaneous malignant melanomas is controversial, probably due to the different methods applied in the few studies carried out about the subject and the wide variety of size and composition of the samples. There is no medical consensus as to a standardized regression measurement system, which partially explains the controversial results obtained to date. CONCLUSIONS: There was no statistical correlation between regression thickness in thick cutaneous melanomas and disease-free survival time (p > 0.05). Future studies with wider samples may contribute to a better understanding of this phenomenon.

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Luciana Pantaleão

Federal Fluminense University

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Ada Lobato Quattrino

Federal Fluminense University

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Rodrigo Bragança

Federal Fluminense University

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Fabiana Rabe Carvalho

Federal Fluminense University

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