Meenakshi Arora

Pharmaceutical Polymeric Controlled Drug Delivery Systems

Drug delivery systems have taken a great impetus to deliver a drug to the diseased lesions. Although this concept is not new great progress has recently been made in the treatment of a variety of diseases. A suitable carrier is needed to deliver a suitable and sufficient amount of the drug to a targeted point, hence, various kinds of formulations are being constantly developed. This paper reviews the present state of art regarding the synthetic methods and characterization of nanoparticles, the suitability of polymeric systems for various drugs, drug loading and drug release properties of various systems such as nanoparticles, hydrogels, microspheres, film and membranes, tablets, etc. The purpose of this review is to summarize the available information so that it will be helpful to beginners and serve as a useful tool for active researchers involved in this area.

Handbook of Natural Zeolites

Description: Handbook of Natural Zeolites provides a comprehensive and updated summary of all important aspects of natural zeolites science and technology. The e-book contains four sections covering the relevant scientific background, established technologies, recent discoveries and future perspectives. All 28 chapters in this handbook are presented by highly respected scientists and leaders in natural zeolites science and include extensive references. The text in this e-book is supported by excellent figures and tables. As a result, novices and established scientists alike will find this comprehensive volume a great resource for years to come.

Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner

At the organismic level, exposure to radiation can produce taste aversion (CTA) learning and emesis, which have been proposed as behavioral endpoints that are mediated by harmful effects of radiations on peripheral systems, primarily the gastrointestinal system. Thus, the aim of the present investigation was to study the gastroprotective action of hydroalcoholic extract of zingiber rhizome (Zingiber officinale Rosc.) against radiation-induced conditioned taste aversion (CTA) in both male and female species of animals, for testing its potential as a behavioral radioprotector. Administration of zingiber extract 1 h before 2-Gy gamma-radiation was significantly effective in blocking the saccharin avoidance response, with 200 and 250 mg/kg b.wt. i.p., being the most effective doses for male and female rats, respectively. A comparison of the efficacy of zingiber extract with two antiemetic drugs, ondansteron and dexamethasone, revealed that the extract rendered comparable protection against radiation-induced CTA. Our experiments also confirmed the existence of sex dichotomy (i.e., the sex of animal greatly influenced response towards radiation exposure) in relation to behavioral responses (CTA) or differential metabolism. The observed gender variations were hypothesized to be a result of hormonal fluctuations and differences in pharmacological parameters in male and female rats. To correlate the mechanism of action, the free-radical-scavenging potential of zingiber extract to scavenge hydroxyl ion and nitric oxide was also tested, in cell-free system and a concentration of 1000 microg/ml, was found to be the most potent, which has been proposed as one the many activities assisting in its overall ability to modulate radiation-induced taste aversion. The results demonstrate that Z. officinale possesses antioxidant, radioprotective and neuromodulatory properties that can be effectively utilized for behavioral radioprotection and for efficiently mitigating radiation-induced CTA in both males and females species.

Arsenic testing field kits: some considerations and recommendations.

In recent years field test kits have been largely used to identify arsenic (As) levels in contaminated water sources in Bangladesh, West Bengal (India), and elsewhere in the world to establish whether or not the water is safe. Most of the kits are based on the reaction of arsine gas with some chemical agent to form a coloured complex; the intensity of the colour is compared visually with a colour-coded chart or measured electronically to calculate the concentration of As in the water sample. In this paper, a step-wise review is presented of the analytical process used in the most commonly available As field test kits and the associated shortcomings of each of these kits. We also identify the research gaps for future work to enhance the accuracy and reliability of test results produced by these kits.

Zingiber officinale Rosc. modulates gamma radiation-induced conditioned taste aversion.

