Michael D. Varney | Researchain

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Featured researches published by Michael D. Varney.

Journal of Medicinal Chemistry | 1994

Application of the Three-Dimensional Structures of Protein Target Molecules in Structure-Based Drug Design

Jonathan Greer; John W. Erickson; John J. Baldwin; Michael D. Varney

Archive | 2001

Amide compounds for inhibiting protein kinases

Steven Lee Bender; Dilip Bhumralkar; Michael Raymond Collins; Stephan James Cripps; Judith Gail Deal; Mitchell David Nambu; Cynthia Louise Palmer; Zhengwei Peng; Michael D. Varney; Lei Jia

Journal of Medicinal Chemistry | 1996

Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase

Terence R. Jones; Michael D. Varney; Stephen E. Webber; Kathleen K. Lewis; Gifford P. Marzoni; Cindy L. Palmer; Vinit Kathardekar; Katharine M. Welsh; Stephanie Webber; David A. Matthews; Krzysztof Appelt; Ward W. Smith; Janson Ca; Jesus Ernesto Villafranca; Russell J. Bacquet; Eleanor F. Howland; Carol L. J. Booth; Steven M. Herrmann; Robert W. Ward; Jennifer White; Ellen W. Moomaw; and Charlotte A. Bartlett; Cathy A. Morse

Archive | 1995

Compounds useful as antiproliferative agents and GARFT inhibitors

Michael D. Varney; William H. Romines

Journal of Medicinal Chemistry | 1996

An approach to rapid estimation of relative binding affinities of enzyme inhibitors : application to peptidomimetic inhibitors of the human immunodeficiency virus type 1 protease

Vellarkad N. Viswanadhan; M. Rami Reddy; Alexander Wlodawer; Michael D. Varney; John N. Weinstein

Journal of Medicinal Chemistry | 1997

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition

Michael D. Varney; Cindy L. Palmer; William H. Romines; Theodore J. Boritzki; Stephen Margosiak; Robert J. Almassy; Cheryl A. Janson; Charlotte A. Bartlett; Eleanor J. Howland; Rosanne Ferre

Journal of Medicinal Chemistry | 1995

Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.

Michael D. Varney; Cindy L. Palmer; Judith Gail Deal; Stephanie Webber; Katherine M. Welsh; Charlotte A. Bartlett; Catharine A. Morse; Ward W. Smith; Cheryl A. Janson

Journal of Medicinal Chemistry | 1997

Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase

Terence R. Jones; Stephen E. Webber; Michael D. Varney; M. Rami Reddy; Kathleen K. Lewis; Vinit Kathardekar; Hormoz Mazdiyasni; Judith Gail Deal; Dzuy T. Nguyen; Katharine M. Welsh; Stephanie Webber; Amanda L. Johnston; David A. Matthews; Ward W. Smith; Cheryl A. Janson; Russell J. Bacquet; Eleanor F. Howland; Carol L. J. Booth; Steven M. Herrmann; Robert W. Ward; Jennifer White; Charlotte A. Bartlett; Cathy A. Morse

Journal of Medicinal Chemistry | 1994