Michael J. Hadd
Ambit Biosciences
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Publication
Featured researches published by Michael J. Hadd.
Bioorganic & Medicinal Chemistry Letters | 2011
Sunny Abraham; Michael J. Hadd; Lan Tran; Troy Vickers; Janice Sindac; Zdravko V. Milanov; Mark W. Holladay; Shripad S. Bhagwat; Helen Hua; Julia M. Ford Pulido; Merryl D. Cramer; Dana Gitnick; Joyce James; Alan Dao; Barbara Belli; Robert C. Armstrong; Daniel Kelly Treiber; Gang Liu
The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.
Archive | 2012
Michael J. Hadd; Michael D. Hocker; Mark W. Holladay; Gang Liu; Martin W. Rowbottom; Shimin Xu
Archive | 2010
Sunny Abraham; Qi Chao; Michael J. Hadd; Mark W. Holladay; Gang Liu; Eduardo Setti
Archive | 2011
Michael J. Hadd; Mark W. Holladay; Martin W. Rowbottom
Archive | 2011
Raffaella Faraoni; Michael J. Hadd; Mark W. Holladay; Martin W. Rowbottom; Eduardo Setti
Archive | 2011
Qi Chao; Michael J. Hadd; Mark W. Holladay; Martin W. Rowbottom
Archive | 2011
Michael J. Hadd
Archive | 2011
Michael J. Hadd; Mark W. Holladay; Martin W. Rowbottom
Archive | 2011
Michael J. Hadd
Archive | 2011
Michael J. Hadd; Mark W. Holladay; Eduardo Setti
