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Featured researches published by Mertol Gokce.


Medical Oncology | 2012

Accuracy of positron emission tomography in mediastinal node assessment in coal workers with lung cancer.

Özkan Saydam; Mertol Gokce; Ali Kılıçgün; Ozgur Tanriverdi

The purpose of this study was to explore the accuracy of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) in the assessment of mediastinal lymph node in coal workers who had non-small cell lung cancer. We retrospectively reviewed 42 retired coal workers who had lung cancer without distant metastasis, between May 2007 and May 2010. Regarding the mediastinal lymph nodes, when the standard uptake value was greater than 2.5, it was considered “malignancy positive.” After histological examination of the mediastinal lymph nodes, anthracotic and metastatic ones were detected. The results of PET/CT were analyzed to determine its accuracy. Of these 42 patients, PET/CT detected 47 positive mediastinal lymph nodes in 24 patients with a mean SUV maximum of 6.2 (2.6–13.8). One hundred and thirty-one mediastinal lymph node foci were dissected. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FDG-PET/CT in detecting nodal metastases were 84% (16/19), 65% (15/23), 66% (16/24), 83% (15/18), and 74% (31/42) on a per-patient basis, respectively. Mediastinal node staging with FDG-PET/CT in coal workers is insufficient due to the high false-positive rates due to the presence of pneumoconiosis. In these patients, an invasive technique such as mediastinoscopy seems mandatory for confirmation of ipsilateral or contralateral mediastinal lymph node metastasis.


Journal of Cardiothoracic Surgery | 2012

Antioxidant vitamins C, E and coenzyme Q10 vs Dexamethasone: comparisons of their effects in pulmonary contusion model

Mertol Gokce; Özkan Saydam; Volkan Hancı; Murat Can; Burak Bahadir

BackgroundThe goal of our study is to evaluate the effects of antioxidant vitamins (vitamin C and E), Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC).MethodsRats were randomly divided into six groups. Except for the control, all subgroups had a moderate pulmonary contusion. Animals in the group I and group II received intraperitoneal saline, group III received 10mg.kg-1 CoQ10 group IV received 100mg.kg-1 vitamin C, group V received 150mg.kg-1 vitamin E, and group VI received 10mg.kg-1 Dxm. Blood gas analysis, serum nitric oxide (NO) and malondialdehyde (MDA) levels as well as superoxide dismutase (SOD) activity assays, bronchoalveolar lavage (BAL) fluid and histopathological examination were performed.ResultsAdministration of CoQ10 resulted in a significant increase in PaO2 values compared with the group I (p = 0.004). Levels of plasma MDA in group II were significantly higher than those in the group I (p = 0.01). Early administration of vitamin C, CoQ10, and Dxm significantly decreased the levels of MDA (p = 0.01). Lung contusion due to blunt trauma significantly decreased SOD activities in rat lung tissue compared with group I (p = 0.01). SOD levels were significantly elevated in animals treated with CoQ10, Vitamin E, or Dxm compared with group II (p = 0.01).ConclusionsIn our study, CoQ10, vitamin C, vitamin E and Dxm had a protective effect on the biochemical and histopathological outcome of PC after experimental blunt thorax trauma.


Kaohsiung Journal of Medical Sciences | 2013

Effect of ghrelin on inflammatory response in lung contusion.

Berrak Guven; Mertol Gokce; Özkan Saydam; Murat Can; Sibel Bektas; Serhan Yurtlu

The purpose of this study was to investigate the effects of ghrelin on inflammatory response and tissue damage following trauma‐induced acute lung injury. Thirty male wistar albino rats (300–400 g) were randomly assigned into three groups: control group (n = 6), lung contusion plus saline (saline‐treated, n = 12), and lung contusion plus ghrelin (ghrelin‐treated, n = 12). Saline‐ or ghrelin‐treated traumatic rats were sacrificed at two time points (24 and 72 hours) after lung contusion. Blood was collected for the analysis of serum adenosine deaminase (ADA). Tissue transforming growth factor‐beta 1 (TGF‐β1) and matrix metalloproteinase‐2 (MMP‐2) levels were measured by enzyme‐linked immunosorbent assay and histopathological examination was performed on the lung tissue samples. Our results indicated that ghrelin significantly reduced morphologic damages. Serum ADA activities were significantly decreased after lung contusion and this decline started early with ghrelin treatment. TGF‐β1 and MMP‐2 levels in lung tissue were elevated at 72 hours after lung contusion and treatment with ghrelin significantly increased TGF‐β1 level and reduced MMP‐2 level. In conclusion, our study demonstrates that acute lung injury initiated proinflammatory responses and ghrelin administration showed an anti‐inflammatory effect in lung contusion.


