Michael S. Okun

Unilateral Focused Ultrasound Subthalamotomy for Parkinson Disease

To examine the effects of MRI-guided unilateral ultrasound subthalamotomy for Parkinson disease (PD) tremor, researchers conducted a prospective,

More Evidence Linking REM Behavioral Disorder to Parkinson Disease

The deposition and spread of aggregates of the protein α-synuclein has been evolving as an important construct underpinning our understanding of

Botulinum Toxin Injections for Bruxism: Don't Forget About the Apnea

Researchers tested onabotulinum toxin-A (BoNT-A) masseter and temporalis injections for sleep-associated bruxism in a manufacturer-funded trial. After

Truncal Vagotomy Reduces Parkinson Disease Risk

Truncal vagotomy is a surgical procedure that functionally denervates and disconnects multiple organs, including the stomach, liver, gallbladder,

Will Your Pure Autonomic Failure Patients Convert to Parkinsonism

To shed light on which cases of pure autonomic failure will convert to a synucleinopathy (Parkinson disease, dementia with Lewy bodies, or multiple system atrophy), investigators prospectively followed 74 patients from five U.S. medical centers for 5 years. Mean age was 68, there was documented pre-existing autonomic failure for a mean of 5 years. Follow-up at 4 years revealed that 25 patients (34%) had a new diagnosis of dementia with Lewy bodies (13 patients), Parkinson disease …

Are Patients Who Lose Sense of Smell at Risk for Parkinson Disease

The idea that the loss of smell could predict later diagnosis of Parkinson disease (PD) is an interesting premise, especially given the relatively

Will Virtual House Calls Change Parkinson Disease Treatment

Investigators conducted a multicenter trial to determine whether providing home visits through the use of telemedicine for Parkinson disease (PD)

Is Exenatide Neuroprotective in Parkinson Disease

Exenatide is a glucagon-like peptide-1 (GLP-1)–receptor agonist used in diabetes that has been suggested as a candidate for a disease-modifying drug in

A Risk Prediction Score for Parkinson Disease

To develop a simple, outcomes-based prognostic model for Parkinson disease (PD), researchers tested a composite outcome measure in a clinic-based group of newly diagnosed PD patients recruited for another study in the Netherlands. External validation was performed in a separate group of community-based, newly diagnosed PD patients in the United Kingdom. The primary outcome was unfavorable prognosis, defined as postural instability, dementia, or death at or …

Don't Overlook Orthostatic Tremor

To better characterize the clinical presentation, physiology, and treatment outcomes of orthostatic tremor (OT), researchers retrospectively reviewed