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Featured researches published by Meiju Niu.


Inorganic Chemistry | 2013

Family of Mixed 3d–4f Dimeric 14-Metallacrown-5 Compounds: Syntheses, Structures, and Magnetic Properties

Fan Cao; Suna Wang; Dacheng Li; Su-Yuan Zeng; Meiju Niu; You Song; Jianmin Dou

An isomorphous family of mixed 3d-4f dodenuclear aggregates, {[Mn(III)8Ln4(Clshi)8(OAc)6(μ3-OCH3)2(μ3-O)2(CH3OH)12(H2O)2]·4CH3OH·xH2O)} (where Ln = Eu(III) (1), Gd(III) (2), Tb(III) (3), and Dy(III) (4); ClshiH3 = 5-chlorosalicylhydroxamic acid; x = 5 for 1 and 3; x = 6 for 2; x = 2 for 4), were synthesized and characterized. They were obtained from the reaction of ClshiH3 with Mn(OAc)2·4H2O and Ln(NO3)3·6H2O. These isomorphous mixed 3d-4f compounds represent a family of novel structures with lanthanide ions in the metallacrown (MC) ring. Each dodecanuclear aggregate contains two offset stacked 14-MC-5 units with M-N-O-M-N-O-Ln-O-N-M-O-N-M connectivity to capture one Ln(III) ion in the core of each MC. Two 14-MC-5 units are connected through O ions with four Mn ions and six O atoms arranged in a double Mn4O6 cubane. Magnetic measurement indicates that antiferromagnetic interactions are present between the metal ions. The Dy(III) analogue with high anisotropy and large spin shows slow magnetization relaxation at a direct-current field of 2 kOe.


CrystEngComm | 2013

Positional isomeric and substituent effect on the assemblies of a series of d10 coordination polymers based upon unsymmetric tricarboxylate acids and nitrogen-containing ligands

Ting Liu; Suna Wang; Jing Lu; Jianmin Dou; Meiju Niu; Dacheng Li; Junfeng Bai

Seven novel compounds, {[Zn2(L1)2]·2H2N(CH3)2·DMF}n (1), {[Cd2(L1)2]·2H2N(CH3)2·DMF}n (2), [Zn(HL2)(bpe)]n (3), [Zn2(HL2)2(bpea)2(H2O)]n (4), {[Cd2(HL2)2(bpe)(H2O)2]·2H2O}n (5), {[Cd2(HL2)2(bpea)(H2O)2]·2H2O}n (6) and {[Zn(HL3)(bpea)]·2H2O}n (7), were constructed based on three unsymmetrical tricarboxylate ligands and nitrogen-containing ligands (H3L1 = biphenyl-3,4′,5-tricarboxylic acid, H3L2 = biphenyl-3,3′,5-tricarboxylic acid, H3L3 = biphenyl-3-nitro-5,3′,5′-tricarboxylic acid, bpe = 1,2-bi(4-pyridyl)ethylene, bpea = 1,2-bi(4-pyridyl)ethane) under hydrothermal conditions. The positional isomeric and substituent effects of these ligands lead to fascinating structures. Compounds 1 and 2 afford 3D (3,6)-connected (4.62)2(42.610.83) rutile topologies based on dinuclear M2(CO2)2 SBUs. Compounds 3 and 4 are 4-connected diamondoid nets, which exhibit unusual roto-translational [2 + 2]-fold and common 4-fold interpenetration due to the different weak interactions among each interpenetrating motif, respectively. Compounds 5 and 6 are isostructural, both presenting 2D unique undulated (3,4)-connected (42.6)(42.63.8) topologies. Compound 7 possesses a 2D → 3D parallel polycatenation framework composed of (4,4) undulated sheets. The effects of the positions of the carboxylate groups and the substituent groups on the aromatic rings, the flexibility of the N-containing coligands as well as the coordination geometry of the metal centers are discussed in details. The fluorescence properties and thermal stability of the ligands and compounds have also been performed.


