Michael Humora
Bristol-Myers Squibb
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Publication
Featured researches published by Michael Humora.
Tetrahedron | 2000
Stan V. D'Andrea; D P Bonner; Joanne J. Bronson; Junius M. Clark; Ken L. DenBleyker; Joan Fung-Tomc; Shelley E. Hoeft; Thomas W. Hudyma; John D. Matiskella; Raymond F. Miller; Peter F. Misco; Michael J. Pucci; Roman Z. Sterzycki; Yuan Tsai; Yasutsuga Ueda; John A. Wichtowski; Janak Singh; Thomas P. Kissick; Jeffery T. North; Annie Pullockaran; Michael Humora; Brenda T Boyhan; Truc Chi Vu; Alan Fritz; J. Heikes; Rita Fox; Jollie D. Godfrey; Robert Kevin Perrone; Murray Arthur Kaplan; David R. Kronenthal
Abstract Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were 2,5-dichlorophenylthioacetamido and 2,6-dichloropyrid-4-ylthioacetamido. The C-3 thiopyridinium rings were substituted at nitrogen with amino acid and pyruvic acid groups that were designed to confer aqueous solubility as required for IV formulation. This paper describes the characteristics of these novel cephalosporins and highlights synthetic methods developed to allow their practical, large-scale syntheses.
Tetrahedron-asymmetry | 1998
Bang-Chi Chen; Sandra L. Quinlan; J. Gregory Reid; Paul A. Jass; Tonya P Robinson; William Early; Edward J. Delaney; Michael Humora; Gary D. Madding; John J. Venit; William J. Winter
Abstract BMS-180448, (3S,4R)- 2 , was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with the potassium dianion of cyanoguanidine 11 .
Organic Process Research & Development | 2002
Zhongmin Xu; Janak Singh; Mark D. Schwinden; Bin Zheng; Thomas P. Kissick; Bharat P. Patel; Michael Humora; Fernando Quiroz; Lin Dong; ‡ Dau-Ming Hsieh; James E. Heikes; Madhusudhan Pudipeddi; Mark D. Lindrud; Sushil K. Srivastava; David R. Kronenthal; Richard H. Mueller
Archive | 2000
Guixue Yu; John E. Macor; Soojin Kim; Hyei-Jha Chung; Michael Humora; Kishta Katipally; Yizhe Wang
Organic Letters | 2003
Janak Singh; David R. Kronenthal; Mark D. Schwinden; Jollie D. Godfrey; Rita Fox; Edward J. Vawter; Bo Zhang; Thomas P. Kissick; Bharat P. Patel; Omar Mneimne; Michael Humora; Chris G. Papaioannou; Walter Szymanski; Michael K. Y. Wong; Chien K. Chen; James E. Heikes; John D. Dimarco; Jun Qiu; Rajendra P. Deshpande; Jack Z. Gougoutas; Richard H. Mueller
Organic Process Research & Development | 1997
Richard H. Mueller; Shaopeng Wang; Paul D. Pansegrau; Joy Q. Jannotti; Michael A. Poss; John K. Thottathil; Janak Singh; Michael Humora; and Thomas P. Kissick; Brenda T Boyhan
Organic Process Research & Development | 2002
Frank Gibson; Ambarish K. Singh; Maxime Soumeillant; Percy S. Manchand; Michael Humora; David R. Kronenthal
Organic Process Research & Development | 2012
John Guzowski; Edward J. Delaney; Michael Humora; Erwin Irdam; William F. Kiesman; Albert Kwok; Amy D. Moran
Organic Process Research & Development | 2000
Janak Singh; Oak K. Kim; Thomas P. Kissick; Kenneth J. Natalie; Bo Zhang; Gerard Crispino; Dane M. Springer; John A. Wichtowski; Yunhui Zhang; Jason Goodrich; Yasutsugu Ueda; Bing Y. Luh; Brian D. Burke; Matthew Brown; Anthony P. Dutka; Bin Zheng; ‡ Dau-Ming Hsieh; Michael Humora; Jeffrey T. North; Anne J. Pullockaran; Juliya Livshits; Shankar Swaminathan; Zhinong Gao; Peter Schierling; Peter H. Ermann; Robert Kevin Perrone; Mei C. Lai; Jack Z. Gougoutas; John D. Dimarco; Joanne J. Bronson
Archive | 2012
Weirong Chen; Michael Humora; Daw-Long Albert Kwok; William F. Kiesman; Erwin Irdam
