Mehran Moazen

Assessment of the role of sutures in a lizard skull: a computer modelling study

Sutures form an integral part of the functioning skull, but their role has long been debated among vertebrate morphologists and palaeontologists. Furthermore, the relationship between typical skull sutures, and those involved in cranial kinesis, is poorly understood. In a series of computational modelling studies, complex loading conditions obtained through multibody dynamics analysis were imposed on a finite element model of the skull of Uromastyx hardwickii, an akinetic herbivorous lizard. A finite element analysis (FEA) of a skull with no sutures revealed higher patterns of strain in regions where cranial sutures are located in the skull. From these findings, FEAs were performed on skulls with sutures (individual and groups of sutures) to investigate their role and function more thoroughly. Our results showed that individual sutures relieved strain locally, but only at the expense of elevated strain in other regions of the skull. These findings provide an insight into the behaviour of sutures and show how they are adapted to work together to distribute strain around the skull. Premature fusion of one suture could therefore lead to increased abnormal loading on other regions of the skull causing irregular bone growth and deformities. This detailed investigation also revealed that the frontal–parietal suture of the Uromastyx skull played a substantial role in relieving strain compared with the other sutures. This raises questions about the original role of mesokinesis in squamate evolution.

Predicting skull loading: applying multibody dynamics analysis to a macaque skull.

Evaluating stress and strain fields in anatomical structures is a way to test hypotheses that relate specific features of facial and skeletal morphology to mechanical loading. Engineering techniques such as finite element analysis are now commonly used to calculate stress and strain fields, but if we are to fully accept these methods we must be confident that the applied loading regimens are reasonable. Multibody dynamics analysis (MDA) is a relatively new three dimensional computer modeling technique that can be used to apply varying muscle forces to predict joint and bite forces during static and dynamic motions. The method ensures that equilibrium of the structure is maintained at all times, even for complex statically indeterminate problems, eliminating nonphysiological constraint conditions often seen with other approaches. This study describes the novel use of MDA to investigate the influence of different muscle representations on a macaque skull model (Macaca fascicularis), where muscle groups were represented by either a single, multiple, or wrapped muscle fibers. The impact of varying muscle representation on stress fields was assessed through additional finite element simulations. The MDA models highlighted that muscle forces varied with gape and that forces within individual muscle groups also varied; for example, the anterior strands of the superficial masseter were loaded to a greater extent than the posterior strands. The direction of the muscle force was altered when temporalis muscle wrapping was modeled, and was coupled with compressive contact forces applied to the frontal, parietal and temporal bones of the cranium during biting. Anat Rec, 291:491–501, 2008.

Combined finite element and multibody dynamics analysis of biting in a Uromastyx hardwickii lizard skull

Lizard skulls vary greatly in shape and construction, and radical changes in skull form during evolution have made this an intriguing subject of research. The mechanics of feeding have surely been affected by this change in skull form, but whether this is the driving force behind the change is the underlying question that we are aiming to address in a programme of research. Here we have implemented a combined finite element analysis (FEA) and multibody dynamics analysis (MDA) to assess skull biomechanics during biting. A skull of Uromastyx hardwickii was assessed in the present study, where loading data (such as muscle force, bite force and joint reaction) for a biting cycle were obtained from an MDA and applied to load a finite element model. Fifty load steps corresponding to bilateral biting towards the front, middle and back of the dentition were implemented. Our results show the importance of performing MDA as a preliminary step to FEA, and provide an insight into the variation of stress during biting. Our findings show that higher stress occurs in regions where cranial sutures are located in functioning skulls, and as such support the hypothesis that sutures may play a pivotal role in relieving stress and producing a more uniform pattern of stress distribution across the skull. Additionally, we demonstrate how varying bite point affects stress distributions and relate stress distributions to the evolution of metakinesis in the amniote skull.

Periprosthetic fracture fixation of the femur following total hip arthroplasty: a review of biomechanical testing.

BACKGROUND periprosthetic femoral fracture can occur following total hip arthroplasty. Fixation of these fractures are challenging due to the combination of fractured bone with an existing prosthesis. There are several clinical studies reporting the failure of fixation methods used for these fractures, highlighting the importance of further biomechanical studies in this area. METHODS the current literature on biomechanical models of periprosthetic femoral fracture fixation is reviewed. The methodologies involved in the experimental and computational studies of this fixation are described and compared. FINDINGS areas which require further investigation are highlighted and the potential use of finite element analysis as a computational tool to test the current fixation methods is addressed. INTERPRETATION biomechanical models have huge potential to assess the effectiveness of different fixation methods. Experimental in vitro models have been used to mimic periprosthetic femoral fracture fixation however, the numbers of measurements that are possible in these studies are relatively limited due to the cost and data acquisition constraints. Computer modelling and in particular finite element analysis is a complimentary method that could be used to examine existing protocols for the treatment of periprosthetic femoral fracture and, potentially, find optimum fixation methods for specific fracture types.

