Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Mehmet Salih Gurel is active.

Publication


Featured researches published by Mehmet Salih Gurel.


International Journal of Dermatology | 2002

Cutaneous leishmaniasis in Sanliurfa: epidemiologic and clinical features of the last four years (1997–2000)

Mehmet Salih Gurel; Mustafa Ulukanligil; Hatice Ozbilge

Background Sanliurfa is located in south‐east Anatolia, the region with the largest focus of anthroponotic cutaneous leishmaniasis (CL) in Turkey. The present study was designed to determine the epidemiological and clinical patterns of cases of CL in the Sanliurfa area over a period of 4 years (1997–2000).


Clinical and Experimental Dermatology | 2004

The psychological impact of cutaneous leishmaniasis.

Medaim Yanik; Mehmet Salih Gurel; Zeynep Simsek; Mahmut Katı

A psychiatric disorder would be associated with extensive, unsightly lesions on exposed body parts. Cutaneous leishmaniasis (CL) has long been endemic in Sanliurfa and is called ‘beauty scar’. The aim of this study was to determine psychological impact of CL. Patients with active CL, with CL that had healed with scaring, and healthy controls were included in this case–control study. The Hospital Anxiety Depression Scale (HAD), Body Image Satisfaction Scale (BIS), and Dermatology Quality of Life Scale (DQL) assessments were performed to determine the psychological effect of CL. The patients with CL had significantly higher HAD anxiety and depression subscale scores than the control groups. Patients with CL have decreased body satisfaction and lower quality of life than those in the control group. It was found that CL patients with active lesions have the lowest quality of life score than other groups. CL lesions on exposed body parts such as the face and hands, active CL for more than 1 year, permanent scar formation, and social stigmatization cause anxiety, depressive symptoms, decreased body satisfaction and quality of life in CL patients.


Memorias Do Instituto Oswaldo Cruz | 1998

Adenosine Deaminase Activities in Sera, Lymphocytes and Granulocytes in Patients with Cutaneous Leishmaniasis

Ozcan Erel; Mehmet Salih Gurel; Vedat Bulut; Adnan Seyrek; Yüksel Özdemir

Adenosine deaminase (ADA) activities in sera, lymphocytes and granulocytes in patients with cutaneous leishmaniasis were investigated and compared with control groups. Fifty patients and 50 healthy individuals were studied. The clinical diagnosis was parasitologically confirmed by culture and Giemsa stain. ADA activities were measured by colorimetric method. Serum ADA activities 37.80 +/- 11.90, 18.28 +/- 6.08 IU/L (p < 0.0001), lymphocyte specific ADA activities 14.90 +/- 7.42, 8.38 +/- 7.42 U/mg protein (p = 0.04), granulocyte specific ADA activities 1.15 +/- 0.73, 1.09 +/- 0.67 U/mg protein (p > 0.05) were found in patients and control groups, respectively. ADA activity increases in some infectious diseases were cell mediated immune mechanisms are dominant. In cutaneous leishmaniasis, lymphokine-mediated macrophage activity is the main effector mechanism. Increase in serum and lymphocyte ADA activities in patients with cutaneous leishmaniasis may be dependent on and reflects the increase in phagocytic activity of macrophages and maturation of T-lymphocytes.


International Journal of Dermatology | 2005

Quality of life instrument for Turkish people with skin diseases.

Mehmet Salih Gurel; Medaim Yanik; Zeynep Simsek; Mahmut Katı; Ahmet Karaman

Background and objective  To develop a new, short, self‐administrated subjective quality of life (QOL) instrument for Turkish people with skin diseases.


Memorias Do Instituto Oswaldo Cruz | 1999

Reactive Nitrogen and Oxygen Intermediates in Patients with Cutaneous Leishmaniasis

Ozcan Erel; Vedat Bulut; Mehmet Salih Gurel

The metabolisms of reactive nitrogen and oxygen intermediates (RNI and ROI) in patients with cutaneous leishmaniasis (CL) were investigated and compared with those of healthy subjects. To determine RNI metabolism, nitrite plus nitrate concentrations were measured spectrophotometrically. Nitrite concentration in plasma was determined directly by the Griess method. Nitrate levels in plasma were measured after reduction into nitrite by using copper-cadmium-zinc. ROI metabolism was evaluated by measuring erythrocyte superoxide dismutase, catalase and glutathione peroxidase activities. Plasma nitrite plus nitrate levels and erythrocyte superoxide dismutase activity were higher in the patient group than healthy subjects (p<0.01). In contrast, erythrocyte catalase and glutathione peroxidase activities were lower (p<0.05, p<0.01, respectively). ROI metabolism was altered in relation to hydrogen peroxide elevation in patients with CL. These alterations in ROI enable nitric oxide (NO) to amplify its leishmanicidal effect. The determination of ROI and RNI in patients with CL may be a useful tool to evaluate effector mechanisms of NO and clinical manifestations.


