Michael Charles Nyman
Exelixis
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Publication
Featured researches published by Michael Charles Nyman.
Bioorganic & Medicinal Chemistry Letters | 2015
Ellen K. Kick; Richard Martin; Yinong Xie; Brenton T. Flatt; Edwin Schweiger; Tie-Lin Wang; Brett B. Busch; Michael Charles Nyman; Xiao-Hui Gu; Grace Yan; Brandee L. Wagner; Max Nanao; Lam Nguyen; Thomas J. Stout; Artur Plonowski; Ira G. Schulman; Jacek Ostrowski; Todd G. Kirchgessner; Ruth R. Wexler; Raju Mohan
A series of biaryl pyrazole and imidazole Liver X Receptor (LXR) partial agonists has been synthesized displaying LXRβ selectivity. The LXRβ selective partial agonist 18 was identified with potent induction of ATP binding transporters ABCA1 and ABCG1 in human whole blood (EC50=1.2μM, 55% efficacy). In mice 18 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist.
Archive | 2002
Lynne Canne Bannen; Jeff Chen; Lisa Esther Dalrymple; Brenton T. Flatt; Timothy Patrick Forsyth; Xiao-Hui Gu; Morrison B. Mac; Larry W. Mann; Grace Mann; Richard Martin; Raju Mohan; Brett Murphy; Michael Charles Nyman; William C. Stevens; Tie-Lin Wang; Yong Wang; Jason H. Wu
Archive | 2006
Brett B. Busch; Brenton T. Flatt; Xiao-Hui Gu; Shao-Po Lu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens; Tie-Lin Wang; Yinong Xie
Archive | 2006
Brenton T. Flatt; Xiao-Hui Gu; Richard Martin; Raju Mohan; Brett Murphy; Michael Charles Nyman; William C. Stevens; Tie-Lin Wang
Archive | 2006
Brett B. Busch; Brenton T. Flatt; Xiao-Hui Gu; Shao Po Lu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens; Tie-Lin Wang; Yinong Xie
Archive | 2005
Christopher D. Bayne; Alan T. Johnson; Shao-Po Lu; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens; Haixia Wang; Yinong Xie; Lynne Canne Bannen; Diva Sze-Ming Chan; Ping Huang; Vasu Jammalamadaka; Richard George Khoury; Morrison B. Mac; Jason Jevious Parks; Yong Wang; Wei Xu
ACS Medicinal Chemistry Letters | 2016
Ellen K. Kick; Brett B. Busch; Richard J. Martin; William C. Stevens; Venkataiah Bollu; Yinong Xie; Brant Clayton Boren; Michael Charles Nyman; Max Nanao; Lam Nguyen; Artur Plonowski; Ira G. Schulman; Grace Yan; Huiping Zhang; Xiaoping Hou; Meriah Neissel Valente; Rangaraj Narayanan; Kamelia Behnia; A. David Rodrigues; Barry Brock; James Smalley; Glenn H. Cantor; John A. Lupisella; Paul G. Sleph; Denise Grimm; Jacek Ostrowski; Ruth R. Wexler; Todd G. Kirchgessner; Raju Mohan
Archive | 2006
Breet B. Busch; Brenton T. Flatt; Xiao Hui Gu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens; Tie Lin Wang; Yinong Xie; Shao-Po Lu
Archive | 2006
Brett B. Busch; Brenton T. Flatt; Xiao-Hui Gu; Shao-Po Lu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens; Tie-Lin Wang; Yinong Xie
Archive | 2006
Breet B. Busch; Brenton T. Flatt; Xiao Hui Gu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens; Tie Lin Wang; Yinong Xie; Shao-Po Lu
