Michel Delecroix

PhysioDoloris: a monitoring device for Analgesia / Nociception balance evaluation using Heart Rate Variability analysis

Continuous Analgesia / Nociception balance evaluation during general anesthesia could be of precious help for the optimization of analgesic drugs delivery, limiting the risk of toxicity due to the use of opioid drugs, limiting the risk of post operative hyper algesia, and, probably, reducing time of recovery after surgical procedure. Heart Rate Variability analysis has been shown in several studies to measure the Autonomic Nervous System tone, which is strongly influenced by anesthetic drugs. Recording RR series during general anesthesia enabled us to observe that the Respiratory Sinus Arrhythmia pattern changed when a surgical stimulation was painful, even though the patient was not conscious. We have previously developed and evaluated a pain / analgesia measurement algorithm based on the magnitude analysis of the respiratory patterns on the RR series. In this paper, we present the development of a monitoring device (PhysioDoloris), based on the previously described technology, giving in real time an Analgesia Nociception Index (ANI) which can be used during general anesthesia in order to give to the anesthetist, a complementary tool for optimized drug delivery.

Heart rate variability analysis for arterial hypertension etiological diagnosis during surgical procedures under tourniquet

Pneumatic tourniquets are widely used to provide a bloodless operative field during upper or lower limb surgery. If tourniquet inflation during general anesthesia is initially a mild stimulus, a long duration of inflation can imply heart rate and blood pressure increasing. However, heart rate or blood pressure increasing can also be caused by other external stimuli. Indeed, in the case of an insufficient analgesia, painful surgical stimuli can also cause an increase in heart rate and blood pressure. Therefore, in the case of the use of a tourniquet during surgery, its very difficult for the anesthesiologist to distinguish hypertension caused by pain from hypertension caused by tourniquet inflation. In such a case, an efficient and reliable hypertension diagnosis could help the anesthesiologist in the medication choice. We have previously developed and evaluated an Analgesia / Nociception Index (ANI) based on the magnitude analysis of the respiratory patterns on the RR series. We hypothesize that the use of such an index could help in the arterial hypertension etiological diagnosis during surgical procedures under tourniquet.

Automated analgesic drugs delivery guided by vagal tone evaluation: Interest of the Analgesia Nociception Index (ANI).

Analgesic drugs delivery optimization constitutes one of the main objectives of modern anesthesia. Indeed, their over or under determination constitutes a risk for anesthetized patient in terms of hemodynamic reactivity or post-operative hyperalgesia. Nowadays, new physiological indexes allow anesthesiologists to evaluate the balance between the analgesia level and the noxious stimulus importance. A I is an index related to the autonomic nervous system activity based on heart rate variability analysis. Its ability for the analgesia / nociception balance evaluation has been established bringing evidences about its helpfulness for analgesic drug delivery. In this article, we describe a device for automatic analgesic drugs administration based on the A I evolution during surgical procedures under general anesthesia. We hypothesized that such a device could improve the quality and safety of anesthesia by reducing adverse cardiovascular events and delivered analgesic drugs doses.

Ambulatory pain evaluation based on heart rate variability analysis: Application to physical therapy

Pain assessment is critical for efficient pain management. Clinicians usually use self-report or behavioral pain scales. In practice, the choice of the most adaptive scale depends on several parameters like the clinical context, the patient consciousness or its age, but all evaluation scales are known to be more or less subjective and to present high inter and intra individual variability. Recently, several innovative medical devices have been developed in order to provide to the clinicians a physiological measure of pain. These technologies are mainly used for the continuous monitoring of patients in intensive care or during surgery. As an example, we have developed a heart rate variability analysis based technology for analgesia/nociception monitoring in patients undergoing surgery under general anesthesia. Even if this technology is now used in other clinical settings, the resulting device presents some mobility constraints. In this paper, we describe the adaptation of this technology to the ambulatory pain evaluation and its clinical validation in the particular context of physical therapy. In the frame of this validation, we showed the device usability and efficiency for pain evaluation during physical therapy sessions.