Mehul Dalal
Takeda Pharmaceutical Company
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Publication
Featured researches published by Mehul Dalal.
Cancer | 2013
Alok A. Khorana; Mehul Dalal; Jay Lin; Gregory C. Connolly
Recent studies suggest that thromboprophylaxis is beneficial in preventing venous thromboembolism (VTE) in cancer outpatients, but this is not widely adopted because of incomplete understanding of the contemporary incidence of VTE and concerns about bleeding. Therefore, the authors examined the incidence and predictors of VTE in ambulatory patients with bladder, colorectal, lung, ovary, pancreas, or gastric cancers.
ClinicoEconomics and Outcomes Research | 2013
Alok A. Khorana; Mehul Dalal; Jay Lin; Gregory C. Connolly
Background This study examines venous thromboembolism (VTE)-associated resource utilization and real-world costs in ambulatory patients initiating chemotherapy for selected common high-risk solid tumors. Methods Health care claims data (2004–2009) from the IMS/PharMetrics® Patient-Centric database were collected for propensity score-matched adult cancer (lung, colorectal, pancreatic, gastric, bladder, or ovarian) patients initiating chemotherapy with VTE (n = 912) and without VTE (n = 2736). Health care resource utilization (inpatient, outpatient, and outpatient prescription drug claims) and costs were compared between the two cohorts during the 12-month follow-up period after the index VTE event. Incremental costs were adjusted for demographic and clinical covariates. Results Cancer patients with VTE had approximately three times as many all-cause hospitalizations (mean 1.38 versus 0.55 per patient) and days in hospital (10.19 versus 3.37), and more outpatient claims (331 versus 206) than cancer patients without VTE (all P < 0.0001). Cancer patients with VTE incurred higher overall all-cause inpatient costs (mean USD 21,299 versus USD 7459 per patient), outpatient costs (USD 53,660 versus USD 34,232 per patient), and total health care costs (USD 74,959 versus USD 41,691 per patient) than cancer patients without VTE (all P < 0.0001). Total mean VTE-related health care costs were USD 9247 per patient over 12 months. Adjusted mean incremental all-cause health care costs of VTE were USD 30,538 per patient for cancer overall, ranging from USD 11,946 for gastric to USD 38,983 for pancreatic cancer. Conclusion: VTE is associated with significant inpatient and outpatient resource utilization, and increased all-cause (in addition to VTE-related) health care costs among ambulatory cancer patients. Measures to prevent outpatient cancer-associated VTE may reduce health care utilization and costs in this population.
Endocrine Practice | 2015
Mehul Dalal; L. Xie; O. Baser; Andres DiGenio
OBJECTIVE To evaluate real-world outcomes in patients with type 2 diabetes mellitus (T2DM) receiving basal insulin who initiate add-on therapy with a rapid-acting insulin (RAI) or a glucagon-like peptide 1 (GLP-1) receptor agonist. METHODS Data were extracted retrospectively from a U. S. health claims database. Adults with T2DM on basal insulin who added an RAI (basal + RAI) or GLP-1 receptor agonist (basal + GLP-1) were included. Propensity score matching (with a 1 up to 3 ratio) was used to control for differences in baseline demographics, clinical characteristics, and health resource utilization. Endpoints included prevalence of hypoglycemia, pancreatic events, all-cause and diabetes-related resource utilization, and costs at 1-year follow-up. RESULTS Overall, 6,718 matched patients were included: 5,013 basal + RAI and 1,705 basal + GLP1. Patients in both groups experienced a similar proportion of any hypoglycemic event (P = .4079). Hypoglycemic events leading to hospitalization were higher in the basal + RAI cohort (2.7% vs. 1.8%; P = .0444). The basal + GLP-1 cohort experienced fewer all-cause (13.55% vs. 18.61%; P<.0001) and diabetes-related hospitalizations (11.79% vs. 15.68%; P<.0001). The basal + GLP-1 cohort had lower total all-cause health care costs (
The Diabetes Educator | 2013
Sean D. Sullivan; Mehul Dalal; James P. Burke
18,413 vs.
Value in Health | 2015
Kathy L. Schulman; Lois Lamerato; Mehul Dalal; Jennifer Sung; Mehul Jhaveri; Andrew Koren; U. Mallya; Jo Anne M Foody
20,821; P = .0002) but similar diabetes-related costs (
Postgraduate Medicine | 2015
Barbara J. Zarowitz; Carrie Allen; Terrence O’Shea; Mehul Dalal; Mark Haumschild; Andres DiGenio
9,134 vs.
Postgraduate Medicine | 2016
Gerry Oster; Sean D. Sullivan; Mehul Dalal; Mahmood R. Kazemi; Maria Rojeski; Carol H. Wysham; Jennifer Sung; Bryan Johnstone; Anna M.G. Cali; L.J. Wei; Louise Traylor; Henry Anhalt; Michelle Hull; John Van Vleet; Luigi Meneghini
8,985; P<.0001) compared with the basal + RAI cohort. CONCLUSIONS Add-on therapy with a GLP-1 receptor agonist in T2DM patients receiving basal insulin was associated with fewer hospitalizations and lower total all-cause costs compared with add-on therapy using an RAI and could be considered as an alternative to an RAI in certain patients with T2DM who do not achieve effective glycemic control with basal insulin.
Leukemia & Lymphoma | 2018
Erin Zagadailov; Shelby Corman; V.V. Chirikov; C Johnson; Cynthia Macahilig; Brian Seal; Mehul Dalal; Paul J Bröckelmann; Tim Illidge
Purpose The purpose of this study is to examine outcomes in adult patients with type 2 diabetes mellitus who received diabetes counseling and education (C/E) services compared with those who did not. Methods A matched, retrospective cohort study of 17 483 C/E recipients and 17 470 non-C/E controls was followed for up to 12 months. Outcomes included glycemic control (glycosylated hemoglobin A1C levels <7.0%), hypoglycemic events, and health care utilization and costs. Results Compared with the non-C/E group, patients in the C/E group had significantly lower A1C (7.7% vs 7.2%) and were more likely to achieve glycemic control at 6 months’ follow-up; they were also more likely to have a hypoglycemic event. During the 1-year period following the index date, C/E recipients had more inpatient visits (0.21 vs 0.20 visits per patient) and ambulatory visits (21.5 vs 18.6 visits per patient) compared with non-C/E controls. The increased use of health care services in the C/E groups was associated with
Postgraduate Medicine | 2014
Andres DiGenio; Sudeep Karve; Sean D. Candrilli; Mehul Dalal
2388 higher annual overall costs and
Postgraduate Medicine | 2013
John E. Anderson; Andrew S Rhinehart; Timothy Reid; Robert Cuddihy; Aleksandra Vlajnic; Mehul Dalal; E. Gemmen; Bryan Johnstone; Babak Abbaszadeh; Josh Reed; Jennifer Sheller; John Stewart; Essy Mozaffari
827 higher diabetes-related costs. Conclusions Diabetes C/E is associated with improved glycemic control, albeit with a slight increase in the risk of hypoglycemia. C/E was associated with higher health care costs across 12 months. Further analyses are needed to evaluate long-term cost-effectiveness of diabetes counseling and education.