Michael Puhl

Peter Schäfer; Gerhard Hamprecht; Michael Puhl; Karl-Otto Westphalen; Cyrill Zagar

Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. Besides open-chain phenylpyridines also anellated compounds, such as pyridine-substituted 2H-1,4-benzothiazin-3(4H)-one or 3,4-dihydro-1H-quinolin-2-one, were prepared. Phenylpyridines act by inhibition of protoporphyrinogen-IX-oxidase. Their synthesis will be described in conjunction with structure-activity relationships. Phenylpyridines are highly active against many important broadleaf and grass weed species under pre- and - in particular - post-emergent conditions.

Michael Puhl; Andreas Gypser; Gerhard Hamprecht; Thorsten Volk; Peter Schäfer; Robert Reinhard; Ingo Sagasser; Cyrill Zagar; Matthias Witschel; Andreas Landes

Gerhard Hamprecht; Michael Puhl; Olaf Menke; Robert Reinhard; Ingo Sagasser; Cyrill Zagar

Michael Puhl; Thorsten Volk; Gerhard Hamprecht; Robert Reinhard; Ingo Sagasser; Cyrill Zagar; Matthias Witschel; Helmut Walter

Cyrill Zagar; Robert Reinhard; Michael Puhl; Thorsten Volk; Norbert Goetz; Gerhard Hamprecht; Olaf Menke; Ingo Sagasser

Gerhard Hamprecht; Olaf Menke; Robert Reinhard; Michael Puhl; Ingo Sagasser; Cyrill Zagar; Matthias Witschel; Helmut Walter

Olaf Menke; Robert Reinhard; Gerhard Hamprecht; Michael Puhl; Ingo Sagasser; Cyrill Zagar; Martina Otten; Karl-Otto Westphalen; Helmut Walter

Gerhard Hamprecht; Michael Puhl; Robert Reinhard; Ingo Sagasser; Cyrill Zagar; Karl-Otto Westphalen; Matthias Witschel; Helmut Walter

Gerhard Hamprecht; Michael Puhl; Robert Reinhard; Ingo Sagasser; Cyrill Zagar; Karl-Otto Westphalen; Matthias Witschel; Helmut Walter

Gerhard Hamprecht; Olaf Menke; Michael Puhl; Robert Reinhard; Ingo Sagasser; Cyrill Zagar