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Dive into the research topics where Michael C. Little is active.

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Featured researches published by Michael C. Little.


Archive | 1992

Enhanced Signal Generation by Target Amplification

Rüdiger Rüger; David Segev; Michael C. Little; James G. Nadeau; G. Terrance Walker; James L. Schram; Melinda S. Fraiser; Amy Alexander; Douglas P. Malinowski; George H. Shimer; Keith C. Backman; E. James; Erko Stackebrandt; Werner Liesack

The polymerase chain reaction (PCR) represents the most common and widespread method for the direct amplification of specific sequences of nucleic acid target molecules. The basic reaction is comprised of three steps: 1. Denaturation of the target DNA 2. Annealing of sequence specific primers 3. Template-specific elongation of these primers with a DNA polymerase and desoxynucleotides


Archive | 1995

Strand displacement amplification using thermophilic enzymes

Melinda S. Fraiser; Catherine A. Spargo; George Terrance Walker; Mark Van Cleve; David James Wright; Michael C. Little


Archive | 1991

Nucleic acid target generation

George Terrance Walker; Michael C. Little; James G. Nadeau


Archive | 1993

Simultaneous amplification of multiple targets

George Terrance Walker; James G. Nadeau; Michael C. Little


Clinical Chemistry | 1999

Strand Displacement Amplification and Homogeneous Real-Time Detection Incorporated in a Second-Generation DNA Probe System, BDProbeTecET

Michael C. Little; Jeffrey P. Andrews; Richard H. Moore; Silvia A. Bustos; Lynda Jones; Chris Embres; Gerard P Durmowicz; James M. Harris; Dolores M. Berger; Karen Yanson; Christine Ann Rostkowski; Daretta A. Yursis; James Arthur Price; Thomas L. Fort; Adriann Howard Walters; Matthew P. Collis; Oscar J. Llorin; Janet Wood; Frank L. Failing; Christian O’Keefe; Brian G. Scrivens; Bill Pope; Timothy Hansen; Ken Marino; Keith Williams; Michael Boenisch


Archive | 1997

Kit and method for fluorescence based detection assay

Michael C. Little; Glenn P. Vonk


Archive | 1994

Internal controls for isothermal nucleic acid amplification reactions

James G. Nadeau; Michael C. Little


Archive | 1995

Mycobacteriophage specific for the mycobacterium tuberculosis complex

Robert E. Pearson; Julie A. Dickson; Paul T. Hamilton; Michael C. Little; Wayne F. Beyer


Archive | 1995

Identification of mycobacterium tuberculosis complex species

Stewart Jurgensen; Michael C. Little; Paul T. Hamilton; Paul Riska; John Chan; Barry R. Bloom


Archive | 1998

Method for reducing inhibitors of nucleic acid hybridization

Matthew P. Collis; Michael C. Little; Oscar J. Llorin

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