Michael A. Bender
United States Department of Energy
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Featured researches published by Michael A. Bender.
Mutation Research\/genetic Toxicology | 1988
Michael A. Bender; Robin C. Leonard; Jr. Otto White; Joseph P. Constantino; Carol K. Redmond
To test whether coke oven workers, an occupational group known to be at increased cancer risk, manifest increased peripheral blood chromosomal aberration frequencies, we obtained samples from a group of 30 steelworker volunteers, who had worked several years at coke oven jobs. Exposure estimates were made using measurements of work place atmospheric coal tar pitch volatiles and work histories. No statistically significant positive regression of chromosomal aberrations on exposure estimates was found. The data from the coke oven workers were also compared with the obtained concurrently and employing precisely the same laboratory protocol from a group of male Brookhaven National Laboratory employees. The coke oven workers as a group were found to have statistically significantly elevated frequencies of chromatid aberrations and of sister-chromatid exchanges.
Mutation Research Letters | 1992
Michael A. Bender; R.J. Preston; R.C. Leonard; B.E. Pyatt; P.C. Gooch
Sister-chromatid exchanges (SCE), phenomena of incompletely understood mechanism or significance, are often enumerated as a measure of genotoxicity, as their frequency is clearly elevated by exposure to many, if not most, chemical mutagens and carcinogens (Latt et al., 1984). However, SCE arise spontaneously, and in fairly large numbers per cell on average, in the absence of known genotoxin exposure. Statistical tests to determine whether SCE levels are elevated in a population or in an individual are based on underlying assumptions regard-
Radiation Research | 1987
Ruth C. Moore; Michael A. Bender
The effect of a 2-h post-treatment with aphidicolin at a dose sufficient to inhibit DNA synthesis on the yield of X-ray-induced chromosomal aberrations throughout the cell cycle was measured. Exposure to aphidicolin during and after irradiation brought about an increase in exchanges in cells irradiated in G2, in sister unions only in cells irradiated in S, and in all chromosome aberration types (fragments, sister unions, and dicentrics) in cells irradiated in G1. It is suggested that, during G1 and G2 but not during S inhibiting the repair enzyme alpha-polymerase brings about the conversion of some X-ray-induced DNA lesions to double-strand which can then take part in aberrations.
Mutation Research | 1988
Ruth C. Moore; Chris Randell; Michael A. Bender
Cultures of JU56 cells were irradiated with 2.5 Gy X-rays and 16 h later the cultures were exposed to a moderately inhibitory dose of 1-beta-D-arabinofuranosylcytosine (ara-C) or aphidicolin (APC) and to colcemid, for 2 h. The c-metaphases collected for examination had therefore been exposed to X-rays in G1 or early S, and to the repair inhibitors APC and ara-C during the latter half of G2. It was found that treatment of cells irradiated early in cell cycle, that is, in G1 and early S, with APC or ara-C in G2, (1) reduced the frequency of chromatid and chromosome exchanges below that of cells treated with X-rays alone, (2) produced no more chromatid breaks and gaps than were seen in unirradiated cells, (3) increased the number of chromosome fragments and gaps in a more than additive fashion, and (4) produced only an additive effect, by comparison with the effect of X-rays and drug given separately, on the total number of chromosomal aberrations.
Mutation Research\/genetic Toxicology | 1988
Michael A. Bender; R.Julian Preston; Robin C. Leonard; B.E. Pyatt; P.Carolyn Gooch; Michael D. Shelby
Mutation Research | 1989
Michael A. Bender; R.Julian Preston; Robin C. Leonard; B.E. Pyatt; P.Carolyn Gooch
Cancer Research | 1988
Michael A. Bender; Michael V. Viola; John Fiore; Margaret H. Thompson; Robin C. Leonard
Cancer Research | 1990
Sadayuki Ban; Richard B. Setlow; Michael A. Bender; Haruo Ezaki; Toshio Hiraoka; Motoi Yamane; Masayuki Nishiki; Kiyohiko Dohi; Akio A. Awa; Richard C. Miller; Dilys M. Parry; John J. Mulvihill; Gilbert W. Beebe
Mutation Research Letters | 1990
Michael A. Bender; R.J. Preston; R.C. Leonard; B.E. Pyatt; P.C. Gooch
Archive | 1988
Avril D. Woodhead; Michael A. Bender; Robin C. Leonard