Michał Krzysztof Kołodziejczyk
Medical University of Łódź
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Featured researches published by Michał Krzysztof Kołodziejczyk.
Archivum Immunologiae Et Therapiae Experimentalis | 2015
Agata Kowalczyk; Paulina Kleniewska; Michał Krzysztof Kołodziejczyk; Beata Skibska; Anna Goraca
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-κB and expression of proinflammatory cytokines including TNF-α, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases. This review summarises the current knowledge regarding endothelin receptor antagonists and the role of ET-1 in sepsis and inflammation.
Reumatologia | 2018
Justyna Kołodziejska; Michał Krzysztof Kołodziejczyk
Diclofenac, a phenylacetic acid derivative, is a drug demonstrating high efficacy after oral administration in the treatment of pain and physical disability in rheumatic diseases. In view of the adverse effects associated with using diclofenac, it is necessary to consider all known drug safety information before the drug is selected for therapy and the dosage regimen is set for individual patients. Selecting an oral dosage form with specific properties determined by excipients is a method to improve the availability of the drug substance and, at the same time, minimize adverse drug reactions. An alternative to tablet or capsule dosage forms is diclofenac application to the skin. The proven efficacy of this method is further improved through the use of transdermal penetration enhancers and vehicle ingredients which provide dosage forms with specific physical properties.
Polymers in Medicine | 2017
Wojciech Andrzej Linka; Mateusz Kot; Michał Krzysztof Kołodziejczyk
BACKGROUND One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve the comfort of use. One way to obtain such effects are prolonged release dosage forms. OBJECTIVES The aim of the study was to investigate the suitability of polymers (synthetic - Kollidon K30 and semisynthetic - hydroxypropyl methylcellulose), and calcium hydrogen phosphate dihydrate - as an inorganic insoluble filler - in the construction of the matrices of the solid oral dosage forms containing non-steroidal anti-inflammatory drugs (NSAIDs). We used ketoprofen as a model active ingredient. MATERIAL AND METHODS Ketoprofenum, hydroxypropylmethylcellulose, calcium hydrogen phosphate, kollidon K30, magnesium stearate. Incorporation. Studies of the tablet mass. Direct tabletting. Studies of the pharmacopoeial parameters and pharmaceutical availability. Measurements of the viscosity of 1% solution of HPMC and Kollidon K30. Approximation of the results. RESULTS We obtained three versions (formulations) of the matrices. The results of the granulometric research on tablet formulations were consistent with the standards. The results of morphological studies and pharmacopoeial tablets were consistent with the standards. The best results were obtained for the release formulations containing HPMC and calcium hydrogenphoshate. Kollidon K30 accelerated the release of ketoprofen from tablets of formulation I. CONCLUSIONS The model system of preformulation studies showed the usefulness of HPMC and Kollidon K30 in the technology of hydrophilic matrices with ketoprofen.
Current Issues in Pharmacy and Medical Sciences | 2017
Aneta Berner-Strzelczyk; Agnieszka Jach; Justyna Kołodziejska; Michał Krzysztof Kołodziejczyk; Malgorzata Godlewska; Magdalena Piechota-Urbańska
Abstract In topical formulations, the rheological parameters and pharmaceutical availability of many active agents have been improved by the addition of modern excipients. This translates into increased interest in the topical use of NSAIDs. The aim of this study was to create series of effective oil in water (O/W) diclofenac sodium cream formulations that differ in the applied fatty phase, utilizing Gelot TM64 (Gattefosse) (a modern non-ionic emulsifier). In the produced prescriptions, estimation was made of the effect of this on the rheological parameters and the pharmaceutical availability of the diclofenac sodium. Herein, the hydrophilic petrolatum-based cream demonstrated the highest rate of release of the active agent, as well as the best set of beneficial rheological parameters.
Current Issues in Pharmacy and Medical Sciences | 2015
Adrian Głogowski; Justyna Kołodziejska; Michał Krzysztof Kołodziejczyk; Marian Mikołaj Zgoda
Abstract The aim of this study was to analyze the morphological parameters (viscosity, viscous elasticity and the rate of volatile component loss) of salicylic and boric acid-containing magisterial formulae (ointments). Moreover, the effects of these parameters on the diffusion rate of a therapeutic agent (salicylic acid) to an in vitro external compartment were analyzed. Finally, the applicatory properties of the ointments prepared by way of a conventional technique (in a mortar) and with the aid of an unguator, were compared. The rheological parameters of the analyzed ointments suggest that the preparations made with an aid of an unguator, irrespective of the physicochemical characteristics of their vehicles, are characterized by higher values of diffusion coefficient (D). In addition, conventionally-prepared formulae containing salicylic were shown to be characterized by better viscous elasticity. Surprisingly, irrespective of the preparation technique, the ointments based on an absorptive vehicle (containing lanolin) were characterized by similar viscous elasticity. The rate of volatile (water) component loss from ointments containing a 3% solution of boric acid suggests that such formulae lose no more than 2.3% of their mass when exposed at 37℃. Therefore, the viscosity of such ointments applied onto a patient’s skin should remain relatively stable.
Postȩpy higieny i medycyny doświadczalnej | 2014
Agata Kowalczyk; Michał Krzysztof Kołodziejczyk; Anna Gorąca
Endothelins are endothelial peptides, the properties of which have been investigated for over 25 years. They play a special role in the pathophysiology of many diseases of the cardiovascular system. Endothelin-1, which is the most explored one, is a potent vasoconstrictor. It increases renal water and sodium excretion, augments cell growth and proliferation and has proinflammatory activity, by intensifying the production of reactive oxygen and nitrogen species (ROS and RNS). ET-1 takes part in the progression of such diseases as hypertension, atherosclerosis, heart and renal failure. The physio- and pathological effects of endothelins are mediated through ETA and ETB receptors. Blocking these receptors, in particular the ETA receptor, can prevent negative effects of endothelins. Long-term efforts to create drugs which act like that have brought relevant results. Endothelin receptor antagonists (ERA) are a new class of medicines, which are indicated in the treatment of pulmonary arterial hypertension. There are also optimistic results of trials with ERA administered in other disorders. On the basis of these data we may conclude that there will be more indications for this group of drugs. This review discusses properties and new research directions of ERA registered in pharmacotherapy.
Polimery w medycynie | 2009
Marian Mikołaj Zgoda; Nachajski Mj; Michał Krzysztof Kołodziejczyk
Polimery w medycynie | 2007
Marian Mikołaj Zgoda; Nachajski Mj; Michał Krzysztof Kołodziejczyk; Woskowicz Mh; Lukosek M
Alergoprofil | 2018
Michał Krzysztof Kołodziejczyk; Nachajski Mj
Herba Polonica | 2016
Adrian Głogowski; Zbigniew Marczyński; Michał Krzysztof Kołodziejczyk; Jerzy Jambor; Marta Kinga Stefan; Marian Mikołaj Zgoda