Mayuko Ishikawa

Feasibility of using an automatic blood return system compared with the manual method during a power interruption

キーワード:自動,返血,透析,停電 〈要旨〉 【目的】バックアップオンライン返血機能を搭載したニプロ社製透析用患者監視装置 NCV‒3の利便性を通常の手動 での生理食塩水を用いた返血と比較検討した.【方法】試験デザインはクロスオーバー法を採用した.NCV‒3のオ ンライン返血と生理食塩水を用いた手動返血を,透析部臨床工学技士スタッフ 4名がそれぞれ 8回ずつ独力でシ ミュレーションし,返血開始から終了までの時間を計測した.【結果】バックアップオンライン自動返血の所要時間 は個人差がなく,初回 222.0±5.0秒であり,手動返血にかかる時間(344.0±14.1秒,p=0.0005)と比較して有意 に短かった.手動返血では実施回数を重ねるにつれ全員の所要時間は徐々に短縮し 8回目の所要時間は 236.5±9.6 秒となり,自動返血とほぼ互角となった.【結論】バックアップオンライン自動返血は,人手をかけず緊急時の返血 業務を素早く行うことができる.

Out-of-hospital cardiac arrest related to coronary arterial spasm in three elderly patients with no obstructive coronary artery disease

Coronary spastic angina (CSA) is relatively more common in young people than in elderly people. Here, we present three cases of elderly male patients who experienced out-of-hospital cardiac arrest (OHCA) likely due to coronary spasm-induced ventricular fibrillation (Vf) from 2013 to 2016. After defibrillation, emergency coronary arteriography demonstrated severe coronary vasospasm that resolved following intracoronary infusion of nitroglycerin in the right coronary arteries in all three patients, with no organic obstructive lesion in the coronary arteries after nitroglycerin infusion. Case 1 was a 74-year-old patient with a past history of unstable angina and no organic obstructive lesion on coronary arteriography. He was administered oral amlodipine, isosorbide mononitrate, and nicorandil. He survived an OHCA and underwent implantable cardioverter defibrillator (ICD) implantation on day 57. Case 2 was a 71-year-old patient without prior CSA, who suddenly lost consciousness during a break after tennis. Vf was reversed to sinus rhythm by defibrillation in the ambulance. He died of multi-organ failure on day 7. Case 3 was a 66-year-old patient diagnosed with multi-vessel CSA by coronary arteriography with acetylcholine provocation test. He survived an OHCA associated with inferior acute myocardial infarction, rejected ICD implantation, and has not had a chest pain attack or syncope since discharge. <Learning objective: This article reports a case series of out-of-hospital cardiac arrest (OHCA) likely due to coronary spastic angina (CSA) in the presence of non-obstructive coronary artery disease in elderly patients. Although CSA is associated with an increased risk of OHCA, little is known regarding clinical risk factors, the effectiveness of implanted defibrillators for the secondary prevention of cardiac arrest, or the long-term prognosis of elderly CSA patients who survive OHCA.>.

275 EFFECT OF EPLERENONE OR VALSARTAN ON ENDOTHELIAL PROGENITOR CELLS IN ISCHEMIC HINDLIMB

Objectives: We investigate whether the selective mineralocorticoid receptor (MR) antagonist eplerenone or valsartan improves endothelial progenitor cells (EPCs) function in rat hindlimb ischemia. Design and Methods: Unilateral hindlimb ischemia was surgically induced in Wistar rats. After induced ischemia, rats received eplerenone (30 mg/kg/day), valsartan (3 mg/kg/day), or vehicle for 3 weeks. Peripheral blood mononuclear cells were isolated, subjected to flow cytometric analysis to determine the number of circulating EPCs, cultured to assay EPC colony formation, and subjected to a migration chamber assay to evaluate EPCs migration. Results: Blood perfusion by Laser Doppler Image was significantly higher in eplerenone than in vehicle. Capillary density by Isolectin-B4 stained of ischemic muscle was significantly increased in eplerenone compared with vehicle. Eplerenone significantly increased the number, colony formation and migration of EPCs. Levels of endothelial nitric oxide synthase and angiogenic factor such as vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 protein expression by Western blot were significantly higher in eplerenone than in vehicle. Eplerenone significantly decreased the NAD(P)H oxidase p22phox, p47phox, gp91phox and MR expression and expression of aldosterone effector kinase Sgk1. These effects of eplerenone are similar extent as valsartan. Conclusions: These findings suggest that eplerenone and valsartan improves the proliferation and function of EPCs in rat hindlimb ischemia, and that eplerenone and valsartan may provide a novel and effective therapeutic strategy for the repair of cardiovascular diseases.