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Dive into the research topics where Melwyn Abreo is active.

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Featured researches published by Melwyn Abreo.


Bioorganic & Medicinal Chemistry Letters | 1999

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

Nan-Horng Lin; Melwyn Abreo; David E. Gunn; Suzanne A. Lebold; Edmund L. Lee; James T. Wasicak; Ann-Marie Hettinger; Jerome F. Daanen; David S. Garvey; Jeffrey E. Campbell; James P. Sullivan; Michael D. Williams; Stephen P. Arneric

Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).


Journal of Medicinal Chemistry | 1996

Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors

Melwyn Abreo; Nan-Horng Lin; David S. Garvey; David E. Gunn; Ann-Marie Hettinger; James T. Wasicak; Patricia A. Pavlik; Yvonne C. Martin; Diana L. Donnelly-Roberts; David J. Anderson; James P. Sullivan; Michael T. Williams; Stephen P. Arneric; Mark W. Holladay


Archive | 2004

Pyridazine derivatives and their use as therapeutic agents

Nagasree Chakka; Mikhail Chafeev; Sultan Chowdhury; Jianmin Fu; Duanjie Hou; Rajender Kamboj; Vishnumurthy Kodumuru; Shifeng Liu; Vandna Raina; Shaoyi Sun; Serguei Sviridov; Michael D. Winther; Zaihui Zhang; Melwyn Abreo; Mark W. Holladay; Wenbao Li; Sengen Sun; Chi Tu; Heinz W. Gschwend


Archive | 1993

Heterocyclic ether compounds that enhance cognitive function

Melwyn Abreo; David E. Gunn; Nan-Horng Lin; Richard L. Elliott; David S. Garvey; Suzanne A. Lebold; James T. Wasicak


Archive | 2004

Piperazine derivatives and their use as therapeutic agents

Serguei Sviridov; Vishnumurthy Kodumuru; Shifeng Liu; Melwyn Abreo; Michael D. Winther; Heinz W. Gschwend; Rajender Kamboj; Shaoyi Sun; Mark W. Holladay; Wenbao Li; Chi Tu


Archive | 2004

Pyridyl derivatives and their use as therapeutic agents

Melwyn Abreo; Daniel F. Harvey; Mikhail A. Kondratenko; Wenbao Li; Rajender Kamboj; Vishnumurthy Kodumuru; Michael D. Winther; Heinz W. Gschwend; Nagasree Chakka; Shifeng Liu; Serguei Sviridov; Shaoyi Sun


Archive | 1995

3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release

Melwyn Abreo; David E. Gunn; Nan-Horng Lin; David S. Garvey; Mark W. Holladay; Keith B. Ryther


Archive | 1995

Heterocyclic ether compounds useful in controlling neurotransmitter release

Nan-Horng Lin; Mark W. Holladay; Melwyn Abreo; David E. Gunn; Suzanne A. Lebold; Richard L. Elliott; Yun He


Archive | 2005

Non-nucleotide composition and method for inhibiting platelet aggregation

Robert Plourde; Sammy Ray Shaver; James G. Douglass; Paul S. Watson; José L. Boyer; Chi Tu; Melwyn Abreo; Lorenzo Josue Alfaro-Lopez; Yangbo Feng; Daniel F. Harvey; Tatyana V. Khasonova


Archive | 1998

Heterocyclic ether and thioether compounds useful in controlling chemical synaptic transmission

Mark W. Holladay; Melwyn Abreo; David E. Gunn; Nan-Horng Lin; David S. Garvey; Keith B. Ryther; Suzanne A. Lebold; Richard L. Elliott; Yun He; James T. Wasiak; Hao Bai; Michael J. Dart; Paul Ehrlich; Yihong Li; John F. Kincaid; Jeffrey M. Schkeryantz; John K. Lynch

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