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Featured researches published by Mevhibe Tümüklü.


Bipolar Disorders | 2015

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia

Stefania Bonaccorso; Monsheel Sodhi; Jiang Li; William V. Bobo; Yuejin Chen; Mevhibe Tümüklü; Christos Theleritis; Karuna Jayathilake; Herbert Y. Meltzer

We tested the hypothesis that a common functional variant in brain‐derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic‐induced weight gain in bipolar disorder (BPD). Association of Val66Met with other metabolic measures, including high‐ and low‐density cholesterol, triglycerides, total cholesterol, fasting blood glucose, and hemoglobin A1c, was also tested.


Progress in Neuro-psychopharmacology & Biological Psychiatry | 2003

Effect of clozapine on serum leptin, insulin levels, and body weight and composition in patients with schizophrenia☆

Berna Binnur Kıvırcık; Köksal Alptekin; Sezer Caliskan; Abdurrahman Comlekci; Gonca Örük; Mevhibe Tümüklü; Kablan Kürklü; Haluk Arkar; Ayşe Türk; Mehmet Çalişkan; Sena Yesil

OBJECTIVE Weight gain frequently occurs during treatment with clozapine. However, the pathophysiology of clozapine-induced weight gain remains unclear. The aim of this study was to investigate the influence of clozapine on hormones leptin and insulin in relation to body weight and composition measures to determine their contribution to clozapine-induced weight gain. METHOD Data are reported on 19 patients with schizophrenia (11 women and 8 men) who completed 10 weeks of treatment with clozapine. Insulin levels, weight measurements, body mass index (BMI), and body composition measurements were evaluated at baseline and at the end of treatment. Leptin levels were assessed at baseline and after 4 and 10 weeks of treatment. Analysis of variance with repeated measures was used to evaluate changes in weight, body composition measures, leptin, and insulin. The Pearson correlations were used to assess the relationships between changes in hormone levels and weight along with body composition measurements. The correlations of change in Positive and Negative Syndrome Scale (PANSS) score with changes in hormone levels, weight gain and body composition measures were evaluated with Pearson correlations. RESULTS Leptin and insulin levels did not show any significant alterations across time. The use of clozapine was associated with significant increases in BMI (F=19.8, P<.001), lean muscle mass (F=8.2, P=.01), and fat mass (F=15.4, P=.001), while total body fluid percentage (F=4.1, P=.05) significantly decreased. Improvement in PANSS scores was not correlated to change in leptin, insulin, weight, BMI, or body composition measurements. The change in leptin levels was correlated to change in body fat mass. CONCLUSION The role of leptin in weight gain induced by clozapine might be a regulatory mechanism rather than being etiologic.


Psychiatry and Clinical Neurosciences | 2007

Panic symptoms in schizophrenia: Comorbidity and clinical correlates

Halis Ulas; Köksal Alptekin; Berna Binnur Akdede; Mevhibe Tümüklü; Yildiz Akvardar; Arzu Kitis; Selma Polat

Abstract  The aim of the present study was to investigate the prevalence of panic attack (PA) and panic disorder (PD) in patients with schizophrenia and detect the clinical features. Forty‐nine patients with schizophrenia were included in the study. Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HDRS), Clinical Global Impression (CGI), Extrapyramidal Symptom Rating Scale (ESRS) and Bandelow Panic and Agoraphobia Rating Scale were administered. Fifteen patients were found to have PA and seven patients had PD. Patients with panic symptoms had higher scores of PANSS, HDRS, CGI and ESRS. Comorbid panic symptoms in schizophrenia may be related to positive symptoms, extrapyramidal side‐effects and depression.


The Journal of Clinical Psychiatry | 2005

A double-blind controlled study of adjunctive treatment with risperidone in schizophrenic patients partially responsive to clozapine: efficacy and safety.

A. Elif Anıl Yağcıoğlu; Berna B. Kivircik Akdede; Tolga I. Turgut; Mevhibe Tümüklü; M. Kâzim Yazici; Köksal Alptekin; Aygun Ertugrul; Karu Jayathilake; Ahmet Göğüş; Zeliha Tunca; Herbert Y. Meltzer


The Journal of Clinical Psychiatry | 2006

A double-blind study of combination of clozapine with risperidone in patients with schizophrenia: effects on cognition.

Berna Binnur Akdede; A. Elif Anıl Yağcıoğlu; Köksal Alptekin; Tolga Turgut; Mevhibe Tümüklü; M. Kâzim Yazici; Karu Jayathilake; Zeliha Tunca; Ahmet Göğüş; Herbert Y. Meltzer


Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology | 2004

Substance use among patients with schizophrenia in a university hospital

Yildiz Akvardar; Mevhibe Tümüklü; Berna Binnur Akdede; Halis Ulas; Arzu Kitis; Köksal Alptekin


Social Psychiatry and Psychiatric Epidemiology | 2009

Prevalence and risk factors of psychotic symptoms: in the city of Izmir, Turkey.

Köksal Alptekin; Halis Ulas; Berna Binnur Akdede; Mevhibe Tümüklü; Yildiz Akvardar


Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology | 2008

Arrhythmic markers and clozapine in patients with schizophrenia: effect of 10 weeks clozapine treatment on heart rate variability, late potentials and QT dispersion -

Mevhibe Tümüklü; Köksal Alptekin; Önder Kirimli; Özgür Aslan; Berna Binnur Akdede; Özer Badak; Bahri Akdeniz; Özhan Göldeli; Sema Güneri


Schizophrenia Research | 2008

239 – White matter abnormalities in schizophrenia detected by diffusion tensor imaging

Mevhibe Tümüklü; Adam W. Anderson; L. Arlinghaus; Karuna Jayathilake; Herbert Y. Meltzer


Schizophrenia Research | 2008

NEIGHBOURHOOD VARIATION IN THE LIFETIME PREVALENCE OF PSYCHOTIC SYMPTOMS IN IZMIR, TURKEY

Tolga Binbay; Köksal Alptekin; Falko Biedermann; Semih Semin; Berna Binnur Akdede; Gül Ergör; Yildiz Akvardar; Yücel Demiral; Mevhibe Tümüklü; Arzu Kitis; Belgin Ünal

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Halis Ulas

Dokuz Eylül University

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Arzu Kitis

Dokuz Eylül University

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Ayşe Türk

Adnan Menderes University

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