Michel Broyer

Renal prostaglandin E2 in nephrogenic diabetes insipidus: Effects of inhibition of prostaglandin synthesis by indomethacin

uation o f this therapy in hospital did not obviate the need for peri toneal dialysis. Although abnormalities of coagulation have been demonstrated rarely in the HUS, 7 there is usually no evidence of ongoing disseminated intravascular coagulation in this disorder? Accordingly, there is little factual basis for anticoagulant therapy. As recommended by othersr we agree that a definite role for the use of inhibitors of platelet aggregation in the therapy of this disease must await more definitive studies clearly demonstrat ing that platelet consumption is a primary noxious event in the evolution of this syndrome.

Chronic Hypophosphatemia in Kidney Transplanted Children and Young Adults

Different mechanisms have been suggested to account for the frequently observed hypophosphatemia after renal transplantation. One may propose, along this line, the persistence of a pretransplant hyperparathyroidism1,2, the post-transplant administration of oral hydroxide antacids3, the post-transplant steroid therapy4 a deficiency in vitamin D active metabolites4,5, a tubular dysfunction6, or an abnormality in intestinal phosphate absorption7. In an attempt to analyse the respective importance of these factors, serial measurements of biochemical and radioimmunological parameters have been performed in the twelve subjects transplanted during the year 1976 in the Department of Pediatric Nephrology (Pr. M. Broyer) and considered as successful kidney transplantation.

Plasma lipids in kidney transplanted children and adolescents: influence of pubertal development, dietary intake and steroid therapy

Abstract. Plasma triglycerides and/or cholesterol were significantly increased in twenty‐four of thirty kidney transplanted children and adolescents with stable renal function, at least one year after the last rejection crisis who received low dose prednisone therapy. The cholesterol increment was related to both low density and high density lipoproteins. However, similar to findings in adult allograft recipients, these increases were very variable: six subjects had normal levels, eight had increased triglycerides, five increased triglycerides and cholesterol, and eleven increased cholesterol. No influence of renal function was found in this series of patients all of whom had plasma creatinine below 160 μmol/1. Subjects who had achieved sexual development had lower cholesterol values. An insignificant difference was observed between patients receiving daily and alternate‐day steroid therapy, but a significant negative correlation was found between plasma triglycerides and fractional urinary excretion of 17 OH corticosteroids in the first 6 h after an oral dose of prednisone. Finally, no correlation was found between energy intake and triglycerides; but a significant correlation was observed between protein intake and plasma cholesterol.

Suppressive effect of 1α -hydroxyvitamin D3 on the hyperparathyroïdism of children on maintenance hemodialysis

Abstract The effectiveness of l α-(OH)D 3 treatment on the hyperparathyroidism that occurs in children on chronic hemodialysis was investigated. In the six children studied the vitamin D analog produced marked and rapid suppression of plasma iPTH concentrations. The therapy was well tolerated and no serious side effects of the treatment were observed.