The aim of the present study was to investigate the neurobehavioral protective efficacy of a hydroalcoholic extract of ginger (Zingiber officinale Rosc.) in mitigating gamma radiation-induced conditioned taste aversion in Sprague-Dawley rats. Administration of Zingiber extract 1 h before 2-Gy gamma irradiation was effective in blocking the saccharin avoidance response for 5 post-treatment observational days, both in a dose- and time-dependent manner, with 200 mg/kg b.w. i.p. being the most effective dose. Highest saccharin intake in all the groups was observed on the fifth post-treatment day. The potential of ginger extract to inhibit lipid peroxidation induced by radiation (2 Gy) and ascorbate-ion stress in brain homogenate and its ability to scavenge highly reactive superoxide anions were evaluated. The 1000-microg/ml and 2000-microg/ml concentration of ginger extract showed the highest efficiency in scavenging free radicals and in inhibiting lipid peroxidation. The lipid peroxidation and superoxide-anion scavenging ability of the extract further supports its radioprotective properties. The results clearly establish the neurobehavioral efficacy of ginger extract and the antioxidant properties appear to be a contributing factor in its overall ability to modulate radiation-induced conditioned taste aversion. Ginger extract has tremendous potential for clinical applications in mitigation of radiation-induced emesis in humans.

Suitability of Grey Water Recycling as decentralized alternative water supply option for Integrated Urban Water Management

The imbalance between water demand and supply has become a significant concern of human life as demand is increasing exponentially. With growing urbanization, this imbalance has become more acute in urban areas. So implementation of alternative water supply options has become an inevitable need for urban water management. Grey water and black water recycling is one of the most reliable options to reduce urban water demand. Both centralized and decentralized recycling systems are used based on available site, economic condition and treatment system facilities. But decentralized systems should be given priority for grey water recycling to reduce burden on centralized system and save transportation cost. This paper has proposed a strategy of recycling grey water separately from black water by using decentralized approach. There are various kinds of grey water treatment systems around the world. A review of those processes has been done to identify the best suited processes at household and community level. Septic tank, constructed wetland and intermittent sand filter are identified as the most suitable processes for decentralized treatment due to the simple operation and maintenance facilities as well as cost effectiveness of these systems. Some case studies have been presented to demonstrate the successful execution and impressive performance of these systems on cluster level. Though the systems contain some disadvantages, effective uses of these systems can be made with proper management, execution of awareness program and strict monitoring practices among users. I. BACKGROUND Sustainable development and human and ecosystem health is on threat because of continuous depletion and pollution of freshwater (Furumai 2008). With the increasing rate of population growth urban water demand is rising worldwide (Sharma & Vairavamoorthy 2009). Furthermore, the capital and operation and maintenance costs of treatment plants, allocation and transport cost are increasing which make the condition worst (Sharma & Vairavamoorthy 2009). With more than half of humanity urbanized, an integrated and holistic view to the water supply and demand needs to be obtained as early as possible. The key concern is to create a proper balance between water demand and supply with respect to the social, economic and environmental overheads (Fattahi & Fayyaz 2009). To overcome the increasing water demand, a very simple strategy is to follow the 3R options- Reduce, Reuse and Recycle. Sustainability of integrated urban water management system is largely dependent on how well these water supply options are put into operation. Rainwater harvesting, stormwater harvesting are the alternative water supply options for reusing water and wastewater like black water, grey water recycling are the options for recycling for urban water management. 1.1 Recycling system Demand management, using of rainwater and stormwater are climate dependent and non reliable sources. Where wastewater recycling is another resource which is reliable, reduce the water demand and decrease the amount of waste to be treated. Therefore, wastewater recycling or management is gradually getting importance in the low and middle income countries where public health and environment is on a stake because of inadequate wastewater management. Appropriate recycling system of wastewater reduces water cost as well as increase the food security and public health. 1.2 Decentralized treatment system Moving toward more sustainable urban water practices involves moving away from the incompetence

Mint oil (Mentha spicata Linn.) offers behavioral radioprotection: a radiation-induced conditioned taste aversion study.

