Meral Oruc

Evaluation of lung function on impulse oscillometry in preschool children born late preterm.

There is a paucity of data on lung physiology in late‐preterm children, who may be exposed to a risk of decline in lung function during childhood. In this study, we evaluated lung function in preschool children born late preterm using impulse oscillometry (IOS), and compared the results with those obtained in healthy term‐born children.

Neonatal sepsis and simple minor neurological dysfunction

This study examined potential risk factors for and consequences of simple minor neurological dysfunction (SMND), in a group of very low‐birthweight newborns followed until preschool age.

Evaluation of lung function in preschool children born late‐preterm with impulse oscillometry

There is a paucity of data on lung physiology in late‐preterm children, who may be exposed to a risk of decline in lung function during childhood. In this study, we evaluated lung function in preschool children born late preterm using impulse oscillometry (IOS), and compared the results with those obtained in healthy term‐born children.

750 Determining the Mean Cord Blood Immature Platelet Fraction (IPF) of Healthy Newborns

Thrombocytopenia is the most common hematologic abnormality in newborn infants Immature platelet fraction (IPF) shows megakaryopoetic activity. The purpose of this study is to provide non-invasive new approach to thrombocytopenic infants for further studies by determining the normal levels of the mean cord blood IPF of healthy newborns. Methods Healthy newborns who were born at Kocaeli University in 2012, took place in this study. One ml of cord blood was obtained into EDTA tubes. Platelet counts and the mean IPF levels were studiedstudied with XE-100 (Sysmex) device. If taking blood to detect blood group is needed in 24–48 hours, IPF levels have been reworked. Results A total of 75 infants were enrolled in this study. Mean gestational age 37.5, birth weight 3032g, platelet count 234.000/mm3, average levels of cord blood IPF 5.19%, IPF level in48th hour were found to be 4.3%. Discussion In healthy adults, the normal values of IPF has been reported as 3.4% on average from 1.1 to 6.1%. Increased levels of IPF are shown to be related to increased platelet production; particularly in disorders related to the destruction of platelets and normal and low values of IPF are shown to be related to decreased platelet production conditions. There are limited number of researches which investigate IPF values in neonates. Conclusion In this study we found average levels of cord blood is IPF 5.19%. Determining the right approach to thrombocytopenic patients will be possible by recognizing the normal ranges of IPF values in healthy newborns.

1257 The Neurodevelopmental Assessment of Very Low Birth Weight Infants at 4–6 Years of Age

The major and minor neurodevelopmental morbidities among premature infants become an important issue because of the increase in the number of surviving premature newborns. The Aim of this study was to examine the cognitive, neuromotor, emotional and behavioral outcomes of the premature newborns at 4–6 years of age born with very low birth weight and to investigate the relationship between neuromotor and neurocognitive development. The neuromotor status of 68 children were evaluated according to Touwen neurological examination, 64 children were assessed using Stanford-Binet and Peabody Picture Vocabulary Test, 65 children using Strength and Difficulties Questionnaire and Vineland Adaptive Behavior Scale. Three cases were already diagnosed and followed as CP. According to Touwen examination 28 (%41.2) children were normal, 35 (%51.5) had simple minor neurological dysfunction (MND), 2 (%2.9) had complex MND. The mean IQ score was 90.1±10.9. The rate of hyperactivity, behavioral problems and emotional problems were in order %60, %33.8 and %53.8. The children were diagnosed as having a delay of 14.9±10.6 month for conducting, 10.6±8.6 month for daily activities, 10.7±11.5 month for social competence and a delay of 6.3±10.2 month for motor behavior. The cognitive and neuropsychological results of the 35 children with MND and 28 children with normal neuromotor status were compared. The children with MND had significanly lower mean IQ score, more delay for motor behavior and they were more hyperactive. Majority of the children who were considered as normal had cognitive impairment, language, behavior/emotional and neuromotor problems in various degrees.

1275 The Neurodevelopmental Assessment of Very Low Birth Weight Infants at 4–6 Years of Age and the Relationship with Risk Factors

The major and minor neurodevelopmental morbidities among premature infants become an important issue because of the increase in the number of surviving premature newborns, especially in the smaller gestational age group. The aim of this study was to examine the neuromotor outcome of the premature newborns at 4–6 years of age born with very low birth weight and to investigate the risk factors associated with this outcome. The present study was conducted in 70 very low birth weight children born during april 2004 and june 2007. The neuromotor status of 68 children were evaluated according to Touwen. The hospital records of the children were scanned for various risk factors. Three cases were already diagnosed and followed as CP. The remaining 65 children did not meet the criteria for CP. According to Touwen examination 28 (%41.2) children were considered as normal, 35 (%51.5) had simple minor neurological dysfunction, 2 (%2.9) had complex minor neurological dysfunction. 35 children with minor neurological dysfunction and 28 children with normal neuromotor status were compared for some risk factors. The children with minor neurological dysfunction had significantly lower Apgar score, their hosipitalization period was longer and the diagnosis rate of clinical (%73.5; %25) and culture proven sepsis (%47.1; %10.7) was higher in this group. Sepsis was significantly associated with adverse neurological outcome. The prevention of neonatal sepsis in NICUs will increase the chance for healthy neurological development.

1775 The Evaluation of Lung Function Measured by Impulse Oscillometry Method in very low Birth Weight Born Children at Preschool Age

Chronic lung disease is one of the most important complications of prematurity and results in short and long-term morbidity. Survival of more prematurely born babies leads to an increase in the incidence of bronchopulmonary dysplasia (BPD). The Aim of this study is to evaluate the lung function of babies who were born under birth weight of 1500 grams using impulse oscillometry in preschool age. Eighty-six children who were 3–6 years old and followed in our neonatology clinic (born under birth weight of 1500 grams) were enrolled in the study as the patient group and 40 term-born healthy children as the control group. The demographic data of the patients, duration of mechanical ventilation and oxygen therapy and presence of BPD were recorded. After routine physical examination, lung functions of the patients were measured by impulse oscillometry. The data were evaluated by SPSS 16 program. Forty-nine (57%) of 86 patients were non-BPD, 20 were mild BPD, 14 were moderate BPD and 3 were severe BPD. Weight and height of pramature and control groups were similar. There was a statistically significant difference between the two groups in terms of resistance (R5, R10, R20), reactance (X5, X10, X20) and resonant frequency (fres). The airway resistance was significantly higher and reactance was significantly lower in the premature group. However, there was no difference between BPD and non-BPD groups. In conclusion; although premature babies can catch-up their peers at 3–4 years old in terms of their body percentiles, their lungs still reflect the traces of prematurity.