New Journal of Chemistry | 2016

Anti-proliferative activity and DNA/BSA interactions of five mono- or di-organotin(IV) compounds derived from 2-hydroxy-N′-[(2-hydroxy-3-methoxyphenyl)methylidene]-benzohydrazone

Min Hong; Guoliang Chang; Rui Li; Meiju Niu

Five new mono- or di-organotin(IV) complexes, Me2SnL (1), Ph2SnL (2), n-Bu2SnL (3), n-Oct2SnL (4) and n-BuSnCl(H2O)L·CH3CH2OH (5), where H2L is 2-hydroxy-N′-[(2-hydroxy-3-methoxyphenyl)methylidene]-benzohydrazone, were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H, 13C, 119Sn NMR). The crystal structures of all compounds were established by X-ray diffraction, showing the hydrazone Schiff base ligand bound to the tin atom as ONO tridentate chelate. In vitro cytotoxicity determination reveals that all compounds exhibit good activity toward three cisplatin-resistant human cancer cell lines: A549cisR, HeLacisR and MCF-7cisR cell lines. The possible structure–activity relationship of these compounds was studied from the effect of both alkyl groups bound with tin centers and the structure of organotin compounds on their in vitro antiproliferative activities. All complexes can interact with calf thymus DNA (CT-DNA) in the intercalation mode, as evidenced by UV-Vis absorption, luminescence and circular dichroism (CD) titrations. Furthermore, the interaction of all compounds and bovine serum albumin (BSA) in static mode was characterized by fluorescence spectroscopy methods, which were confirmed by the docking study. In addition, further studies reveal that the most active di-n-butyltin(IV) compound, inducing production of ROS, can potentially be used as anticancer drug.


RSC Advances | 2015

DNA/protein interaction, cytotoxic activity and magnetic properties of amino-alcohol Schiff base derived Cu(II)/Ni(II) metal complexes: influence of the nuclearity and metal ions

Meiju Niu; Zhen Li; Huanhuan Li; Xiao Li; Jianmin Dou; Suna Wang

Four coordination complexes based on two amino-alcohol derived Schiff base ligands, namely, [Cu(H2L1)(Cl)]·CH3OH (1), [Cu4(HL2)2(H2L2)2(H2O)(C2H5OH)]·2(ClO4)·2(C2H5OH) (2), [Ni2(H2L1)2(OAc)2(C2H5OH)2]2 (3) and [Ni4(HL2)3(μ3-O)(H2O)3]·9H2O (4) (H3L1 = {2-ethyl-2-((2-hydroxybenzylideneamino)propane-1,3-diol), and H3L2 = 2-ethyl-2-((2-hydroxy-3-methoxybenzylideneamino)propane-1,3-diol)}), were synthesized and characterized. Alkoxo and phenoxo groups of the Schiff base ligands bridge the metal atoms in diverse modes, leading to interesting mononuclear (1), dinuclear (3), and tetranuclear (2 and 4) complexes, respectively. The in vitro cytotoxic effect of these complexes on cancerous cell lines, including the human lung carcinoma cell line (A549), human colon carcinoma cell lines (HCT-116), human promyelocytic leukemia cells (HL-60) and the chronic myelogenous leukemia cell line (K-562) showed that all these complexes exhibited substantial cytotoxic activity. Their interactions with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were also investigated using UV-visible, fluorescence and synchronous fluorescence spectroscopic methods. All complexes could quench the intrinsic fluorescence of BSA in a static quenching process. Variable temperature magnetic properties of these complexes were investigated in details. The nuclearity and metal centers play an important role in the properties of the complexes.


Journal of Coordination Chemistry | 2014

Di-, tri-, and tetranuclear cobalt, copper, and manganese complexes bridged by μ-hydroxyl groups of tetradentate Schiff base ligands: structures, magnetic properties, and antitumor activities

