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Publication
Featured researches published by Michal Uher.
The International Journal of Biochemistry & Cell Biology | 1995
Janette Bransová; Julius Brtko; Michal Uher; Ladislav Novotný
In a search for new compounds possessing antitumor activity, we examined the effects of a group of oxygen containing heterocyclic derivatives on L1210 murine leukemia cell growth. Several 5-hydroxy-2-hydroxymethyl-4-pyranone derivatives were tested in a growth assay employing a human leukemia K562 cells line. IC50 was extrapolated from the growth inhibition curves at compound concentrations ranging from 0.1 to 100 microM. The halogen derivatives of 5-hydroxy-2-hydroxymethyl-4-pyranone inhibited L1210 cell growth in suspension culture after 96 hr incubation in the following order: 5-hydroxy-2-iodomethyl-4-pyranone (IC50 3.15 microM) > 6-bromo-2-bromomethyl-5-hydroxy-4-pyranone (IC50 3.40 microM) > 6-bromo-5-hydroxy-2-hydroxy-methyl-4-pyranone (IC50 3.75 microM) > 2-bromomethyl-5-hydroxy-4-pyranone (IC50 4.30 microM) > 5-benzyloxy-2-chloromethyl-4-pyranone (IC50 5 microM) > 6-bromo-2-chloromethyl-4-pyranone (IC50 13.50 microM) > 6-chloro-2-chloromethyl-5-hydroxy-4-pyranone (IC50 18 microM) > 2-chloromethyl-5-hydroxy-4-pyranone (IC50 20 microM). The compound, 5-hydroxy-2-hydroxymethyl-4-pyranone has no effect on L1210 cell growth. These results suggest that 5-hydroxy-2-hydroxymethyl-4-pyranone derivatives might represent a new class of compounds with antileukemic activity.
Monatshefte Fur Chemie | 2000
Michal Uher; Joanna Szymońska; Anna Korenova; Piotr Tomasik
Summary. Chlorokojic acid was reacted with S2O32−, NO3−, N3−, I−, and SCN−. Only the three latter nucleophiles substituted the chlorine atom in the 2-CH2Cl group of kojic acid. In none of the products nucleophilic substitution at position 6 of the 4-pyrone could be found. Regular substituion of chlorokojic acid with I− (iodokojic acid), N3− (azidokojic acid), and SCN− (thiocyanato and isothiocyanato kojic acids) was accompanied by formation of allomaltol. Reaction pathways for the formation of allomaltol and 6-substituted allomaltol derivatives are proposed. The latter has been formerly discovered in the reaction of chlorokojic acid with secondary amines.
Phosphorus Sulfur and Silicon and The Related Elements | 2003
Bogdan Boduszek; Anna Koreňová; Michal Uher; Daniel Végh
Some new pyridone aminophosphonic acids were synthesized from pyridone aldimines and tris(trimethylsilyl)phosphite. It was found that the obtained aminophosphonic acids 2 were cleaved in mineral acid solutions to form the corresponding amines 3 and phosphoric acid. Preliminary kinetic measurements were performed.
Journal of Molecular Structure-theochem | 2004
Krzysztof Zborowski; Anna Korenova; Michal Uher; Leonard M. Proniewicz
Journal of Applied Toxicology | 2008
Maria Fickova; Eliska Pravdova; Lars Rondhal; Michal Uher; Julius Brtko
Collection of Czechoslovak Chemical Communications | 1981
Michal Uher; Dušan Ilavský; Jozef Foltín; Katarína Škvareninová
Collection of Czechoslovak Chemical Communications | 1977
L. Floch; Augustin Martvoň; Michal Uher; Ján Leško; W. Weis
Quantitative Structure-activity Relationships | 1996
Katarína Piršelová; Štefan Baláž; Regina Ujhelyová; Ernest Šturdík; Michal Uher; Julius Brtko
Collection of Czechoslovak Chemical Communications | 1993
Štefan Baláž; Ernest Šturdík; Regina Ujhelyová; Dušan Valigura; Michal Uher; Václav Konečný; Jana Adamcová; Peter Michalík; Julius Brtko
Quantitative Structure-activity Relationships | 1997
Katarína Piršelová; Štefan Baláž; Ernest Šturdík; Regina Ujhelyová; Michal Uher; Julius Brtko