Megumi Sugiyama

Real-time measurement of oxyhemoglobin concentration changes in the frontal micturition area: an fNIRS study

To explore brain activity in the frontal micturition area during natural bladder behavior.

Pathogenesis of reduced or increased bladder sensation

Pathogenesis of reduced or increased bladder sensation is not well known. Hence, we systematically investigated the frequency of reduced or increased bladder sensation in neurologic/mental diseases.

Weak detrusor contractility correlates with motor disorders in Parkinson's disease

Limited attention has been paid to the relationship between urinary symptoms or urodynamic findings and motor disorders in Parkinsons disease (PD). We aimed to correlate pressure‐flow urodynamic parameters with video‐gait analysis parameters in PD. We recruited 41 patients with PD (25 men and 16 women; age, 70.6 ± 8.5 years; H & Y motor grading: 2 [range, 1–3]; disease duration: 4 years [range, 1–7]; taking levodopa 300 mg/day [range, 100–400]). All patients underwent pressure‐flow urodynamics (parameters: first sensation, bladder capacity, detrusor overactivity [noted in 24 patients], and Watts factor [WF]) and video‐gait analysis (parameters: time and number of strides for 5‐m gait [simple task] and time for timed up and go [complex task]). Statistical analysis was made by Mann‐Whitneys U‐test for analyzing the relation between detrusor overactivity and gait as well as Spearmans rank‐correlation coefficient test for analyzing the relation between the remaining parameters and gait. We found no relation between filling‐phase urodynamics (detrusor overactivity, first sensation, and bladder capacity) and video‐gait analysis parameters. By contrast, we found a significant relation between voiding‐phase urodynamics (WF, reflecting detrusor power) and all three video‐gait analysis parameters (reflecting lower‐half bradykinesia and loss of postural reflex) in our PD patients (P < 0.01). The close relation between the WF and motor disorders in the present study suggests that, though clinically mild, a weak detrusor in PD might have a central origin. We should follow postvoid residual volume carefully in PD patients with advanced gait disorder, because postvoid residual volume might increase in such patients.

White Matter Lesions or Alzheimer's Disease:: Which Contributes More to Overactive Bladder and Incontinence in Elderly Adults with Dementia?

Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this paper. Author Contributions: Boureau: acquisition of participants, interpretation of data, preparation of manuscript. Bourbouloux: analysis of data. Retornaz: study concept and design. Berrut: study concept and design, interpretation of data. de Decker: study concept and design, preparation of manuscript. Sponsor’s Role: No sponsor.

Tolterodine activates the prefrontal cortex during bladder filling in OAB patients: A real-time NIRS-urodynamics study

Studies of overactive bladder (OAB) have shown urothelial/suburothelial changes and increased bladder afferents, while in the brain the frontal micturition area that normally suppresses the bladder is deactivated. It has been unclear whether anticholinergic medication could reverse this suppression. To address this question, we performed a real‐time NIRS (near‐infrared spectroscopy)‐urodynamic study in OAB patients before and after the administration of an anticholinergic agent, tolterodine.

Lower urinary tract function in dementia with Lewy bodies (DLB)

Dementia with Lewy bodies (DLB) is the second most common degenerative cause of dementia, whereas lower urinary tract (LUT) function in DLB patients has not been fully delineated. We investigated LUT function in DLB by clinical‐urodynamic observations.

Influence of Body Position on Defecation in Humans

Objectives: To compare three positions for defecation by measuring abdominal pressure and the anorectal angle simultaneously.

How the Bladder Senses? A Five‐Grade Measure

Objectives: During bladder filling, the bladder starts to sense it and the sensation steadily increases. However, little is known concerning volume‐sensory correlation in normal bladder and pressure‐sensory correlation during detrusor overactivity (DO). We aimed to real‐time assess bladder sensation in normal bladder and DO using a five‐grade measure.

Do Sacral/Peripheral Lesions Contribute to Detrusor-Sphincter Dyssynergia?

Objectives: While detrusor‐sphincter dyssynergia (DSD) occurs in conjunction with lesions between the brainstem and the sacral cord, it is not well known whether sacral/peripheral lesions contribute to DSD. We studied the relationship between DSD and sacral/peripheral lesions.

Lower Urinary Tract Function in Spinocerebellar Ataxia 6.

Objective: To investigate lower urinary tract function in spinocerebellar ataxia type 6 (SCA6).