Infection and Immunity | 2002

Antimonial Therapy Induces Circulating Proinflammatory Cytokines in Patients with Cutaneous Leishmaniasis

Selahaddin Gur; Mehmet Salih Gurel; Vedat Bulut; Mustafa Ulukanligil

ABSTRACT The objective of this study was to evaluate the association between antimonial therapy and circulating levels of proinflammatory cytokines in patients with cutaneous leishmaniasis (CL). Patients were treated with conventional chemotherapy by using pentavalent antimonium salts (Glucantime) for 3 weeks. Circulating plasma levels of the proinflammatory cytokines interleukin-1β (IL-1β), IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) were determined for CL patients and healthy subjects before and 3 weeks after the treatment was started. Plasma IL-1β, IL-6, IL-8, and TNF-α levels were significantly higher for pretreatment CL patients than for healthy subjects. Proinflammatory cytokines significantly increased after 21 days postinfection compared to levels for the pretreatment patients. These increments were approximately 3-fold for IL-1β and TNF-α levels, 10-fold for IL-6 levels, and 20-fold for IL-8 levels in patients with CL. Taken together these results indicate that circulating proinflammatory cytokine levels were increased in patients with CL as a consequence of host defense strategies, and antimonial therapy may induce these cytokines by affecting the macrophage or other components of the host defense system.


Biological Trace Element Research | 1998

Alterations of serum selenium, zinc, copper, and iron concentrations and some related antioxidant enzyme activities in patients with cutaneous leishmaniasis

Ozcan Erel; Mehmet Salih Gurel; Senel Avci; Necmeddim Aktepe

The aim of this study was to measure the alterations in serum selenium (Se), copper (Cu), zinc (Zn), and iron (Fe) concentrations and their carrier proteins, ceruloplasmin (Cp), transferrin (Tf) albumin, and related antioxidant enzyme activities, erythrocyte Cu-Zn Superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in patients with cutaneous leishmaniasis (CL). Erythrocyte Cu-Zn SOD activities, serum Cu concentrations, and Cp levels were found to be significantly higher in the patients group than those of controls. However, GSH-Px and CAT activities and Se, Zn, Fe, and Tf levels were lower in patients than in the control subjects. There were positive important correlation’s between Cu-Zn SOD and Cp, Cu-Zn SOD and Cu, Cp and Cu, GSH-Px and Se, and Fe and CAT in the patients group. Our results showed that serum essential trace elements Se, Zn, Cu, and Fe concentrations and their related enzymes Cu-Zn SOD, GSH-Px, and CAT activities change in CL patients. The changes may be a part of defense strategies of organism and are induced by the hormonelike substances.


Biological Trace Element Research | 2002

Associations among plasma selenium, zinc, copper, and iron concentrations and immunoregulatory cytokine levels in patients with cutaneous leishmaniasis.

Selahattin Gur; Ozcan Erel; Mehmet Salih Gurel

Plasma essential trace elements, selenium, copper, zinc, and iron concentrations and the levels of immunoregulatory cytokines, interleukin-1β (IL-1β), interleukin-2 receptor (IL-2r), IL-6, IL-8, and tumor necrosis factor-α (TNF-α) were evaluated in patients with cutaneous leishmaniasis (CL) to investigate a possible role of these cytokines on selenium, zinc, copper, and iron homeostasis in CL patients. Plasma albumin levels were measured as an index of nutritional status. Plasma selenium, zinc, and iron concentrations, and IL-2r levels were significantly lower, and copper concentrations and IL-1β, IL-8, IL-6 and TNF-α levels were significantly higher in patients with CL than those of healthy controls. There was no significant difference in plasma albumin levels between two groups. There were positive important correlations between plasma selenium and IL-2r, copper and IL-6, and copper and IL-1β, and negative correlations between selenium and IL-8, iron and TNF-α, and zinc and IL-1β contents in patients with CL. Our results showed that plasma trace element contents change in patients with CL. These changes may not be a result of a specific deficiency from dietary inadequacies or imbalances, but, probably, a result of a part of the defense strategies of an organism that is regulated by immunoregulatory cytokines.


