Mélèze Hocini
ESPCI ParisTech
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Featured researches published by Mélèze Hocini.
Cardiac Electrophysiology (Fourth Edition)#R##N#From Cell to Bedside | 2004
Michel Haïssaguerre; Prashanthan Sanders; Pierre Jais; Mélèze Hocini; Dipen Shah; Jacques Clementy
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans, occurring in 2% of the unselected adult population, increasing with each decade of life to a prevalence of 5.9% in the population older than 65 years. It results in an increased mortality rate and significant morbidity rate related to thromboembolic stroke, loss of atrial systole, and tachycardia-mediated atrial and ventricular cardiomyopathy. 1 Management strategies have been two tiered, either using palliative measures of rate control coupled with anticoagulation or the restoration and maintenance of sinus rhythm. Emerging evidence suggests that the pharmacologic maintenance of sinus rhythm has limited efficacy and value, at least in older patients and in those with persistent AF or structural heart disease. 2 3 4 Consequently, there is heightened interest in the nonpharmacologic, catheter-based approaches to maintain sinus rhythm that may prevent the significant adverse consequences associated with this arrhythmia. This chapter focuses on the current mapping techniques and the advantages and limitations of catheter ablation techniques targeting the triggers and substrate of AF.
Archive | 2013
Nicolas Derval; Frédéric Sacher; Ashok Shah; Sébastien Knecht; Mélèze Hocini; Pierre Jais; Michel Haïssaguerre
Early repolarization (ER) involving the inferolateral leads, previously considered a benign electrocardiographic (ECG) phenomenon, has recently been associated with sudden cardiac death. Although the mechanisms underlying early repolarization are unknown, ER is the latest of the primary electrical cardiac disease discovered to have significantly high prevalence in SCD cases and contribute to increased risk of death from cardioarrhythmic cause. Population-based studies have demonstrated an association between early repolarization and sudden death, primarily when the ECG demonstrates ≥0.2 mV of ST elevation. Risk stratification, especially for asymptomatic patient, remains challenging. However, clinical features as personal history of syncope, familial history of sudden cardiac death and characteristics of the J-wave (>0.2 mV, wide distribution, horizontal/descending ST segment) should be considered at higher risk.
Archive | 2008
Frederic Sacher; Mélèze Hocini; Anders Jonsson; Pierre Jais; Dominique Lacroix; Mark D. O’Neill; Yoshihide Takahashi; Nicolas Derval; Julien Laborderie; Pierre Bordachar; Jacques Clémenty; Michel Haïssaguerre
As in atrial fibrillation (AF), while both triggers and substrate may theoretically be the target of catheter ablation strategies, the presently published literature on catheter ablation of ventricular fibrillation (VF), including isolated case reports, has focused on targeting triggers.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11The large mass of ventricular myocardium, the importance of maintaining normal mechanical ventricular function, and the risk of creating other forms of malignant arrhythmias mean that ablation strategies aimed at substrate modification are not suitable using the currently available technology. However, previous work in AF has shown that both triggers and substrate may share a close structural relationship. The pulmonary veins play an important role in the initiation and maintenance of AF,12 and recent studies have shed light on their role in the maintenance of AF in some patients. Similarly, several experimental studies demonstrated that Purkinje fibers act as initiators and perpetuators of VF.13,14 Hence, by ablating an area in which the triggering ectopics are found to originate, an additional effect might be substrate modification if the area is implicated in the maintenance of VF.
computers in cardiology conference | 2009
Rémi Dubois; Pierre Roussel; Mélèze Hocini; Frédéric Sacher; Michel Haïssaguerre; Gérard Dreyfus
Archive | 2012
Randell L. Werneth; Mélèze Hocini; Mark T. Stewart; Dan Wittenberger; Timothy J. Corvi; Michael Lau; Vinod Sharma
6th International Conference on Mass Data Analysis of Image and Signals in Medicine, Biotechnology, Chemistry and Food Industry MDA 2011 | 2011
Oriol Pont; Michel Haïssaguerre; Hussein Yahia; Nicolas Derval; Mélèze Hocini
Catheter Ablation of Cardiac Arrhythmias (Second Edition) | 2011
Isabelle Nault; Prashanthan Sanders; Ashok Shah; Nick Linton; Amir Jadidi; Sébastien Knecht; Matthew Wright; Andrei Forclaz; Mélèze Hocini; Pierre Jais; Michel Haïssaguerre
Archive | 2010
Michel Haïssaguerre; Michael Lau; Randell L. Werneth; Timothy J. Corvi; Sumita Bhola; Mark T. Stewart; Mélèze Hocini
Cardiac Electrophysiology: From Cell to Bedside (Seventh Edition) | 2018
Nathaniel Thompson; Antonio Frontera; Masateru Takigawa; Arnaud Denis; Nicolas Derval; Mélèze Hocini; Pierre Jais; Michel Haïssaguerre
Cardiac Electrophysiology: From Cell to Bedside (Seventh Edition) | 2018
Pierre Jais; Ashok Shah; Rémi Dubois; Mélèze Hocini; Michel Haïssaguerre