Mentha spicata Linn. (mint), a herb well known for its gastroprotective properties in the traditional system of medicine has been shown to protect against radiation‐induced lethality, and recently its constituents have been found to possess calcium channel antagonizing properties. The present study examined the behavioral radioprotective efficacy of mint oil (obtained from Mentha spicata), particularly in mitigating radiation‐induced conditioned taste aversion (CTA), which has been proposed as a behavioral endpoint that is mediated by the toxic effects of gamma radiation on peripheral systems, primarily the gastrointestinal system in the Sprague‐Dawley rat model. Intraperitoneal administration of Mentha spicata oil 10% (v/v), 1 h before 2 Gy gamma radiation, was found to render significant radioprotection against CTA (p < 0.05), by blocking the saccharin avoidance response within 5 post‐treatment observational days, with the highest saccharin intake being observed on day 5. This finding clearly demonstrates that gastroprotective and calcium channel antagonizing properties of Mentha spicata can be effectively utilized in preventing radiation‐induced behavioral changes. Copyright

A novel substance flow analysis model for analysing multi-year phosphorus flow at the regional scale

Achieving sustainable management of phosphorus (P) is crucial for both global food security and global environmental protection. In order to formulate informed policy measures to overcome existing barriers of achieving sustainable P management, there is need for a sound understanding of the nature and magnitude of P flow through various systems at different geographical and temporal scales. So far, there is a limited understanding on the nature and magnitude of P flow over multiple years at the regional scale. In this study, we have developed a novel substance flow analysis (SFA) model in the MATLAB/Simulink® software platform that can be effectively utilized to analyse the nature and magnitude of multi-year P flow at the regional scale. The model is inclusive of all P flows and storage relating to all key systems, subsystems, processes or components, and the associated interactions of P flow required to represent a typical P flow system at the regional scale. In an annual time step, this model can analyse P flow and storage over as many as years required at a time, and therefore, can indicate the trends and changes in P flow and storage over many years, which is not offered by the existing regional scale SFA models of P. The model is flexible enough to allow any modification or the inclusion of any degree of complexity, and therefore, can be utilized for analysing P flow in any region around the world. The application of the model in the case of Gippsland region, Australia has revealed that the model generates essential information about the nature and magnitude of P flow at the regional scale which can be utilized for making improved management decisions towards attaining P sustainability. A systematic reliability check on the findings of model application also indicates that the model produces reliable results.

Next Generation Precision-Polyesters Enabling Optimization of Ligand–Receptor Stoichiometry for Modular Drug Delivery

The success of receptor-mediated drug delivery primarily depends on the ability to optimize ligand-receptor stoichiometry. Conventional polyesters such as polylactide (PLA) or its copolymer, polylactide-co-glycolide (PLGA), do not allow such optimization due to their terminal functionality. We herein report the synthesis of 12 variations of the PLA-poly(ethylene glycol) (PEG) based precision-polyester (P2s) platform, permitting 5-12 periodically spaced carboxyl functional groups on the polymer backbone. These carboxyl groups were utilized to achieve variable degrees of gambogic acid (GA) conjugation to facilitate ligand-receptor stoichiometry optimization. These P2s-GA combined with fluorescent P2s upon emulsification form nanosystems (P2Ns) of size <150 nm with GA expressed on the surface. The P2Ns outclass conventional PLGA-GA nanosystems in cellular uptake using caco-2 intestinal model cultures. The P2Ns showed a proportional increase in cellular uptake with an increase in relative surface GA density from 0 to 75%; the slight decline for 100% GA density was indicative of receptor saturation. The intracellular trafficking of P2Ns in live caco-2 cells demonstrated the involvement of endocytic pathways in cellular uptake. The P2Ns manifest transferrin receptor (TfR) colocalization in ex vivo intestinal tissue sections, despite blocking of the receptor with transferrin (Tf) noncompetitively, i.e., independently of receptor occupation by native ligand. The in vivo application of P2Ns was demonstrated using cyclosporine (CsA) as a model peptide. The P2Ns exhibited modular release in vivo, as a function of surface GA density. This approach may contribute to the development of personalized dose regimen.

Impacts of Hydrological Alterations on Water Quality

This chapter presents an overview of the response of water quality to hydrological alterations due to anthropogenic activities and how this drives the need for environmental water provisions. The chapter outlines the major driving processes of water quality change and highlights how interactions between water quantity and quality depend on the characteristics of individual catchments and anthropogenic influences. It also discusses management strategies to mitigate some water quality problems using environmental water releases. Salinity, water temperature, nutrient concentrations, and dissolved oxygen have been selected as both representative and important indicators of stream water quality. The flow-dependent processes, anthropogenic impacts, and management options have been discussed for each of these.