Michael Roguska
Novartis
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Michael Roguska.
Nature Communications | 2017
Joy Ghosh; Andrew Anh Nguyen; Chad E Bigelow; Stephen Poor; Yubin Qiu; Nalini V Rangaswamy; Richard Ornberg; Brittany Jackson; Howard Mak; Tucker Ezell; Vania Kenanova; Elisa de la Cruz; Ana Carrion; Bijan Etemad-Gilbertson; Roxana Garcia Caro; Kan Zhu; Vinney George; Jirong Bai; Radhika Sharma-Nahar; Siyuan Shen; Yiqin Wang; Kulandayan K. Subramanian; Elizabeth Fassbender; Michael Maker; Shawn Hanks; Joanna Vrouvlianis; Barrett Leehy; Debby Long; Melissa Prentiss; Viral Kansara
Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently as every month. Here we report a method to extend the intravitreal half-life of protein drugs as an alternative to either encapsulation or chemical modifications with polymers. We combine a 97-amino-acid peptide of human origin that binds hyaluronan, a major macromolecular component of the eyes vitreous, with therapeutic antibodies and proteins. When administered to rabbit and monkey eyes, the half-life of the modified proteins is increased ∼3–4-fold relative to unmodified proteins. We further show that prototype long-acting anti-VEGF drugs (LAVAs) that include this peptide attenuate VEGF-induced retinal changes in animal models of neovascular retinal disease ∼3–4-fold longer than unmodified drugs. This approach has the potential to reduce the dosing frequency associated with retinal disease treatments.
Archive | 2009
Beate Diefenbach-Streiber; Adina Eberth; Braydon Charles Guild; Yong-In Kim; Michael Roguska; Igor Splawski
Archive | 2008
Braydon Charles Guild; Mark T. Brookline Keating; Mariusz Milik; Dmitri Mikhailov; Michael Roguska; Igor Splawski; Kehao Zhao
Archive | 2008
Bijan Etemad-Gilbertson; Braydon Charles Guild; Mark T. Brookline Keating; Yong-In Kim; Lloyd B. Klickstein; Dmitri Mikhailov; Mariusz Milik; Michael Roguska; Igor Splawski; Kehao Zhao
Archive | 2013
Joy Ghosh; Mark Anthony Rutz; Kathrin Ulrike Tissot-Daguette; Igor Splawski; Michael Roguska
Archive | 2012
Barbara Brannetti; Joy Ghosh; Ute Jaeger; Leslie Johnson; Yong-In Kim; Christian Carsten Silvester Kunz; Michael Roguska; Igor Splawski
Investigative Ophthalmology & Visual Science | 2016
Leslie Johnson; Igor Splawski; Lisa Baker; Ana Carrion; Anh Nguyen; Michael Twarog; Yiqin Wang; Ute Jäger; Mark T. Brookline Keating; Thaddeus P. Dryja; Michael Roguska
Archive | 2015
Joy Ghosh; Michael Roguska; Andrew Anh Nguyen; Thomas Pietzonka; Stephen Poor; Matthias Machacek; Chad E Bigelow
Archive | 2014
Joy Ghosh; Michael Roguska; Andrew Anh Nguyen; Thomas Pietzonka; Stephen Poor; Matthais Machacek; Chad E Bigelow
Investigative Ophthalmology & Visual Science | 2014
Michael Roguska; Igor Splawski; Beate Diefenbach-Streiber; Elizabeth Dolan; Bijan Etemad-Gilbertson; Jean-Michel Rondeau; Mark T. Brookline Keating