Journal of Clinical and Analytical Medicine | 2013

Mediastinal Masses; the Analysis of 28 Cases in the Western Black Sea Region

Mertol Gokce; Özkan Saydam; Ali Kılıçgün; Sami Karapolat; Suat Gezer

DOI: 10.4328/JCAM.910 Received: 31.01.2012 Accepted: 29.02.2012 Printed: 01.03.2013 J Clin Anal Med 2013;4(2): 93-5 Corresponding Author: Mertol Gökçe, Karaelmas Üniversitesi Tıp Fakültesi; Göğüs Cerrahisi Anabilim Dalı. 67400 Zonguldak, Türkiye. T.: +905324070788 E-Mail: [email protected] Özet Amaç: Mediastinal kitleler hayati organlara yakın olması ve çeşitli histopatolojik tipler içermesinden dolayı çok önemlidir. Bu çalışmanın amacı, cerrahi olarak tanı konulan ve rezeksiyon yapılan mediastinal kitleli olguları retrospektif olarak analiz etmektir. Gereç ve Yöntem: Mayıs 2008-Aralık 2011 tarihleri arasında, Batı Karadeniz bölgesinde ki üniversite hastaneleri göğüs cerrahisi kliniklerimizde mediastinal kitle nedeniyle operasyon uygulanan 28 hasta retrospektif olarak incelendi. Olgular yaş, cinsiyet, şikâyet, klinik ve radyolojik bulgular, cerrahi yaklaşım, histopatolojik tanı, postoperatif komplikasyon ve mortalite açısından incelendi. Olguların yaş aralığı 31-76 arasında (ortalama: 52,07) ve 19’u kadın, 9’u erkek toplam 28 hastadan oluşuyordu. Başvuru şikâyetleri öksürük, göğüs ağrısı, kas güçsüzlüğü ve dispne idi. Bir olguda vena kava süperior sendromu vardı. Olguların %21,4’ü asemptomatikti. Olguların %85,72’sine komplet rezeksiyon yapılırken, %14,28’ine ise yalnızca biyopsi yapılabildi. Postoperatif komplikasyon bir olguda görüldü ve mortalite izlenmedi. Sonuç: Cerrahi tedavi, mediastinal kitlelerin kesin tanı ve tedavisinde düşük mortalite ve morbidite oranı ile güvenilir bir yöntemdir.


Medical Journal of Western Black Sea | 2018

Hidatik Kist Hastalığı

Osman Korcan Tilkan; Serkan Uysal; Mertol Gokce

Hidatik kist hastaligi (HKH); cogunlukla gelismekte olan ve hayvanciligin yaygin oldugu ulkelerdeki koruyucu hekimligin yetersizligi ile ortaya cikan bir cesit ekinokok cestodunun neden oldugu paraziter hastaliktir. En sik etoburlarin diskisi ile etrafa yayilan yumurtalarin otcul hayvanlara ve insanlara bulasmasi ile ortaya cikar. En sik karacigerde gorulebilmekle birlikte burada tutunamaz ise sistemik yayilim ile akcigere ve tum vucuda yayilabilmektedir. Tanida en cok direkt akciger grafisi ve akciger bilgisayarli tomografi kullanilmakta olup tedavisi siklikla cerrahidir


Respiratory medicine case reports | 2015

Chylothorax due to leukemic infiltration in a patient with chronic lymphocytic leukemia.