Clinical and Experimental Dermatology | 2005

Basal cell carcinoma in a leishmanial scar

Mehmet Salih Gurel; L. Inal; Ilyas Ozardali; S. A. Duzgun

A 50-year-old male farmer presented a minimally ulcerated and crusted central lesion 1 cm in diameter within a leishmanial scar on the left cheek (Fig. 1a). In his history, cutaneous leishmaniasis (CL) was prominent, which had spontaneously healed 40 years before, leaving a visible scar. There was no past history of any other skin cancers. He had outdoor occupation and wrinkled, actinic damaged facial skin. A 5-mm punch biopsy was taken from the lesion, and histological examination revealed a peripherally located focus of basal cell carcinoma (BCC) in a small area, and pseudoepitheliomatous hyperplasia in the remaining area. At that time, the patient refused further therapy. Two years later, the patient was re-admitted with the lesion enlarged on the leishmanial scar and having become a 3-cm noduloulcerating, firm tumour with an elevated pearly translucent border and centrally bleeding crust (Fig. 1b). The lesion was excised with a wide margin. Histopathological examination confirmed the diagnosis of BCC with a nest of basal neoplastic cells in the dermis. Surgical margins were tumour free. Severe solar changes were observed in the dermis adjacent to the tumour (Fig. 2). BCC is the commonest human cancer, and its incidence is increasing worldwide. Most BCCs occur on the head and neck, particularly on the upper central part of the face. In addition, some BCCs occur on the nonsun-exposed trunk and extremities. The causal relationship between UV exposure and BCC is not as clear as that between UV exposure and squamous cell carcinoma (SCC). Previous therapeutic radiation, chronic exposure to arsenic, and chronic ulcers predispose patients to the development of BCC, though this occurs much less commonly in this setting than does SCC. In addition, an association between BCC and scar tissue has been noted in several reports. The most common scar types associated with BCC are previous vaccination and small pox scars, while burn and surgical scars are associated with fewer cases. The question of how scars undergo malignant transformation is much debated, and the answer remains elusive. The long latent period between the time of injury and the development of carcinoma often makes it difficult to prove any direct relationship. The poor vascularity and elasticity of scar tissue may render the overlying epithelium more susceptible to injury and carcinogens. It is unlikely that trauma alone induces carcinogenesis. In the case presented here, a BCC developed in a 50year-old man at the site of a leishmanial scar 40 years after healing. Histological examination of the tumour revealed severe actinic damage to the tissues adjacent to the neoplasm, attesting to the role played by both factors in the induction of this tumour. This finding, coupled with the history of an atrophic scar, most probably accounts for the development of the BCC in this patient. Effective host– parasite interaction in CL results in local tissue destruction, ulceration and scar formation. The association of CL with the subsequent development of malignancy at the site of the previous lesion is rarely reported. There have been a few cases involving CL and malignancy, such as a 17-year-old boy with CL and BCC and a 53-year-old man with BCC arising in a leishmanial scar. We concluded that CL is not a premalignant lesion, as there have been very few cases of BCC and no case of SCC reported. Histologic examination in our case showed actinic damage in the surrounding uninvolved areas of the dermis. Thus, the development of a subsequent malignant neoplasm should be considered a rare but possible sequela of CL due to atrophic scar and chronic solar trauma.


Skin Research and Technology | 2014

Reflectance confocal microscopy vs. standardized skin surface biopsy for measuring the density of Demodex mites

A. V. Turgut Erdemir; Mehmet Salih Gurel; A. E. Koku Aksu; F. Bilgin Karahalli; P. Incel; N. S. Kutlu Haytoğlu; Tuğba Falay

Reflectance confocal microscopy (RCM) has been recently shown to be effective for measuring the Demodex mite density.

Collaboration


Dive into the Mehmet Salih Gurel's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar

Aslı Vefa Erdemir

Istanbul Medeniyet University

View shared research outputs
Top Co-Authors

Avatar

Ozcan Erel

Yıldırım Beyazıt University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge