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Featured researches published by Metin Caner.


Canadian Respiratory Journal | 2007

Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases

Halil Yanardag; Metin Caner; Irfan Papila; Sedat Uygun; Sabriye Demirci; Tuncer Karayel

A peripheral lymph node (PLN) 1 cm or greater was found in 79 of 546 sarcoidosis patients (14.5%) between 1972 and 2005. Seventy-two of the 79 sarcoidosis patients had a lymph node biopsy performed. Sixty-seven of these biopsy specimens were histologically diagnosed as sarcoidosis, whereas five patients had a reactive adenopathy. For patients with histological diagnosis of sarcoidosis, localizations of the biopsies were as follows: cervical (n=21), supraclavicular (n=20), inguinal (n=11), axillary (n=8), epitrochlear (n=5) and submandibular (n=2). At the time of biopsy, 12 patients had stage 0 disease, 37 patients had stage I disease, 14 patients had stage II disease and four patients had stage III disease. Skin involvement (16.4%) was the most frequently observed type of organ involvement in patients who had enlarged PLNs due to sarcoidosis. In the presence of an enlarged PLN in sarcoidosis, biopsy had a greater diagnostic value compared with other methods, as well as having a relatively low cost (approximately US


Southern Medical Journal | 2010

Ezetimibe therapy and its influence on oxidative stress and fibrinolytic activity.

Nurver Turfaner; Hafize Uzun; Huriye Balci; Meltem A. Ercan; Yesari Karter; Metin Caner; Fikret Sipahioglu; Habibe Genc

120) in Turkey. No procedure-related complications were observed. In conclusion, it is recommended that PLNs be thoroughly examined when sarcoidosis is suspected. If an enlarged PLN is found, biopsy should be routinely performed because it is an easy, convenient and practical method, with a low complication risk and a high sensitivity.


Otolaryngology-Head and Neck Surgery | 2006

Upper respiratory tract involvement of sarcoidosis in the Turkish population

Halil Yanardag; Murat Enoz; Irfan Papila; Sedat Uygun; Metin Caner; Tuncer Karayel

Objective: The effect of ezetimibe on blood lipids, oxidative stress, and fibrinolytic activity in hyperlipidemic patients was investigated after three months of therapy. Methods: Thirty hyperlipidemic patients were treated for twelve weeks with ezetimibe 10 mg/day. A healthy control group with matching age and gender was also included. Fasting blood glucose, lipid parameters, paraoxonase (PON1), protein carbonyl (PCO), oxidized LDL (oxLDL), 8-isoprostane (ISOPR), total antioxidant capacity (TAC) levels, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type-1 (PAI-1), and PAI-1/t-PA levels were evaluated. Results: Ezetimibe therapy for twelve weeks led to changes in lipid profile in accordance with the literature. Fibrinolytic activity parameters, PAI-1/tPA and tPA-1 decreased, whereas PAI-1 levels did not change significantly. Antioxidant parameters, serum PON1 activity, and TAC levels increased significantly compared with the basal values. Oxidant parameters, oxLDL, ISOPR, and PCO (which is an indicator of oxidative protein damage) decreased significantly after therapy. Conclusions: Ezetimibe therapy has beneficial effects on fibrinolytic activity and homeostasis between oxidant and antioxidant activity in hyperlipidemic patients This may be through lowering lipid levels or other mechanisms such as decreasing insulin resistance and the pleiotropic effects of the drug.


Chinese Journal of Physiology | 2013

Herbal Haemorrhoidal Cream for Haemorrhoids

Ebru Gurel; Savas Ustunova; Bulent Ergin; Nur Tan; Metin Caner; Osman Tortum; Cihan Demirci-Tansel

