Mayura Sevala
University of North Carolina at Chapel Hill
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Publication
Featured researches published by Mayura Sevala.
American Journal of Physiology-lung Cellular and Molecular Physiology | 2009
Giorgio Zanotti; Monica Casiraghi; John B. Abano; Jason R. Tatreau; Mayura Sevala; Hilary Berlin; Susan S. Smyth; William K. Funkhouser; Keith Burridge; Scott H. Randell; Thomas M. Egan
Toll-like receptors (TLRs) of the innate immune system contribute to noninfectious inflammatory processes. We employed a murine model of hilar clamping (1 h) with reperfusion times between 15 min and 3 h in TLR4-sufficient (C3H/OuJ) and TLR4-deficient (C3H/HeJ) anesthetized mice with additional studies in chimeric and myeloid differentiation factor 88 (MyD88)- and TLR4-deficient mice to determine the role of TLR4 in lung ischemia-reperfusion injury. Human pulmonary microvascular endothelial monolayers were subjected to simulated warm ischemia and reperfusion with and without CRX-526, a competitive TLR4 inhibitor. Functional TLR4 solely on pulmonary parenchymal cells, not bone marrow-derived cells, mediates early lung edema following ischemia-reperfusion independent of MyD88. Activation of MAPKs and NF-kappaB was significantly blunted and/or delayed in lungs of TLR4-deficient mice as a consequence of ischemia-reperfusion injury, but edema development appeared to be independent of activation of these signaling pathways. Pretreatment with a competitive TLR4 inhibitor prevented edema in vivo and reduced actin cytoskeletal rearrangement and gap formation in pulmonary microvascular endothelial monolayers subjected to simulated warm ischemia and reperfusion. In addition to its well-accepted role to alter gene transcription, functioning TLR4 on pulmonary parenchymal cells plays a key role in very early and profound pulmonary edema in murine lung ischemia-reperfusion injury. This may be due to a novel mechanism: regulation of endothelial cell cytoskeleton affecting microvascular endothelial cell permeability.
The Annals of Thoracic Surgery | 2006
Thomas M. Egan; John Haithcock; William Nicotra; Giovanna Koukoulis; Hidetoshi Inokawa; Mayura Sevala; Paul L. Molina; William K. Funkhouser; Burton J. Mattice
Journal of Heart and Lung Transplantation | 2006
Thomas M. Egan; Steven C. Hoffmann; Mayura Sevala; John Sadoff; Scott A. Schlidt
The Annals of Thoracic Surgery | 2006
Hidetoshi Inokawa; Mayura Sevala; William K. Funkhouser; Thomas M. Egan
The Journal of Thoracic and Cardiovascular Surgery | 2006
Seiki Takashima; Giovanna Koukoulis; Hidetoshi Inokawa; Mayura Sevala; Thomas M. Egan
Journal of Heart and Lung Transplantation | 2005
Giovanna Koukoulis; Ray A. Caldwell; Hidetoshi Inokawa; Brian Button; Mayura Sevala; Johnnie D. Lyles; Seiki Takashima; John Blackwell; Scott H. Randell; Thomas M. Egan
Journal of Surgical Research | 2005
Seiki Takashima; Scott A. Schlidt; Giovanna Koukoulis; Mayura Sevala; Thomas M. Egan
Journal of Heart and Lung Transplantation | 2006
G. Zanotti; Scott H. Randell; William K. Funkhouser; Mayura Sevala; Thomas M. Egan
Archive | 2015
Thomas M. Egan; Randy M. Becker; John J. Lemasters; Ya-Wen Chen; Kuo Chu Hwang; Cheng-Chieh Yen; Yih-Loong Lai; Susan S. Smyth; William K. Funkhouser; Keith Burridge; Scott H. Randell; Monica Casiraghi; John B. Abano; Jason R. Tatreau; Mayura Sevala
Archive | 2007
Hidetoshi Inokawa; Mayura Sevala; William K. Funkhouser; Thomas M. Egan