Is this you? Create Your Porfile
Avatar

Melwyn Abreo

Durham University

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Melwyn Abreo is active.

Explore More

Publication

Featured researches published by Melwyn Abreo.

Bioorganic & Medicinal Chemistry Letters | 1999

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

Nan-Horng Lin; Melwyn Abreo; David E. Gunn; Suzanne A. Lebold; Edmund L. Lee; James T. Wasicak; Ann-Marie Hettinger; Jerome F. Daanen; David S. Garvey; Jeffrey E. Campbell; James P. Sullivan; Michael D. Williams; Stephen P. Arneric

Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).

Journal of Medicinal Chemistry | 1996

Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors

Melwyn Abreo; Nan-Horng Lin; David S. Garvey; David E. Gunn; Ann-Marie Hettinger; James T. Wasicak; Patricia A. Pavlik; Yvonne C. Martin; Diana L. Donnelly-Roberts; David J. Anderson; James P. Sullivan; Michael T. Williams; Stephen P. Arneric; Mark W. Holladay

Archive | 2004

Pyridazine derivatives and their use as therapeutic agents

Nagasree Chakka; Mikhail Chafeev; Sultan Chowdhury; Jianmin Fu; Duanjie Hou; Rajender Kamboj; Vishnumurthy Kodumuru; Shifeng Liu; Vandna Raina; Shaoyi Sun; Serguei Sviridov; Michael D. Winther; Zaihui Zhang; Melwyn Abreo; Mark W. Holladay; Wenbao Li; Sengen Sun; Chi Tu; Heinz W. Gschwend

Archive | 1993

Heterocyclic ether compounds that enhance cognitive function

Melwyn Abreo; David E. Gunn; Nan-Horng Lin; Richard L. Elliott; David S. Garvey; Suzanne A. Lebold; James T. Wasicak

Archive | 2004

Piperazine derivatives and their use as therapeutic agents

Serguei Sviridov; Vishnumurthy Kodumuru; Shifeng Liu; Melwyn Abreo; Michael D. Winther; Heinz W. Gschwend; Rajender Kamboj; Shaoyi Sun; Mark W. Holladay; Wenbao Li; Chi Tu

Archive | 2004

Pyridyl derivatives and their use as therapeutic agents

Melwyn Abreo; Daniel F. Harvey; Mikhail A. Kondratenko; Wenbao Li; Rajender Kamboj; Vishnumurthy Kodumuru; Michael D. Winther; Heinz W. Gschwend; Nagasree Chakka; Shifeng Liu; Serguei Sviridov; Shaoyi Sun

Archive | 1995

3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release

Melwyn Abreo; David E. Gunn; Nan-Horng Lin; David S. Garvey; Mark W. Holladay; Keith B. Ryther

Archive | 1995

Heterocyclic ether compounds useful in controlling neurotransmitter release

Nan-Horng Lin; Mark W. Holladay; Melwyn Abreo; David E. Gunn; Suzanne A. Lebold; Richard L. Elliott; Yun He

Archive | 2005

Non-nucleotide composition and method for inhibiting platelet aggregation

Robert Plourde; Sammy Ray Shaver; James G. Douglass; Paul S. Watson; José L. Boyer; Chi Tu; Melwyn Abreo; Lorenzo Josue Alfaro-Lopez; Yangbo Feng; Daniel F. Harvey; Tatyana V. Khasonova

Archive | 1998

Heterocyclic ether and thioether compounds useful in controlling chemical synaptic transmission

Mark W. Holladay; Melwyn Abreo; David E. Gunn; Nan-Horng Lin; David S. Garvey; Keith B. Ryther; Suzanne A. Lebold; Richard L. Elliott; Yun He; James T. Wasiak; Hao Bai; Michael J. Dart; Paul Ehrlich; Yihong Li; John F. Kincaid; Jeffrey M. Schkeryantz; John K. Lynch

Explore More

Collaboration

Dive into the Melwyn Abreo's collaboration.

Top Co-Authors
Avatar

Chi Tu

Durham University

View shared research outputs
Top Co-Authors
Avatar

Mark W. Holladay

Durham University

View shared research outputs
Top Co-Authors
Avatar

Michael D. Winther

Novartis

View shared research outputs
Top Co-Authors
Avatar

Rajender Kamboj

Novartis

View shared research outputs
Top Co-Authors
Avatar

Shaoyi Sun

Novartis

View shared research outputs
Top Co-Authors
Avatar

Shifeng Liu

Novartis

View shared research outputs
Top Co-Authors
Avatar

Vishnumurthy Kodumuru

Novartis

View shared research outputs
Top Co-Authors
Avatar

Heinz W. Gschwend

Ciba Specialty Chemicals

View shared research outputs
Top Co-Authors
Avatar

Daniel F. Harvey

Durham University

View shared research outputs
Top Co-Authors
Avatar

Nagasree Chakka

Amgen

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge