Michael Nadson Santos Santana
Universidade Federal de Sergipe
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Featured researches published by Michael Nadson Santos Santana.
Frontiers in Physiology | 2016
Fabricio Macedo; Thássio Ricardo Ribeiro Mesquita; V.U. Melo; Marcelo Mendonça Mota; Tharciano Luiz Teixeira Braga da Silva; Michael Nadson Santos Santana; Larissa Resende Oliveira; Robervan Vidal Santos; Rodrigo Miguel dos Santos; Sandra Lauton-Santos; Márcio R. V. Santos; André Sales Barreto; Valter J. Santana-Filho
Resistance training is one of the most common kind of exercise used nowadays. Long-term high-intensity resistance training are associated with deleterious effects on vascular adjustments. On the other hand, is unclear whether low-intensity resistance training (LI-RT) is able to induce systemic changes in vascular tone. Thus, we aimed to evaluate the effects of chronic LI-RT on endothelial nitric oxide (NO) bioavailability of mesenteric artery and cardiovascular autonomic modulation in healthy rats. Wistar animals were divided into two groups: exercised (Ex) and sedentary (SED) rats submitted to the resistance (40% of 1RM) or fictitious training for 8 weeks, respectively. After LI-RT, hemodynamic measurements and cardiovascular autonomic modulation by spectral analysis were evaluated. Vascular reactivity, NO production and protein expression of endothelial and neuronal nitric oxide synthase isoforms (eNOS and nNOS, respectively) were evaluated in mesenteric artery. In addition, cardiac superoxide anion production and ventricle morphological changes were also assessed. In vivo measurements revealed a reduction in mean arterial pressure and heart rate after 8 weeks of LI-RT. In vitro studies showed an increased acetylcholine (ACh)-induced vasorelaxation and greater NOS dependence in Ex than SED rats. Hence, decreased phenylephrine-induced vasoconstriction was found in Ex rats. Accordingly, LI-RT increased the NO bioavailability under basal and ACh stimulation conditions, associated with upregulation of eNOS and nNOS protein expression in mesenteric artery. Regarding autonomic control, LI-RT increased spontaneous baroreflex sensitivity, which was associated to reduction in both, cardiac and vascular sympathetic modulation. No changes in cardiac superoxide anion or left ventricle morphometric parameters after LI-RT were observed. In summary, these results suggest that RT promotes beneficial vascular adjustments favoring augmented endothelial NO bioavailability and reduction of sympathetic vascular modulation, without evidence of cardiac overload.
Journal of Developmental Origins of Health and Disease | 2017
R. Vidal-Santos; Fernanda Macedo; Michael Nadson Santos Santana; V. U. De Melo; J. L. de Brito Alves; Márcio R. V. Santos; Luciana C. Brito; E. Nascimento; João Henrique Costa-Silva; Valter J. Santana-Filho
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mothers diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram. Cardiovascular parameters were measured on the same period. Autonomic nervous system modulation was evaluated by spectrum analysis of heart rate (HR) and systolic arterial pressure (SAP). The W increased glycemia (123±2 v. 155±2 mg/dl), low-density lipoprotein (15±1 v. 31±2 mg/dl), triglycerides (49±1 v. 85±2 mg/dl), total cholesterol (75±2 v. 86±2 mg/dl), and decreased high-density lipoprotein (50±4 v. 38±3 mg/dl), as well as increased body mass (209±4 v. 229±6 g) than C. Furthermore, the W showed higher SAP (130±4 v. 157±2 mmHg), HR (357±10 v. 428±14 bpm), sympathetic modulation to vessels (2.3±0.56 v. 6±0.84 mmHg2) and LF/HF ratio (0.15±0.01 v. 0.7±0.2) than C. These findings suggest that a western diet during pregnancy and lactation leads to overweight associated with autonomic misbalance and hypertension in adulthood.
