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Dive into the research topics where Mayura Sevala is active.

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Featured researches published by Mayura Sevala.


American Journal of Physiology-lung Cellular and Molecular Physiology | 2009

Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema

Giorgio Zanotti; Monica Casiraghi; John B. Abano; Jason R. Tatreau; Mayura Sevala; Hilary Berlin; Susan S. Smyth; William K. Funkhouser; Keith Burridge; Scott H. Randell; Thomas M. Egan

Toll-like receptors (TLRs) of the innate immune system contribute to noninfectious inflammatory processes. We employed a murine model of hilar clamping (1 h) with reperfusion times between 15 min and 3 h in TLR4-sufficient (C3H/OuJ) and TLR4-deficient (C3H/HeJ) anesthetized mice with additional studies in chimeric and myeloid differentiation factor 88 (MyD88)- and TLR4-deficient mice to determine the role of TLR4 in lung ischemia-reperfusion injury. Human pulmonary microvascular endothelial monolayers were subjected to simulated warm ischemia and reperfusion with and without CRX-526, a competitive TLR4 inhibitor. Functional TLR4 solely on pulmonary parenchymal cells, not bone marrow-derived cells, mediates early lung edema following ischemia-reperfusion independent of MyD88. Activation of MAPKs and NF-kappaB was significantly blunted and/or delayed in lungs of TLR4-deficient mice as a consequence of ischemia-reperfusion injury, but edema development appeared to be independent of activation of these signaling pathways. Pretreatment with a competitive TLR4 inhibitor prevented edema in vivo and reduced actin cytoskeletal rearrangement and gap formation in pulmonary microvascular endothelial monolayers subjected to simulated warm ischemia and reperfusion. In addition to its well-accepted role to alter gene transcription, functioning TLR4 on pulmonary parenchymal cells plays a key role in very early and profound pulmonary edema in murine lung ischemia-reperfusion injury. This may be due to a novel mechanism: regulation of endothelial cell cytoskeleton affecting microvascular endothelial cell permeability.


The Annals of Thoracic Surgery | 2006

Ex vivo evaluation of human lungs for transplant suitability

Thomas M. Egan; John Haithcock; William Nicotra; Giovanna Koukoulis; Hidetoshi Inokawa; Mayura Sevala; Paul L. Molina; William K. Funkhouser; Burton J. Mattice


Journal of Heart and Lung Transplantation | 2006

Nitroglycerin Reperfusion Reduces Ischemia-Reperfusion Injury in Non-Heart-Beating Donor Lungs

Thomas M. Egan; Steven C. Hoffmann; Mayura Sevala; John Sadoff; Scott A. Schlidt


The Annals of Thoracic Surgery | 2006

Ex-Vivo Perfusion and Ventilation of Rat Lungs From Non-Heart-Beating Donors Before Transplant

Hidetoshi Inokawa; Mayura Sevala; William K. Funkhouser; Thomas M. Egan


The Journal of Thoracic and Cardiovascular Surgery | 2006

Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non-heart-beating donors.

Seiki Takashima; Giovanna Koukoulis; Hidetoshi Inokawa; Mayura Sevala; Thomas M. Egan


Journal of Heart and Lung Transplantation | 2005

Trends in Lung pH and po2 After Circulatory Arrest: Implications for Non-Heart-Beating Donors and Cell Culture Models of Lung Ischemia-Reperfusion Injury

Giovanna Koukoulis; Ray A. Caldwell; Hidetoshi Inokawa; Brian Button; Mayura Sevala; Johnnie D. Lyles; Seiki Takashima; John Blackwell; Scott H. Randell; Thomas M. Egan


Journal of Surgical Research | 2005

Isoproterenol Reduces Ischemia-Reperfusion Lung Injury Despite β-Blockade1

Seiki Takashima; Scott A. Schlidt; Giovanna Koukoulis; Mayura Sevala; Thomas M. Egan


Journal of Heart and Lung Transplantation | 2006

30: Critical role of toll-like receptor (TLR) 4 in lung ischemia-reperfusion injury (IRI)

G. Zanotti; Scott H. Randell; William K. Funkhouser; Mayura Sevala; Thomas M. Egan


Archive | 2015

nucleotide changes in the circulation-arrested rat lung

Thomas M. Egan; Randy M. Becker; John J. Lemasters; Ya-Wen Chen; Kuo Chu Hwang; Cheng-Chieh Yen; Yih-Loong Lai; Susan S. Smyth; William K. Funkhouser; Keith Burridge; Scott H. Randell; Monica Casiraghi; John B. Abano; Jason R. Tatreau; Mayura Sevala


Archive | 2007

Before Transplant Ex-Vivo Perfusion and Ventilation of Rat Lungs From Non-Heart-Beating Donors

Hidetoshi Inokawa; Mayura Sevala; William K. Funkhouser; Thomas M. Egan

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Thomas M. Egan

University of North Carolina at Chapel Hill

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William K. Funkhouser

University of North Carolina at Chapel Hill

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Scott H. Randell

University of North Carolina at Chapel Hill

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Jason R. Tatreau

University of North Carolina at Chapel Hill

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Monica Casiraghi

University of North Carolina at Chapel Hill

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John B. Abano

University of North Carolina at Chapel Hill

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John Blackwell

University of North Carolina at Chapel Hill

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