Michael R. Hayden
Johns Hopkins University School of Medicine
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Featured researches published by Michael R. Hayden.
Genomics | 1987
Marcy E. MacDonald; Mary Anne Anderson; T. Conrad Gilliam; Lisbeth Tranebjaerg; Nancy J. Carpenter; Ellen Magenis; Michael R. Hayden; Steven T. Healey; Tom I. Bonner; James F. Gusella
Thirty-four random DNA probes from the terminal half of the human chromosome 4 short arm were further localized within 4pter----p15.1. A panel of somatic cell hybrid lines defining six chromosomal regions within 4pter----p15.1 was constructed using human cell lines containing translocation or deletion chromosomes. The vast majority of the DNA sequences, 32 of 34 or 94%, mapped to the three most proximal regions comprising 4p16.1----4p15.1. Only two probes were localized distal to 4p16.1: one in the region 4p16.3----4p16.1 and one in 4p16.3. D4S10, a polymorphic DNA marker linked to the Huntingtons disease defect, has previously been mapped to the terminal region of 4p with conflicting assignments to 4p16.1 and 4p16.3. Analysis of restriction fragment length polymorphisms demonstrated hemizygosity for D4S10 in a patient with Wolf-Hirschhorn syndrome resulting from an unbalanced translocation t(4;8)(p16.3;p23.1), supporting the 4p16.3 localization. Our panel of somatic cell hybrids provides a rapid method for mapping new probes to the same vicinity as that of D4S10. However, the relative paucity of such DNA segments identified here suggests that a more directed approach may be required to generate additional markers near the HD gene.
Science | 2001
Chiara Zuccato; Andrea Ciammola; Dorotea Rigamonti; Blair R. Leavitt; Donato Goffredo; Luciano Conti; Marcy E. MacDonald; Robert M. Friedlander; Vincenzo Silani; Michael R. Hayden; Tõnis Timmusk; Simonetta Sipione
Journal of Biological Chemistry | 2000
Cheryl L. Wellington; Roshni R. Singaraja; Lisa M. Ellerby; Jane Savill; Sophie Roy; Blair R. Leavitt; Abigail S. Hackam; Alan H. Sharp; Nancy Thornberry; Donald W. Nicholson; Dale E. Bredesen; Michael R. Hayden
Journal of Biological Chemistry | 2003
Frederick C. Nucifora; Lisa M. Ellerby; Cheryl L. Wellington; Jon D. Wood; William J. Herring; Akira Sawa; Michael R. Hayden; Valina L. Dawson; Ted M. Dawson; Christopher A. Ross
Archive | 2001
Michael R. Hayden; Abigail S. Hackam; Blair R. Leavitt
Archive | 2015
Asad Jan; Joanna M. Karasinska; Martin H. Kang; Willeke de Haan; Piers Ruddle; Achint Kaur; Colum Connolly; Blair R. Leavitt; Poul H. Sorensen; Michael R. Hayden
Archive | 2010
Susan S. Smyth; Yury J. Sigal; Zehra Pamuklar; Yong P. Xu; Glenn D. Prestwich; Andrew J. Morris; Horng-Yuan Kan; Michael R. Hayden; Roshni R. Singaraja; Lin-Hua Zhang; Vassilis I. Zannis; Dimitris Kardassis
Archive | 2010
Soonkyu Chung; Jenelle M. Timmins; MyNgan Duong; Chiara Degirolamo; Shunxing Rong; Janet K. Sawyer; Roshni R. Singaraja; Michael R. Hayden; Nobuyo Maeda; Lawrence L. Rudel; Gregory S. Shelness; John S. Parks
Archive | 2009
Michael Conneally; D Craufurd; Michael R. Hayden; Bernhard Landwehrmeyer; Ira Shoulson; Blair R. Leavitt; Elizabeth McCusker
Archive | 2004
Michael R. Hayden; Abigail S. Hackam; Blair R. Leavitt; Edmond Chan