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Featured researches published by Mian Ying Wang.


Chemistry Central Journal | 2009

Antioxidant activity of noni juice in heavy smokers

Mian Ying Wang; M. Nawal Lutfiyya; Vicki Weidenbacher-Hoper; Gary Anderson; Chen X. Su; Brett J. West

BackgroundNoni (Morinda citrifolia) juice has demonstrated antioxidant activity in vitro and in vivo. To evaluate this activity in humans, noni juice from Tahiti (TNJ) was evaluated in a 30 day, double-blind, and placebo controlled clinical trial with 285 current heavy smokers. Research participants were randomly assigned to three daily treatment groups: 118 mL placebo, 29.5 mL TNJ, and 118 mL TNJ. Plasma superoxide anion radicals (SAR) and lipid hydroperoxide (LOOH) levels were measured pre and post-intervention.ResultsAfter 30 days, mean SAR decreased from 0.26 ± 0.14 to 0.19 ± 0.10 μmol/mL in the 29.5 mL dose group (P < 0.01) and from 0.26 ± 0.22 to 0.18 ± 0.11 μmol/mL in the 118 mL dose group (P < 0.001). LOOH levels decreased from 0.53 ± 0.19 to 0.40 ± 0.10 μmol/mL in the 29.5 mL dose group (P < 0.001) and from 0.55 ± 0.21 to 0.40 ± 0.14 μmol/mL in the 118 mL dose group (P < 0.001). No significant reductions in SAR or LOOH levels were observed in the placebo group.ConclusionThe results suggest an antioxidant activity from noni juice in humans exposed to tobacco smoke, thereby replicating the results found previous chemical and in vivo tests.


Nutrition and Cancer | 2009

Morinda Citrifolia (Noni) Reduces Cancer Risk in Current Smokers by Decreasing Aromatic DNA Adducts

Mian Ying Wang; Lin Peng; May Nawal Lutfiyya; Eric Henley; Vicki Weidenbacher-Hoper; Gary Anderson

Quantitative determination of aromatic DNA adducts in peripheral blood lymphocytes (PBLs) of current smokers is an useful surrogate biomarker for the evaluation of environmental carcinogen exposure or chemopreventive intervention. In this study, we examined the impact of Tahitian Noni Juice (TNJ) on the aromatic DNA adducts of PBLs, before and after a 1-mo intervention, using 32P postlabeling assay. Of 283 enrolled, 203 smokers completed the trial. Aromatic DNA adducts levels in all participants were significantly reduced by 44.9% (P < 0.001) after drinking 1 to 4 oz of TNJ for 1 mo. Dose-dependent analyses of aromatic DNA adduct levels showed reductions of 49.7% (P < 0.001) in the 1-oz TNJ group and 37.6% (P < 0.001) in the 4-oz TNJ group. Gender-specific analyses resulted in no significant differences in the 4-oz TNJ groups. Interestingly, the 1-oz TNJ group showed a reduction of 43.1% (P < 0.001) in females compared with 56.1% (P < 0.001) in males. The results suggest that drinking 1 to 4 oz of TNJ daily may reduce the cancer risk in heavy cigarette smokers by blocking carcinogen-DNA binding or excising DNA adducts from genomic DNA.


The Scientific World Journal | 2012

Noni Juice Improves Serum Lipid Profiles and Other Risk Markers in Cigarette Smokers

Mian Ying Wang; Lin Peng; Vicki Weidenbacher-Hoper; Shixin Deng; Gary Anderson; Brett J. West

Cigarette smoke-induced oxidative stress leads to dyslipidemia and systemic inflammation. Morinda citrifolia (noni) fruit juice has been found previously to have a significant antioxidant activity. One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), high-sensitivity C-reactive protein (hs-CRP), and homocysteine. Volunteers drank noni juice or a fruit juice placebo daily for one month. Drinking 29.5 mL to 188 mL of noni juice per day significantly reduced cholesterol levels, triglycerides, and hs-CRP. Decreases in LDL and homocysteine, as well increases in HDL, were also observed among noni juice drinkers. The placebo, which was devoid of iridoid glycosides, did not significantly influence blood lipid profiles or hs-CRP. Noni juice was able to mitigate cigarette smoke-induced dyslipidemia, an activity associated with the presence of iridoids.


