Michael A. Witt

Varicocele: A progressive or static lesion?

Varicoceles are associated with ipsilateral testicular atrophy in the adolescent. To determine if varicoceles are capable of causing progressive loss of fertility, we conducted a date-matched, retrospective study. We reviewed 2,989 patients evaluated for infertility at our institution from 1985 to 1990. A total of 285 (8.5%) patients were diagnosed with secondary infertility. A varicocele was identified as the cause of the patients infertility in 177 (69%) men with secondary infertility. When matched by date to an identical number of men with primary infertility in whom 128 (50%) were infertile on the basis of a varicocele effect, the difference was significant (p < 0.0001). We conclude that a varicocele in some men is a progressive and not a static lesion resulting in the loss of previously established fertility. In addition, varicoceles are not only the leading cause of infertility in men with secondary infertility, but also occur with a greater frequency than in men with primary infertility.

THE CORRELATION OF INTERNAL SPERMATIC VEIN PALPABILITY WITH ULTRASONOGRAPHIC DIAMETER AND REVERSAL OF VENOUS FLOW

A gold standard that defines the presence of a subclinical varicocele does not exist. No one has accurately demonstrated at what diameter an internal spermatic vein becomes palpable. We correlated the clinical examination of the scrotum with ultrasonographic measurements of internal spermatic vein diameter and reversal of venous flow in 156 testicles. The internal spermatic vein became palpable at diameters of 3.0 to 3.5 mm. Reversal of flow was found in all veins larger than 3.5 mm. and did not occur in any veins smaller than 2.5 mm. In veins with diameters of 2.5 to 3.5 mm. neither palpability nor internal spermatic vein diameter correlated with the reversal of flow by duplex Doppler color ultrasound. If the internal spermatic vein is nonpalpable during the diagnostic evaluation of the infertile man we do not advocate further radiographic studies. If the palpability of the internal spermatic vein is questionable duplex Doppler color ultrasound is indicated.

The Correlation of Cavernous Systolic Occlusion Pressure With Peak Velocity Flow Using Color Duplex Doppler Ultrasound

This prospective study involved 27 patients who underwent dynamic infusion cavernosometry/cavernosography and color duplex Doppler ultrasound. Phase III dynamic infusion cavernosometry/cavernosography determination of cavernous artery systolic occlusion pressure and color duplex Doppler measurements of peak velocity flow were performed. Four subpopulations were defined: 1) normal cavernous artery systolic occlusion pressure and peak velocity flow, 2) abnormal systolic occlusion pressure and normal peak velocity flow, 3) normal systolic occlusion pressure and abnormal peak velocity flow, and 4) abnormal systolic occlusion pressure and peak velocity flow. Peak velocity flow significantly correlated with cavernous artery systolic occlusion pressure and, using a normal value of greater than 25 cm. per second, resulted in a sensitivity and specificity of 95%. The positive predictive value of an abnormal peak velocity flow was calculated to be 95%. We conclude that peak velocity flow is an effective, reliable and noninvasive means of evaluating corporeal arterial function in an office setting.

A closed system for corporeal irrigation in the treatment of refractory priapism

The treatment of priapism, although considered a urologic emergency, has been historically diverse and often unsuccessful. We propose a method of corporeal aspiration and irrigation in an entirely closed system for priapism refractory to conservative measures. The advantages of this system are a reduced risk of body fluid exposure and corporeal contamination and the capacity for extended irrigation without repeated corporeal puncture.