Journal of Molecular and Cellular Cardiology | 2018
Michael Nadson Santos Santana; Diego Santos Souza; Rodrigo Miguel-dos-Santos; Thallita Kelly Rabelo; Carla Maria Lins de Vasconcelos; Juliana Maria Navia-Pelaez; Itamar Couto Guedes de Jesus; Júlio Alves da Silva-Neto; Sandra Lauton-Santos; Luciano S. A. Capettini; Silvia Guatimosim; Russell G. Rogers; Márcio R. V. Santos; Valter J. Santana-Filho; Thássio Ricardo Ribeiro Mesquita
BACKGROUND Currently viewed as a complementary non-pharmacological intervention for preventing cardiac disorders, long-term aerobic training produces cardioprotection through remote ischemic preconditioning (RIPC) mechanisms. However, RIPC triggered by acute exercise remains poorly understood. Although resistance exercise (RE) has been highly recommended by several public health guidelines, there is no evidence showing that RE mediates RIPC. Hence, we investigated whether RE induces cardiac RIPC through nitric oxide synthase (NOS)-dependent mechanism. METHODS AND RESULTS Acute RE at 40% of the maximal load augmented systemic nitrite levels, associated with increased cardiac eNOS phosphorylation, without affecting nNOS activity. Using an experimental model of myocardial infarction (MI) through ischemia-reperfusion (IR), RE fully prevented the loss of cardiac contractility and the extent of MI size compared to non-exercised (NE) rats. Moreover, RE mitigated aberrant ST-segment and reduced life-threatening arrhythmias induced by IR. Importantly, inhibition of NOS abolished the RE-mediated cardioprotection. After IR, NE rats showed increased cardiac eNOS activity, associated with reduced dimer/monomer ratio. Supporting the pivotal role of eNOS coupling during MI, non-exercised rats displayed a marked generation of reactive oxygen species (ROS) and oxidative-induced carbonylation of proteins, whereas RE prevented these responses. We validated our data demonstrating a restoration of physiological ROS levels in NE + IR cardiac sections treated with BH4, a cofactor oxidatively depleted during eNOS uncoupling, while cardiac ROS generation from exercised rats remained unchanged, suggesting no physiological needs of supplemental eNOS cofactors. CONCLUSION Together, our findings strongly indicate that RE mediates RIPC by limiting eNOS uncoupling and mitigates myocardial IR injury.
The FASEB Journal | 2015
Fabricio Macedo; Thássio Ricardo Ribeiro Mesquita; Vitor Ulisses de Melo; Rodrigo Miguel dos Santos; Michael Nadson Santos Santana; Robervan Santos; Larissa Resende Oliveira; Marcelo Mendonça Mota; Tharciano Luiz Teixeira Braga da Silva; André Sales Barreto; Márcio R. V. Santos; Sandra Lauton-Santos; Valter J. Santana-Filho
The FASEB Journal | 2015
Elizabete Silva-Filha; Tamires Costa; Bruna Farias; Polyana Santos; Michael Nadson Santos Santana; Fabricio Macedo; Robervan Santos; Valter J. Santana-Filho
Autonomic Neuroscience: Basic and Clinical | 2015
Valter J. Santana-Filho; V.U. Melo; Rayssa Rizerio de Moura Saldanha; Fabricio Macedo; Michael Nadson Santos Santana; Larissa Resende Oliveira; Robervan Vidal Santos; André Sales Barreto; Márcio R. V. Santos; J. C. Cruz; Santos Cr; Lisete C. Michelini
The FASEB Journal | 2014
Larissa Resende Oliveira; Fabricio Macedo; Vitor Ulisses de Melo; Marcelo Mendonça Mota; Tharciano Luiz Teixeira Braga da Silva; Milene Tavares Fontes; Michael Nadson Santos Santana; Robervan Santos; André Sales Barreto; Márcio Roberto dos Santos; Valter J. Santana-Filho
The FASEB Journal | 2013
Mario Matiotti Neto; Robervan Vidal Santos; V.U. Melo; Fabricio Macedo; Jose Luiz de Brito Alves; Márcio R. V. Santos; Larissa Resende Oliveira; Michael Nadson Santos Santana; Luciana C. Brito; João Silva; Elizabeth Nasciment; Pauliana Ribeiro dos Santos
The FASEB Journal | 2013
Robervan Santos; Vitor Melo; Fabricio Macedo; Jose Luiz de Brito Alves; Márcio R. V. Santos; Larissa Resende Oliveira; Michael Nadson Santos Santana; Mario Matiotti; Luciana C. Brito; Elizabeth Nascimento; João Silva; Valter J. Santana-Filho
The FASEB Journal | 2012
Michael Nadson Santos Santana; Leonardo Yung dos Santos Maciel; Kamilla Mayara Lucas da Cruz; Ariane Martins de Araujo; Hugo Caxico de Amorim