Antioxidants | 2017

Antioxidant Activity of Yichun Blue Honeysuckle (YBHS) Berry Counteracts CCl4-Induced Toxicity in Liver Injury Model of Mice

Mian Ying Wang; Madhuwanti Srinivasan; Subramanyam Dasari; Parnal Narvekar; Angela Lincy Prem Antony Samy; Venkata Satish Dontaraju; Lin Peng; Gary Anderson; Gnanasekar Munirathinam

Yichun Blue Honeysuckle (YBHS) is reported to have a broad range of health benefits including protection against a number of chronic diseases. The objective of our study was to determine whether YBHS exhibits antioxidant activity, and if so, determine how it provides protection against oxidative stress. Eight-week old mice (25 male and 25 female) were randomized into five groups (n = 10 per group). YBHS extract (at 6.25%, 12.5%, or 25%) was administrated via intra-gastric tube to mice at 0.1 mL/10 g body weight once daily for 7 days. On the 8th day, all animals except for the controls received 250 mg/kg of CCl4 through an intra-gastric tube. The animals were sacrificed 6 h after CCl4 administration. Liver samples obtained from these mice were analyzed for the levels of Thiobarbituric Acid Reactive Substances (TBARS) and glutathione and the activities of Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPx), using biochemical assay kits. Our results showed that YBHS indeed reduces lipid peroxidation, suggesting that YBHS decreases the Reactive Oxygen Species (ROS) levels. We also found that YBHS activated the endogenous antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase and its co-enzyme glutathione reductase. In addition, we showed that glutathione levels were increased by YBHS treatment. Furthermore, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay revealed that YBHS has potent free radical scavenging activity. Based on the results from our study, we conclude that YBHS scavenges ROS by enhancing the activity of the endogenous antioxidant defense system activity for conferring liver protective effects.


Plant Foods for Human Nutrition | 2008

Hepatic Protection by Noni Fruit Juice Against CCl4-Induced Chronic Liver Damage in Female SD Rats

Mian Ying Wang; Gary Anderson; Diane Nowicki; Jarakae Jensen


Plant Foods for Human Nutrition | 2008

Liver Protective Effects of Morinda citrifolia (Noni)

Mian Ying Wang; Diane Nowicki; Gary Anderson; Jarakae Jensen; Brett J. West


Archive | 2005

Profiles of lipid proteins and inhibiting HMG-CoA reductase

Afa Kehaati Palu; Claude Jarakae Jensen; Mian Ying Wang; Bing-Nan Zhou; Stephen P. Story


Archive | 2004

Selectively inhibiting estrogen production and providing estrogenic effects in the human body

Mian Ying Wang; Chen Xing Su; Afa Kehaati Palu; Bing-Nan Zhou; Brett J. West; Johannes Westendorf; Claude Jarakae Jensen; Stephen P. Story


Journal of Toxicological Sciences | 2011

A multigeneration reproductive and developmental safety evaluation of authentic Morinda citrifolia (noni) juice.

Mian Ying Wang; Jenae Hurn; Lin Peng; Diane Nowicki; Gary Anderson


Archive | 2005

IMPROVING PROFILES OF LIPID PROTEINS AND INHIBITING HMG-CoA REDUCTASE

Afa Kehaati Palu; Claude Jarakae Jensen; Mian Ying Wang; Bing-Nan Zhou; Stephen P. Story

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Gary Anderson

University of Illinois at Chicago

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Brett J. West

University of Illinois at Chicago

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Lin Peng

University of Illinois at Chicago

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Diane Nowicki

University of Illinois at Chicago

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Vicki Weidenbacher-Hoper

University of Illinois at Chicago

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Eric Henley

University of Illinois at Chicago

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Gnanasekar Munirathinam

University of Illinois at Chicago

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Madhuwanti Srinivasan

University of Illinois at Chicago

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May Nawal Lutfiyya

University of Illinois at Chicago

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