Meinhard Robinow

Aicardi syndrome, papilloma of the choroid plexus, cleft lip, and cleft of the posterior palate.

ccrcbrospinal fluid and other clinical specimens. J Clin Microblol 14:201, 1981. I I. Eisenach KD, French DE, Jimenez JF: Comparison of acridine orange and Gram stains for direct smears of cerebrospinal fluid. American Society for Microbiology Annual Meeting, Dallas, 1981. 12. Waring WW, .leansonne LO II1: Practical manual of pediatrics. St. Louis, 1982, CV Mosby, pp 454-5. 13. Sarff LD, Platt LH, McCracken GH: Ccrebrospinal fluid evaluation in neonates: Comparison of high-risk infants with and without meningitis. J PEDIATR 88:473, 1976. 14. Paik G: Reagents, stains, and miscellaneous test procedures. In Lennette Ell, editor: Manual of clinical microbiology. Washington, DC, 1980, American Society for Microbiology, p 1016.

Autosomal dominant ectrodactyly and absence of long bones of upper or lower limbs: Further clinical delineation

The association of ectrodactyly and absence of long bones of the upper or lower extremities has been recognized previously in nine families. We report 24 additional individuals in four families who are similarly affected. Two of these families manifest the unusual feature of unilateral preaxial polydactyly of a lower extremity. Data from these four families plus the nine previously reported suggest that ectrodactyly associated with absence of long bones of the upper or lower limbs is a genetically determined disorder, inherited as an autosomal dominant trait with widely variable expression or nonpenetrance.

Adverse Effects of Foods in Genetic Disorders

Most products of food metabolism have adverse effects on health if their concentrations in blood and extra- and intracellular fluids exceed narrow physiologic limits. Homeostasis, the maintenance of normal concentrations, is achieved by a vast number of genetically determined enzymatic processes that regulate digestion, absorption, transport, intermediate metabolism, and excretion.