Mervin Silverberg
Montreal Children's Hospital
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Featured researches published by Mervin Silverberg.
Journal of Pediatric Surgery | 1985
Garth Alperstein; Fredric Duam; Stanley E. Fisher; Harvey Aiges; James Markowitz; Jerrold M. Becker; Henry So; David L. Schwartz; Mervin Silverberg; Keith M. Schneider
Studies of the effect of surgery on growth failure in adolescents with Crohns disease have revealed conflicting data. To better determine the role of surgery for growth delay, growth data from 26 patients with Crohns disease with intestinal resections and/or ileostomies were reviewed, 3 of whom had surgery twice. Operations were performed on 14 Tanner Stage I, 1 Tanner II, 1 Tanner III, and 13 Tanner IV or V patients. In the prepubertal group, 13 of the 14 had growth impairment, only one of whom had surgery primarily for that growth failure. One year after operation, 11 of 13 Tanner I growth failure patients experienced an increase in height velocity of 5.38 +/- 1.18 cm/yr (mean +/- SE;P less than 0.01); 9/11 achieved normal height velocity for Tanner I. Two attained their preillness height percentiles at one year follow-up, while 5 patients attained their preillness height percentiles 2.5 to 10 years following surgery. Of the four who failed to achieve normal height velocity, 3 had early recurrence of active disease. The Tanner Stage II and III patients both had growth failure, and both had a growth spurt following surgery. Of those who were Tanner Stage IV or V at the time of surgery, 5 of 13 had growth failure. Following surgery, none had an increase in height velocity. These data suggest that when patients with Crohns disease and growth failure are prepubertal and surgery is performed primarily because of failure of medical therapy and/or other complications, a postoperative growth spurt may be expected within one year.
Journal of Pediatric Gastroenterology and Nutrition | 1982
James Markowitz; Eugene Aronow; Aaron R. Rausen; Harvey Aiges; Mervin Silverberg; Fredric Daum
Chronic granulomatous disease of childhood (CGD), a hereditary disorder of neutrophil function, affects the gastrointestinal tract in a variety of ways. Esophageal involvement has only rarely been reported. An 11-year-old boy with CGD and progressive esophageal dysmotility is described. Repeated radiographic, endoscopic, and motility studies revealed a markedly atonic esophagus with varying function of the lower esophageal sphincter. Pharmacologic therapy and esophageal dilatations were unsuccessful in establishing adequate esophageal function. A feeding gastrostomy was required for nutritional support.
Journal of Pediatric Gastroenterology and Nutrition | 1985
Marie-Agnes LaSala; Fima Lifshitz; Mervin Silverberg; Raul A. Wapnir; Eduvigis Carrera
Magnesium metabolism was studied in seven patients with severe chronic inflammatory disease of the bowel (CIDB), and in 20 children without intestinal pathology. Four of the CIDB patients had ulcerative colitis and three had granulomatous disease of the bowel. All had diarrhea as well as other gastrointestinal complaints for 1 to 6 years prior to the study. All were being treated with sulfasalazine and were also receiving corticosteroids intermittently. All but one had had intestinal surgery. Basal plasma and urine were obtained in all patients and, if surgery was performed, a piece of muscle was excised. The CIDB patients received an intravenous magnesium infusion of 2 mEq/kg/day for 4 days, 2 days postsurgery. Electrocardiograms were recorded throughout the study. The mean basal plasma magnesium levels were reduced in CIDB patients as compared with controls. Mild hypomagnesemia was observed in six of seven CIDB patients. The mean basal urine excretion of magnesium was also reduced in CIDB patients, but the muscle concentrations of this element were similar to controls. Basal hypomagnesuria was present in only two of the three patients with granulomatous disease and in one patient with ulcerative colitis. The three patients with granulomatous disease excreted minimal amounts of magnesium in the urine during intravenous administration of this ion. A positive magnesium balance persisted throughout the 4-day period of infusion. In contrast, only two of the four patients with ulcerative colitis had magnesium retention during the first day of intravenous administration, and all four had negative magnesium balances thereafter. The data suggest that hypomagnesemia in CIDB patients may occur with or without magnesium deficiency. However, the excretion of magnesium in urine after a parenteral magnesium load was the best index of magnesium deficiency. In three CIDB patients, with involvement of small bowel, magnesium depletion was found.
The Journal of Pediatrics | 1969
Mervin Silverberg; Brian Wherrett; Ernest Worden; Peter Z. Neumann
Dietary and activity restrictions in children with nondebilitating diseases frequently result in frustrated parents and physicians. The present controlled study of infectious hepatitis suggests that in children who are not severely ill, supervised ad lib diets and activity regimens will not adversely affect the course of disease.
The Journal of Pediatrics | 1982
Saul Teichberg; James Markowitz; Mervin Silverberg; Harvey Aiges; Keith M. Schneider; Ellen Kahn; Fredric Daum
JAMA Pediatrics | 1967
Charles R. Scriver; Jean Larochelle; Mervin Silverberg
JAMA Pediatrics | 1966
Angeles Ramos; Mervin Silverberg; Leo Stern
Nature | 1966
Peter Neumann; Mervin Silverberg
The Journal of Pediatrics | 1979
Harvey Aiges; Ellen Kahn; Mervin Silverberg; Fredric Daum
Nature | 1967
Peter Neumann; Mervin Silverberg