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Publication
Featured researches published by Mee-Kyung Kim.
Journal of Life Science | 2008
Yun-Hee Shon; Mee-Kyung Kim; Jung-Sun Jang; Eun-Jung Jung; Kyung-Soo Nam
Deep sea water was tested for cancer chemopreventive activity by measuring the activities of naphthoflavone cytochrome P 450 1A2 (CYP 1A2), quinone reductase (QR) and glutathione-S-transferase (GST), glutathione (GSH) levels, and ornithine decarboxylase (ODC) activity. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of ) showed a hardness-dependent inhibition of CYP 1A2 activity. QR and GST activities were induced about fold with the treatment of deep sea water in murine hepatoma Hepa 1clc7 cells. In addition GSH levels were increased fold in a hardness range of . The deep sea water showed 20.3 and 35.0% inhibition of 12-O- tetradecanoylphorbol-13-a-cetate (TPA)-induced ODC activity at hardness 800 and 1,000, respectively. Therefore, deep sea water is worth further investigation with respect to cancer chemoprevention or therapy.
Journal of Life Science | 2008
Yun-Hee Shon; Mee-Kyung Kim; Kyung-Soo Nam
Deep sea water from the East sea was tested for breast cancer chemoprevention and metastasis by measuring the activities of cytochrome P450 1A1 and aromatase, invasiveness, and activity and expression of matrix metalloproteinase (MMP)-9 in breast MDA-MB-231 cancer cell. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of 100∼1,000) showed a hardness-dependent inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced cytochrome P450 1A1 activity. Deep sea water showed 27.1, 45.4 and 51.9% inhibition of microsomal aromatase activity at the hardness of 600, 800 and 1,000, respectively. In addition deep sea water inhibited not only the invasiveness of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MDA-MB-231 cells through matrigel-coated membrane in a hardness-dependent manner but also the activity and expression of MMP-9 in MDA-MB-231 cell.
Journal of Microbiology and Biotechnology | 2007
Kyung-Soo Nam; Mee-Kyung Kim; Yun-Hee Shon
Journal of Microbiology and Biotechnology | 2007
Kyung-Soo Nam; Mee-Kyung Kim; Yun-Hee Shon
Journal of the Korean Physical Society | 2008
Kyung-Soo Nam; Mee-Kyung Kim; Yun-Hee Shon
한국생명과학회 심포지움 | 2006
Yun-Hee Shon; Hyun-Jung Cho; Mee-Kyung Kim; Kyung-Soo Nam
한국생명과학회 심포지움 | 2006
Kyung-Soo Nam; Mee-Kyung Kim; Yun-Hee Shon
한국생명과학회 심포지움 | 2006
Yun-Hee Shon; Hyun-Jung Cho; Eun-Jung Jung; Mee-Kyung Kim; Kyung-Soo Nam
Journal of Marine Bioscience and Biotechnology | 2006
Kyung-Soo Nam; Mee-Kyung Kim; Hyun-Jung Cho; Yun-Hee Shon
Journal of Marine Bioscience and Biotechnology | 2006
Kyung-Soo Nam; Mee-Kyung Kim; Hyun-Jung Cho; Yun-Hee Shon