Melandri P

[A comparative immunoelectrophoretic study on extracts of LS fibroblasts and of tumors produced by inoculating them into C3H mice (author's transl)].

Aqueous extracts of LS fibroblasts (LS) and of tumors obtained by inoculating these cells into newborn C3H mice (Tu/LS) share a number of antigens detectable by means of Immunoelectrophoresis against rabbit anti-LS or anti-Tu/LS sera. Yet, at least one antigen seems to be contained only in the LS extracts; in fact, anti-LS sera, absorbed with Tu/LS extracts, reacted with the LS extracts, causing a precipitation line on Immunoelectrophoresis. This may depend on the suppression from the growing population of the inoculated cells of a line more incompatible or in any case less favored in the environment of the subcutaneous tissue of the living animal; or on the lack of in vivo production of an antigen that the LS fibroblast sinthesizes when growing in vitro.