Mi Ra Seong

Friedel-Crafts reaction of the Baylis-Hillman adducts of N-tosylimine derivatives

Friedel-Crafts reaction of aromatic compounds with the Baylis-Hillman adducts of N-tosylimine derivatives in the presence of sulfuric acid provided a stereoselective methodology for the preparation of 2-benzylsubstituted olefins in moderate yields.

Decarbonylative diarylation reaction of N-tosylated α-amino acids

Abstract The reaction of various N -tosylated α-amino acids with arenes in the presence of sulfuric acid afforded the corresponding diarylated derivatives in moderate yields, which were generated via decarbonylative arylation followed by Friedel-Crafts reaction of the generated tosylamide derivatives.

A Study on the Friedel-Crafts Type Reaction of Ninhydrin with Arenes

Abstract The reactions of ninhydrin (1, 1,2,3-indantrione) with arenes in the presence of concentrated sulfuric acid afforded mono- or di-substituted ninhydrin derivatives at the 2-position in reasonable yields.

Formation of Benzo[b]Indeno [2,1-d]Furanone Ring System During Alkylation of 2-(2-Hydroxyaryl)-2-Hydroxy-1,3-Indanedione Derivatives

Abstract During alkylation of 2-(2-hydroxyaryl)-2-hydroxy-1,3-indanedione derivatives, O-alkylated benzo[b]indeno[2,1-d]furanone derivatives were formed in appreciable amounts.

Formation of 2-arylnaphthalenes from N-tosylated phenylalanine derivatives

N-Tosylated phenylalanine derivatives in benzene in the presence of sulfuric acid afforded 2-arylnaphthalene derivatives in moderate yields. The reaction might proceed via the corresponding decarbonylated N-tosylimine derivatives. Aldol type reaction of N-tosylimines followed by intramolecular Friedel-Crafts reaction and elimination of p-toluenesulfonamide gave 2-arylnaphthalenes.

The Reaction of Ninhydrin with Trimethylbenzenes under Friedel-Crafts Reaction Conditions

Abstract The reaction of ninhydrin with 1,2,3- and 1,2,4-trimethylbenzene in the presence of H2SO4 or AlCl3 afforded 2-monoaryl and 2,2-diaryl-1,3-indanedione derivatives as the major products. With 1,3,5-trimethylbenzene as the arene nucleophile, either a reduction product or an indenoindanone derivative was obtained depending upon the catalyst employed in the reaction.

The Reaction of Ninhydrin with β-Acylpyruvates: Novel Spiro Compounds Formation

Abstract The reaction of β-acylpyruvates 2 with ninhydrin (1) and alloxan (5) afforded novel spiro tetrahydrofurandione derivatives 4 and 6 in excellent yields.

The Reaction of Organometallic Compounds with the Weinreb Amide of 3,7-Dichloroquinoline-8-carboxylic Acid

Abstract The reaction of Grignard or organolithium reagents with the Weinreb amide of 3,7-dichloroquinoline-8-carboxylic acid afforded 2-substituted derivatives 5 via nucleophilic substitution reaction with hydride transfer as the major product instead of the normally expected ketone derivatives 4.