PRINCIPLES AND METHODS: Upper respiratory tract (URT) involvement is rare in sarcoidosis. In this descriptive study, we retrospectively evaluated the clinical and demographic features of 12 (2.19%) patients with URT involvement out of the 546 sarcoidosis patients with follow-up visits at our center within the last 40-year period. RESULTS: Out of the 546 patients, 12 (2.19%) had upper respiratory tract involvement, 5 (0.91%) had laryngeal involvement, 4 (0.73%) had sinonasal tract involvement, 2 (0.36) patients had salivary gland involvement, and 1 patient had tonsillary involvement. The number of stage 0 subjects among other sarcoidosis patients was significantly lower than that among those with URT involvement. CONCLUSIONS: URT involvement is rarely diagnosed in patients with systemic sarcoidosis. The most common site for URT involvement among the Turkish population is the larynx, followed by the sinonasal tract. EBM rating: C-4


Pharmacological Research | 2006

Montelukast protects against renal ischemia/reperfusion injury in rats

Goksel Sener; Ozer Sehirli; Ayliz Velioğlu-Öğünç; Sule Cetinel; Nursal Gedik; Metin Caner; Abdullah Sakarcan; Berrak Ç. Yeğen

Although hemorrhoids are one of the most common diseases in the world, the exact etiology underlying the development of hemorrhoids is not clear. Many different ointments are currently used to treat hemorrhoids; however, there is little evidence of the efficacy of these treatments to support their use. The aim of this study was to compare different herbal creams used for the treatment of hemorrhoids. Twenty-eight male Wistar albino rats, 6-8 weeks old and weighing 160-180 g, were used in this study as 1-control, 2-croton oil, 3-croton oil+fig leaves+artichoke leaves+walnut husks and 4-croton oil+fig leaves+artichoke leaves+walnut husks+horse chestnut fruit. After 3 days of croton oil application, rats were treated with 0.1 ml of cream or saline twice a day for 15 days by syringe. Tissue and blood samples were collected for histological, immunohistochemical and biochemical studies. Statistical significance was determined using one-way ANOVA followed by Tukeys multiple comparison tests. Croton oil administration resulted in severe inflammation. The third group showed partial improvement in inflammation; however, the greatest degree of improvement was seen in the fourth group, and some recovered areas were observed. Myeloperoxidase immunoreactivity was found to be decreased in the third and fourth groups compared to the second group. Additionally, biochemical analyses (Myeloperoxidase, Malondyaldehyde, nitrate/nitrite and nitrotyrosine levels and Superoxide Dismutase activity) were in agreement with the histological and immunohistochemical results. In conclusion, croton oil causes inflammation in the anal area and results in hemorrhoids. Treatment with our herbal hemorrhoid creams demonstrated anti-inflammatory and anti-oxidant effects in this model.


Chinese Journal of Physiology | 2007

Effects of coenzyme Q10 on the heart ultrastructure and nitric oxide synthase during hyperthyroidism.

Fusun Oztay; Bulent Ergin; Savas Ustunova; Huriye Balci; Aysegul Kapucu; Metin Caner; Cihan Demirci


Chinese Journal of Physiology | 2005

Effects of Orlistat and Its Relationship with Nitric Oxide in the Small Intestinal Mucosa

Metin Caner; Hüsniye Doğruman; Elif Tasktn; Aslt Kandil; Cihan Demirci


Biological Trace Element Research | 2007

Effects of artichoke extract supplementation on gonads of cadmium-treated rats

Ebru Gurel; Metin Caner; Levent Bayraktar; Nadim Yilmazer; Hüsniye Doğruman; Cihan Demirci


Cell Biochemistry and Function | 2007

Atorvastatin has cardiac safety at intensive cholesterol-reducing protocols for long term, yet its cancer-treatment doses with chemotherapy may cause cardiomyopathy even under coenzyme-Q10 protection.

Metin Caner; Bingür Sönmez; Ozlem Kurnaz; Caner Aldemir; Seda Salar; Tuncay Altug; Ayhan Bilir; Meric A. Altinoz


The Internet Journal of Internal Medicine | 2003

Diagnostic Value Of Transthoracic Needle Biopsy In 121 Cases With Peripheral Pulmonary Mass

Halil Yanarda; Metin Caner; Canan Akman; evki Meliko lu; Sedat Uygun; Sabriye Demirci; Tuncer Karayel

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