Mehmet Akkurt

Anti-tubercular Activity of Ruthenium (II) Complexes with Polypyridines

A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2′-bipyridines; 2,2′-6′,2′-terpyridines, di-alkyloxy-2,2′-6,2-bipyridine-3,3′-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1–10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.

3,5-Bis(4-fluoro-phen-yl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde.

In the title molecule, C16H12F2N2O, the pyrazole ring adopts a slight envelope conformation with the methylene C atom deviating by 0.114 (3) Å from the mean plane of the other four atoms [maximum deviation = 0.021 (3) Å]. The dihedral angles between the four essentially planar atoms of the pyrazole ring and the fluoro-substituted benzene rings are 2.6 (2) and 82.2 (2)°. The dihedral angle between the two benzene rings is 83.7 (2)°. The crystal packing is stabilized by weak intermolecular C—H⋯O hydrogen bonds.

Reaktionen cyclischer Oxalylverbindungen, 34. Mitt.: Synthese von Dibenzoylacet-N-carboxyalkylamiden und semiempirische Rechnungen zur Keto-Enol Tautomerie

Summary4-Benzoyl-5-phenylfuran-2,3-dione (1) and the urethanes2 combine under loss of carbon monoxide yielding the open chain dibenzoylacetic acid derivatives3 and4. 3a, b only can be cyclized to the oxazinone5. The keto-enole tautomerism3 ⇌4 is further investigated with aid of semiempirical quantum chemical calculations, based upon the molecular geometry of3a, deduced from an X-ray study.

2,4-Bis(4-fluoro-phen-yl)-2,3-dihydro-1H-1,5-benzodiazepine.

In the title compound, C21H16F2N2, the seven-membered 1,4-diazepine ring of the benzodiazepine ring system adopts a distorted-boat conformation. The benzene ring of this system makes dihedral angles of 18.6 (2) and 78.8 (2)° with those of two fluorophenyl substituents. In the crystal, inversion dimers linked by two weak C—H⋯F hydrogen bonds generate R 2 2(20) ring motifs. There are also weak N—H⋯π and C—H⋯π interactions.

Bis(1,3-dibutylthiourea)dicyanido­mercury(II)

In the title compound, [Hg(CN)2(C9H20N2S)2], the Hg atom lies on a twofold rotation axis. There is only half a molecule in the asymmetric unit. The Hg atom has a distorted tetrahedral coordination involving the S atoms of two 1-butyl-3-propylthiourea groups and the C atoms of the two CN− anions. In the crystal packing, adjacent molecules are connected by intermolecular N—H⋯N and N—H⋯S hydrogen bonds, forming infinite chains in three dimensions.

Synthesis of 1-substituted benzimidazole metal complexes and structural characterization of dichlorobis(1-phenyl-1 H -benzimidazole- κN 3)cobalt(II) and dichlorobis (1-phenyl-1 H -benzimidazole- κN 3)zinc(II)

The Co(II), Zn(II), Ni(II), Cu(II), and Fe(II) complexes of 1-phenylbenzimidazole were synthesized and characterized by NMR and elemental analyses. The crystal structures of dichlorobis(1-phenyl-1 H-benzimidazole-κN3 )cobalt(II) and dichlorobis(1-phenyl-1 H-benzimidazole-κN3 )zinc(II) have been determined by single-crystal X-ray diffraction.

Zur Struktur des Diethylgermanium-diphenylsiliciumoxids und zur Konformation von achtringen mit Silicium und Germanium

Diethylgermanium-diphenylsilicon oxide [(Et2Ge)O(Ph2Si)O]2 has been prepared by reaction of diethylgermanium dichloride and diphenyldihydroxysilane. Spectra and X-ray analysis showed the presence of a puckered eight-membered silicon—germanium—oxygen ring. The ethyl groups of the germanium atoms are disordered. A procedure is proposed for eight-membered rings with low symmetry to obtain a classification into clearly explaining ring forms based on exact or approximated planes put through as many ring atoms as possible. All of the 42 published eight-membered rings with silicon or germanium and oxygen, nitrogen or carbon could be classified by this method.

1,3-Bis(4-fluoro-phen-yl)-N,N'-(propane-1,3-diyl-idene)dihydroxyl-amine.

The title compound, C15H12F2N2O2, crystallizes with two molecules (A and B) in the asymmetric unit. Both aromatic rings of both molecules are disordered over two orientations [occupancy ratios of 0.768 (3):0.232 (3) and 0.770 (3):0.230 (3) for molecule A and 0.789 (3):0.211 (3) and 0.789 (3):0.211 (3) for molecule B]. The dihedral angles between the planes of the major and minor components of the disordered aromatic rings are 72.0 (4) and 71.2 (4)° for molecule A, and 70.2 (4) and 71.5 (2)° for molecule B. In the crystal, both molecules form inversion dimers with R 2 2(6) ring motifs via pairs of intermolecular O—H⋯N hydrogen bonds. The dimers are linked, forming zigzag C(7) chains along the c axis. Weak C—H⋯π interactions help to consolidate the packing.

3,4-Dimeth­oxy-N-(3-nitro­benzyl­idene)aniline

In the title molecule, C15H14N2O4, the dihedral angle between the two benzene rings is 29.52 (8)°. The nitro and two methoxy substituents are almost coplanar with their respective benzene rings. The crystal structure is stabilized by intermolecular C—H⋯O interactions.

3‐(2‐Furyl)‐4‐(4‐methoxy­phenyl)‐1H‐1,2,4‐triazole‐5(4H)‐thione

The title compound, C13H11N3O2S, has a non-planar conformation. The dihedral angles are 3.41 (8) and 85.48 (7)° between the triazole ring plane and the furan and benzene ring planes, respectively. The crystal packing is stabilized by several hydrogen bonds.