Meiju Niu; Da-Wei Sun; Huanhuan Li; Zhiqiang Cao; Suna Wang; Jianmin Dou

[Co2(HL1)2(H2O)2](NO3) (1), [Cu2(H2L1)(HL1) (CH3COO)]·H2O (2), [Cu4(HL1)4(C2H5OH)]·C2H5OH·H2O (3), and [Mn3(HL2)2(CH3OH)2(CH3COO)4]·2(CH3OH)·H2O (4) {H3L1 = 2-ethyl-2-(2-hydroxybenzylideneamino)propane-1,3-diol, H3L2 = 2-ethyl-2-[(2-hydroxynaphthalene-1-yl)methyleneamino]propane-1,3-diol} have been synthesized and characterized by IR spectra, elemental analyses, single-crystal X-ray diffraction, TGA, XRD, and magnetic measurements. Compound 1 possesses mixed-valence dinuclear {Co2(μ2-O)2} with Co(II) and Co(III) ions linked through μ2-hydroxyl of Schiff base ligands. Compound 2 displays a binuclear structure with {Cu2(μ2-O)(η2-COO)} containing one μ2-hydroxyl and a single syn–syn acetate bridge. Compound 3 is tetranuclear with a cube-shaped {Cu4(μ3-O)4} core constructed by four Cu(II) centers and four μ3-hydroxyls of Schiff base ligands. Compound 4 displays a linear trinuclear {Mn3(μ2-O)2(η2-COO)2} structure in which the terminal Mn(III) and the central Mn(II) ions are linked by a μ2-hydroxyl of Schiff base and two syn–syn acetate bridges. The results show that terminal hydroxyl groups of Schiff base ligands play an important role in assembling polynuclear compounds. Magnetic properties and antitumor activities of these compounds were investigated. The antitumor activities reveal that 1 and 2 are more effective antitumor agents for K-562 and HL-60, respectively.


RSC Advances | 2015

Efficient biodiesel production from waste cooking oil using p-toluenesulfonic acid doped polyaniline as a catalyst

Meiju Niu; Xiangjin Kong

p-Toluenesulfonic acid doped polyaniline was developed as a catalyst for the production of biodiesel from waste cooking oil. The physical and chemical properties of the obtained catalyst were characterized in detail. It was found that the yield of fatty acid methylesters reached 97.1%, and the physical properties of the obtained biodiesel sample satisfied the requirement of ASTM D6751 standards. In addition, the catalyst exhibited excellent stability for 10 runs. Therefore, this heterogeneous catalyst has potential for biodiesel production from waste cooking oil, so further pilot tests deserve to be carried out and may be used in large-scale industries.


Journal of Photochemistry and Photobiology B-biology | 2015

A comparative study of cytotoxicity and interaction with DNA/protein of five transition metal complexes with Schiff base ligands

Meiju Niu; Min Hong; Guoliang Chang; Xiao Li; Zhen Li

Five transition metal complexes NiL(1)2 (1), CuL(1)2 (2), ZnL(1)2 (3), [MnL(1)2(N3)]n·nCH2Cl2 (4), CuL(2)2 (5) {HL(1)=3-{[2-(2-hydroxy-ethoxy)-ethylimino]-methyl}-naphthalen-2-ol, HL(2)=2-{[2-(2-hydroxy-ethoxy)-ethylimino]-methyl}-phenol} have been synthesized and fully characterized. In all of the complexes, the ligands coordinated to the metal ion in a negative fashion via O and N donor atoms. The X-ray structures of nickel complex 1 and copper complexes 2 and 5 are four-coordinated monomers and show slightly distorted square-planar geometry in the vicinity of the central metal atom. Zinc complex 3 exhibits a four-coordinated tetrahedral structure. Differently, manganese complex 4 reveals a six-coordinated octahedral structure, one-dimensional chain is linked by azide in the end-to-end mode. In vitro cytotoxicity of these complexes to various tumor cell lines was assayed by the MTT method. The results showed that most of these metal-Schiff base complexes exhibited enhanced cytotoxicity than Schiff base ligands, which clearly implied a positive synergistic effect. Moreover, these complexes appeared to be selectively active against certain cell lines. The interactions of these metal complexes with CT-DNA were investigated by UV-vis, fluorescence and CD spectroscopy, the results indicated that these complexes are metallointercalators and can interact with CT-DNA. The study of interaction between complexes and BSA indicated that all of the complexes could quench the intrinsic fluorescence of BSA in a static quenching process.


Journal of Photochemistry and Photobiology B-biology | 2016

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Zhen Li; Hui Yan; Guoliang Chang; Min Hong; Jianmin Dou; Meiju Niu

