Michel Luong

Stacked magnetic resonators for MRI RF coils decoupling

Parallel transmission is a very promising method to tackle B1+ field inhomogeneities at ultrahigh field in magnetic resonant imaging (MRI). This technique is however limited by the mutual coupling between the radiating elements. Here we propose to solve this problem by designing a passive magneto-electric resonator that we here refer to as stacked magnetic resonator (SMR). By combining numerical and experimental methodologies, we prove that this novelty passive solution allows an efficient decoupling of elements of a phased-array coil. We demonstrate the ability of this technique to significantly reduce by more than 10dB the coupling preserving the quality of images compared to ideally isolated linear resonators on a spherical salty agar gel phantom in a 7T MRI scanner.

Probabilistic analysis of the specific absorption rate intersubject variability safety factor in parallel transmission MRI

Specific absorption rate (SAR) calculations in parallel transmission are commonly performed by using electromagnetic simulations on generic models. In this study, we propose a probabilistic analysis to study the safety factor employed to account for SAR intersubject variability versus risk relationship in head imaging at 7T.

Exposure System and Dosimetry for In Vitro Studies of Biocompatibility of Pulse-Modulated RF Signals of Ultrahigh Field MRI

A new setup for exposure of human cells in vitro at 37 °C to pulse-modulated 300 and 500 MHz signals of future magnetic resonance imaging (MRI) systems is designed, built up, and characterized. Two dipole antennas, specifically designed for ultrahigh field MRI, are used as radiating structures. The electromagnetic (EM) field distribution inside the incubator containing the cells is computed, and it is shown to be in a good agreement with measurements. The electric field at the cell level is quantified numerically. Local, 1-g average, and averaged over the culture medium volume SAR are provided along with the standard deviation values for each well. Temperature increments are measured inside the culture medium during the exposure using an optical fiber thermometer. Then, we identify the pulse parameters corresponding to the thermal threshold of 1 °C, usually considered as a threshold for thermally induced biological effects. For these parameters, the induction of heat shock proteins is assessed to biologically verify a potential thermal response of cells. The data demonstrate that, under the considered experimental conditions, exposure to pulse-modulated radiations emulating typical ultrahigh field MRI signals, corresponding to temperature increments below 1 °C, does not trigger any heat shock response in human brain cells.

Simultaneous multi-parametric mapping of total sodium concentration, T1, T2 and ADC at 7 T using a multi-contrast unbalanced SSFP

PURPOSE Quantifying multiple NMR properties of sodium could be of benefit to assess changes in cellular viability in biological tissues. A proof of concept of Quantitative Imaging using Configuration States (QuICS) based on a SSFP sequence with multiple contrasts was implemented to extract simultaneously 3D maps of applied flip angle (FA), total sodium concentration, T1, T2, and Apparent Diffusion Coefficient (ADC). METHODS A 3D Cartesian Gradient Recalled Echo (GRE) sequence was used to acquire 11 non-balanced SSFP contrasts at a 6 × 6 × 6 mm3 isotropic resolution with carefully-chosen gradient spoiling area, RF amplitude and phase cycling, with TR/TE = 20/3.2 ms and 25 averages, leading to a total acquisition time of 1 h 18 min. A least-squares fit between the measured and the analytical complex signals was performed to extract quantitative maps from a mono-exponential model. Multiple sodium phantoms with different compositions were studied to validate the ability of the method to measure sodium NMR properties in various conditions. RESULTS Flip angle maps were retrieved. Relaxation times, ADC and sodium concentrations were estimated with controlled precision below 15%, and were in accordance with measurements from established methods and literature. CONCLUSION The results illustrate the ability to retrieve sodium NMR properties maps, which is a first step toward the estimation of FA, T1, T2, concentration and ADC of 23Na for clinical research. With further optimization of the acquired QuICS contrasts, scan time could be reduced to be suitable with in vivo applications.