Mehmet Koray Gök

Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine.

The aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly(acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)gc indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine.

Sodyum Akrilat Esaslı Hidrojel ve Kriyojellerin Şişme, Adsorpsiyon ve Mekanik Özelliklerinin İncelenmesi

Bu calismada, sodyum akrilat esasli hidrojel ve kriyojellerin sisme davranislari (sisme kapasitesi, denge sisme degeri ve sisme kinetigi), boyar madde (metilen mavisi) adsorpsiyonu ve mekanik ozellikleri karsilastirmali olarak incelenmistir. Kinetik paramatreler, dogrusal ve dogrusal olmayan metotlar kullanilarak belirlenmistir. Buna ek olarak, kriyojel ve hidrojel yapilarin yuzey morfolojileri, taramali elektron mikroskobu (SEM) kullanilarak karakterize edilmistir. Analizlerden elde edilen tum sonuclar karsilastirmali olarak degerlendirilmistir. In this study, swelling behavior (swelling capacity, equilibrium swelling ratio and swelling kinetics), basic dye (methylene blue) adsorption and mechanical properties of sodium acrylate based hydrogel and cryogels were comparatively investigated. Kinetic parameters were determined using linear and non-linear methods. In addition, the surface morphologies of cryogel and hydrogel structures were characterized using by Scanning Electron Microscopy (SEM). All results obtained from analyses were comparatively evaluated. Anahtar kelimeler: Hidrojel, Kriyojel, Adsorpsiyon, Sodyum akrilat, Dogrusal ve dogrusal olmayan analiz yontemleri.