A series of novel copper (II) and nickel (II) complexes derived from chiral Schiff-base ligands [(R)/(S)-H2L(1)=(R)/(S)-2-[(1-Hydroxymethyl-propylimino)-methyl]-5-methoxy-phenol and (R)/(S)-H2L(2)=(R)/(S)-2-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-5-methoxy-phenol], were synthesized and characterized by elemental analyses, (1)H NMR spectra, FT-IR spectrum. The crystal structures of complexes 1-5 were determined through single crystal X-ray diffraction (SXRD). The structures showed the ligands coordinated to the Cu/Ni (II) ion in a neutral manner via ONO donor atoms, and oxygen atoms of solvent molecules occupy the axial positions in Ni (II) complexes 3 and 4. The complexes interactions with BSA and CT-DNA were investigated by various spectroscopic methods (UV-Visible, circular dichroism spectrum, fluorescence spectroscopic and synchronous fluorescence spectra). Interactions of chiral copper (II) complexes are stronger than nickel (II) complexes. Further, the cytotoxicities of the complexes 1-6 towards three kinds of cancerous cell lines, were human lung adenocarcinoma (A549), human cervical carcinoma cell (HeLa) and human breast cancer cell (MCF-7) respectively, were evaluated by MTT assay. All complexes exhibited good cytotoxic activity. Furthermore, Cu (II) complex 5 derived from (R)-Schiff-base ligand was found to be more effective towards HeLa cancerous cell. The results showed that chirality and metal ion have important influence on their anticancer activities and interactions with DNA/BSA.


PLOS ONE | 2015

Crystal Structure, Cytotoxicity and Interaction with DNA of Zinc (II) Complexes with o-Vanillin Schiff Base Ligands

Meiju Niu; Zhen Li; Guoliang Chang; Xiangjin Kong; Min Hong; Qing-fu Zhang

Two new zinc complexes, Zn(HL1)2 (1) and [Zn2(H2L2)(OAc)2]2 (2) [H2L1 = Schiff base derived from o-vanillin and (R)-(+)-2-amino-3-phenyl-1-propanol, H3L2 = Schiff base derived from o-vanillin and 2-amino-2-ethyl-1,3-propanediol], have been synthesized and characterized by single crystal X-ray diffraction, elemental analyses, TG analyses, solid fluorescence, IR, UV-Vis and circular dichroism spectra. The structural analysis shows that complex 1 has a right-handed double helical chain along the crystallographic b axis. A homochiral 3D supramolecular architecture has been further constructed by intermolecular C-H··· π, O-H···O and C-H···O interactions. Complex 2 includes two crystallographically independent binuclear zinc molecules. The two binuclear zinc molecules are isostructural. The 2-D sheet supramolecular structure was formed by intermolecular hydrogen bonding interaction. The fluorescence of ligands and complexes in DMF at room temperature are studied. The interactions of two complexes with calf thymus DNA (CT-DNA) are investigated using UV-Vis, CD and fluorescence spectroscopy. The results show that complex 1 exhibits higher interaction with CT-DNA than complex 2. In addition, in vitro cytotoxicity of the complexes towards four kinds of cancerous cell lines (A549, HeLa, HL-60 and K562) were assayed by the MTT method. Investigations on the structures indicated that the chirality and nuclearity of zinc complexes play an important role on cytotoxic activity.


RSC Advances | 2016

Two chiral alkanolamine Schiff base Cu(II) complexes as potential anticancer agents: synthesis, structure, DNA/protein interactions, and cytotoxic activity

Meiju Niu; Zhen Li; Xiao Li; Xianqiang Huang

Two Schiff base copper(II) complexes, [Cu(R-L) (CH3OH)]8 (1) and [Cu(S-L) (CH3OH)]4 (2) {[R/S-H2L = R/S-3-phenyl-2-(2-hydroxy-5-chlorobenzylideneamino)propane-1-ol]}, have been successfully achieved and fully characterized by single-crystal X-ray diffraction (SXRD), mass spectrometry (MS), Fourier transform infrared spectroscopy (FT-IR), and elemental analysis (EA). The interactions of complexes 1 and 2 with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) have been comprehensively investigated using various electronic absorption spectroscopies. The thermal denaturation, viscosity, and UV-Vis spectra data suggested non-intercalative binding between DNA and the complexes. Additionally, an in vitro cytotoxicity test on the two complexes towards four types of human cancerous cell lines (HL-60, Caco-2, A549, and HeLa) indicated that the two complexes exhibited substantial cytotoxic activity. Especially, complex 2 exhibited excellent data, with IC50 = 10.97 ± 1.22 against HL-60 cells, which indicated that the two chiral complexes play significant roles in the cytotoxicity and interactions with DNA and BSA.

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Min Hong

Liaocheng University

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Zhen Li

Liaocheng University

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Kai Liu

Liaocheng University

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