Hakan Tanrıverdi; Firat Uygur; Osman Korcan Tilkan; Mertol Gokce; Meltem Tor

Chylothorax is characterized by accumalation of milky fluid called chyle into the plural space. Most common causes of cyhlothorax are trauma or surgery of thoracic duct and malignancies. Among the malignancies lymphoma is responsible approximately 70% of cyhlothorax but other lymphocytic tumors including chronic lymphocytic leukemia (CLL) is rarely reported. A 71 years old man with known CLL, presented with dispnea and pleural effusion and diagnosed cyhlothorax due to leukemic infiltration that confirmed by immuno flow cytometric analyse.


Journal of Clinical and Analytical Medicine | 2013

Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion

Berrak Guven; Murat Can; Mertol Gokce; Özkan Saydam

DOI: 10.4328/JCAM.979 Received: 03.04.2012 Accepted: 09.05.2012 Printed: 01.05.2013 J Clin Anal Med 2013;4(3): 216-8 Corresponding Author: Berrak Guven, Karaelmas University of Medicine, Department of Biochemistry, Zonguldak, Turkey. T.: +90 3722612839 F.: +90 3722610155 E-Mail: [email protected] Özet Amaç: Akciğer kontüzyonlu ratların serumlarında adenozin deaminaz (ADA) izoenzimlerinin aktivitelerini araştırmayı amaçladık. Gereç ve Yöntem: On iki tane erkek wistar albino sıçanda toraks üzerine hareketli platform ile 50 cm yükseklikten bir silindirik ağırlık bırakılarak akciğer kontüzyonu oluşturuldu. Travmadan 24 saat (n=6) ve 72 saat (n=6) sonra sıçanlar öldürüldü. Kontrol (n=6) (travma uygulanmayan) ve travmatik sıçanların serumlarında ADA izoenzimleri ölçüldü. Bulgular: Bizim sonuçlarımız kontüzyon sonrası 72 saatte serum total ADA aktivitelerinde önemli derecede azalma olduğunu göstermiştir. Kontüzyon sonrası 24 ve 72 saatteki ADA1 aktivitesinde kontrolle karşılaştırıldığında önemli bir düşüş vardır. Diğer taraftan, 24 ve 72 saatte ADA2 aktivitesindeki artış istatistiksel olarak anlamlı değildir. Sonuç: Sonuç olarak, serum ADA2 izoenzimi akciğer kontüzyonunda inflamatuvar yanıt nedeniyle baskın izoenzim haline gelmiştir. Ancak serum ADA1 aktivitesini etkileyen düzenleyici mekanizmaları açıklamak için ileri çalışmalara ihtiyaç duyulmaktadır.


Tüberküloz ve toraks | 2009

CT-guided transthoracic fine needle aspiration of pulmonary lesions: Accuracy and complications in 134 cases

Bahadir T. Uskul; Hatice Türker; Mertol Gokce; Aydın Kant; Sinan Arslan; Fatma Emre Turan


Medical Oncology | 2015

The palliative treatment with intrapleural streptokinase in patients with multiloculated malignant pleural effusion: a double-blind, placebo-controlled, randomized study.

Özkan Saydam; Kemal Karapinar; Mertol Gokce; Lutfiye Kilic; Muzaffer Metin; Ibrahim Ilker Oz; Ozgur Tanriverdi


Turkish Thoracic Journal/Turk Toraks Dergisi | 2010

A Case of Carcinoid Tumor who Underwent Lobar Carina Resection and Reconstruction

Erdal Okur; Volkan Baysungur; Mertol Gokce; Semih Halezeroglu

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Özkan Saydam

Zonguldak Karaelmas University

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Murat Can

Zonguldak Karaelmas University

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Ali Kılıçgün

Abant Izzet Baysal University

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Berrak Guven

Zonguldak Karaelmas University

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Burak Bahadir

Zonguldak Karaelmas University

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Gamze Yurdakan

Zonguldak Karaelmas University

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Meltem Tor

Zonguldak Karaelmas University

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Osman Korcan Tilkan

Zonguldak Karaelmas University

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Ali Ugur Emre

Zonguldak Karaelmas University

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