Biomechanical assessment of evolutionary changes in the lepidosaurian skull

The lepidosaurian skull has long been of interest to functional morphologists and evolutionary biologists. Patterns of bone loss and gain, particularly in relation to bars and fenestrae, have led to a variety of hypotheses concerning skull use and kinesis. Of these, one of the most enduring relates to the absence of the lower temporal bar in squamates and the acquisition of streptostyly. We performed a series of computer modeling studies on the skull of Uromastyx hardwickii, an akinetic herbivorous lizard. Multibody dynamic analysis (MDA) was conducted to predict the forces acting on the skull, and the results were transferred to a finite element analysis (FEA) to estimate the pattern of stress distribution. In the FEA, we applied the MDA result to a series of models based on the Uromastyx skull to represent different skull configurations within past and present members of the Lepidosauria. In this comparative study, we found that streptostyly can reduce the joint forces acting on the skull, but loss of the bony attachment between the quadrate and pterygoid decreases skull robusticity. Development of a lower temporal bar apparently provided additional support for an immobile quadrate that could become highly stressed during forceful biting.

Rigid-body analysis of a lizard skull: Modelling the skull of Uromastyx hardwickii

Lizard skulls vary greatly in their detailed morphology. Theoretical models and practical studies have posited a definite relationship between skull morphology and bite performance, but this can be difficult to demonstrate in vivo. Computer modelling provides an alternative approach, as long as hard and soft tissue components can be integrated and the model can be validated. An anatomically accurate three-dimensional computer model of an Uromastyx hardwickii skull was developed for rigid-body dynamic analysis. The Uromastyx jaw was first opened under motion control, and then muscle forces were applied to produce biting simulations where bite forces and joint forces were calculated. Bite forces comparable to those reported in the literature were predicted, and detailed muscular force information was produced along with additional information on the stabilizing role of temporal ligaments in late jaw closing.

Periprosthetic Femoral Fracture — A Biomechanical Comparison Between Vancouver Type B1 and B2 Fixation Methods

Current clinical data suggest a higher failure rate for internal fixation in Vancouver type B1 periprosthetic femoral fracture (PFF) fixations compared to long stem revision in B2 fractures. The aim of this study was to compare the biomechanical performance of several fixations in the aforementioned fractures. Finite element models of B1 and B2 fixations, previously corroborated against in vitro experimental models, were compared. The results indicated that in treatment of B1 fractures, a single locking plate can be without complications provided partial weight bearing is followed. In case of B2 fractures, long stem revision and bypassing the fracture gap by two femoral diameters are recommended. Considering the risk of single plate failure, long stem revision could be considered in all comminuted B1 and B2 fractures.

The Effect of Fracture Stability on the Performance of Locking Plate Fixation in Periprosthetic Femoral Fractures

Periprosthetic femoral fracture (PFF) fixation failures are still occurring. The effect of fracture stability and loading on PFF fixation has not been investigated and this is crucial for optimum management of PFF. Models of stable and unstable PPFs were developed and used to quantify the effect of fracture stability and loading in a single locking plate fixation. Stress on the plate was higher in the unstable compared to the stable fixation. In the case of unstable fractures, it is possible for a single locking plate fixation to provide the required mechanical environment for callus formation without significant risk of plate fracture, provided partial weight bearing is followed. In cases where partial weight bearing is unlikely, additional biological fixation could be considered.

From normal to fast walking: Impact of cadence and stride length on lower extremity joint moments

This study aimed to clarify the influence of various speeding strategies (i.e. adjustments of cadence and stride length) on external joint moments. This study investigated the gait of 52 healthy subjects who performed self-selected normal and fast speed walking trials in a motion analysis laboratory. Subjects were classified into three separate groups based on how they increased their speed from normal to fast walking: (i) subjects who increased their cadence, (ii) subjects who increased their stride length and (iii) subjects who simultaneously increased both stride length and cadence. Joint moments were calculated using inverse dynamics and then compared between normal and fast speed trials within and between three groups using spatial parameter mapping. Individuals who increased cadence, but not stride length, to walk faster did not experience a significant increase in the lower limb joint moments. Conversely, subjects who increased their stride length or both stride length and cadence, experienced a significant increase in all joint moments. Additionally, our findings revealed that increasing the stride length had a higher impact on joint moments in the sagittal plane than those in the frontal plane. However, both sagittal and frontal plane moments were still more responsive to the gait speed change than transverse plane moments. This study suggests that the role of speed in altering the joint moment patterns depends on the individuals speed-regulating strategy, i.e. an increase in cadence or stride length. Since the confounding effect of walking speed is a major consideration in human gait research, future studies may investigate whether stride length is the confounding variable of interest.

Evaluation of a new approach for modelling the screw-bone interface in a locking plate fixation: A corroboration study

Computational modelling of the screw–bone interface in fracture fixation constructs is challenging. While incorporating screw threads would be a more realistic representation of the physics, this approach can be computationally expensive. Several studies have instead suppressed the threads and modelled the screw shaft with fixed conditions assumed at the screw–bone interface. This study assessed the sensitivity of the computational results to modelling approaches at the screw–bone interface. A new approach for modelling this interface was proposed, and it was tested on two locking screw designs in a diaphyseal bridge plating configuration. Computational models of locked plating and far cortical locking constructs were generated and compared to in vitro models described in prior literature to corroborate the outcomes. The new approach led to closer agreement between the computational and the experimental stiffness data, while the fixed approach led to overestimation of the stiffness predictions. Using the new approach, the pattern of load distribution and the magnitude of the axial forces, experienced by each screw, were compared between the locked plating and far cortical locking constructs. The computational models suggested that under more severe loading conditions, far cortical locking screws might be under higher risk of screw pull-out than the locking screws. The proposed approach for modelling the screw–bone interface can be applied to any fixation involved application of screws.