Mehmet Erikoglu

Effects of Gender on the Severity of Sepsis

PurposeTo investigate the differences between male and female rats and the effects of sex hormones on tissue changes in the lung and liver in a sepsis model.MethodsSixty Sprague-Dawley rats were divided into six groups of ten. Groups 1 and 2 were the control male and female groups, respectively, subjected only to sepsis; groups 3 and 4 were the male and female groups, respectively, subjected to sepsis, then given 0.04 mg/kg estrogen + progesterone (E-P) intramuscularly (i.m.); and groups 5 and 6 were the male and female groups, respectively, subjected to sepsis, then given 0.5 mg/kg testosterone (T) i.m. The rats were killed and the histopathological changes in the lung and liver were examined, and plasma endotoxin levels were measured.ResultsHistopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the E-P groups than in the other groups. Moreover, signs of systemic endotoxemia in plasma were proportionally less in the female rats and in the E-P groups than in the male rats and the T groups.ConclusionFemale rats subjected to sepsis showed less liver and lung tissue damage and less systemic endotoxemia than male rats, because of the effects of female sex hormones.

Çok arterli böbrek nakilleri: Erken dönem sonuçlarımız

GIRIŞ Bobrek nakli, basarili cerrahi teknikler, ilerleyen immunsupresif tedavi yontemleri ve yogun bakim sartlarindaki gelismeler sayesinde son donem bobrek yetmezligi olan hastalarin tedavisinde en etkili yontem olmustur. Bu gelismeler sayesinde hastalarin hem yasam suresi hem de yasam kalitesi artmistir (1). Bobrek nakli icin kullanilan organlarda en sik rastlanan anomali renal arterin sayisal anomalileridir. Bir veya her iki bobrekte birden fazla sayida renal arter bulunmasi orani %20-35’dir. Renal ven anomalileri ise arter anomalilerinden daha az gorulmektedir. Damar anomalisi olan bobregin cikartilmasi ve nakil edilmesi normal bobrege gore daha zor olmasi nedeniyle soguk ve sicak iskemi sureleri uzayabilmekte ve bu durum gecikmis greft fonksiyonuna neden olmaktadir (2, 3).

Foliküler adenom ile papiller karsinom ilişkisi

GIRIŞ Tiroidin en sik gorulen selim tumoru folikuler adenomlardir. Adenomda histopatolojik olarak selim ve kapsullu bir dokunun buyumesi soz konusudur. Folikuler adenomlar iyi sinirli tek lezyon seklinde olup adenomu normal tiroid dokusundan ayiran kapsulleri vardir. Genellikle genc eriskinlerde gorulurler ve siklikla 3 cm’den daha kucuk soliter lezyonlardir. Mikroskopik olarak folikuler adenomlar kolloid, embriyonal, fetal ve Hurtle hucreli varyant olarak siniflandirilabilir (1).