Michel Slim

Intubation of Pediatric Trauma Patients in the Field: Predictor of Negative Outcome Despite Risk Stratification

BACKGROUNDnRecently, evidence has shown that intubation in the field may not improve or may even adversely affect outcomes. Our objective was to analyze outcomes in pediatric intubated trauma patients using a large national pediatric trauma registry.nnnMETHODSnThe patient population was derived from the last phase of the National Pediatric Trauma Registry, comprising admissions from 1994 through 2002. Intubated patients were identified, as was their place of intubation: in the field, at a hospital that was not a trauma center, and at a trauma center. Risk stratification was performed for mortality using logistic regression models and variables available at presentation to the emergency room. Odds ratio and variable significance were calculated from the logistic regression model. The percentage of patients discharged to home and an abnormal Functional Independence Measure at hospital discharge examined functional outcome of survivors.nnnRESULTSnThere were a total of 50,199 patients, 5460 (11.6%) of whom were intubated (1,930 in the field, 1,654 in the hospital, and 1,876 in a trauma center). Unadjusted mortality rates for intubated patients were as follows: field, 38.5%; hospital, 16.7%; and trauma center, 13.2% (all different, p < 0.05). The developed logistic regression model had an area under the receiver operating characteristic curve of 0.98. Compared with nonintubated patients, the odds ratio for field intubation, for non-trauma center, and for trauma center intubation was 14.4, 5.8, and 4.8, respectively (significantly different field vs. either hospital). The actual (observed) death rate was significantly higher than predicted in those intubated in the field. Stratification of injury by New Injury Severity Score or degree of head injury showed that this difference extended from mild to severe (e.g., odds ratio for New Injury Severity Score < 15 field vs. trauma center intubation, 12.3; odds ratio for none or moderate head injury, 5.1). Similar results were obtained for functional outcome in the survivors.nnnCONCLUSIONnField intubation is an independent strong negative predictor of survival or good functional outcome despite adjustment for severity of injury. Although not causal, the magnitude of these differences should lead to future controlled studies of pediatric trauma field intubations.

Prediction of mortality in pediatric trauma patients: new injury severity score outperforms injury severity score in the severely injured.

BACKGROUNDnThe Injury Severity Score (ISS) is a widely accepted method of measuring severity of traumatic injury. A modification has been proposed--the New Injury Severity Score (NISS). This has been shown to predict mortality better in adult trauma patients, but it had no predictive benefit in pediatric patients. The aim of this study was to determine whether the NISS outperforms the ISS in a large pediatric trauma population.nnnMETHODSnAdmissions in the National Pediatric Trauma Registry between April 1996 and September 1999 were included. The ISS and NISS were calculated for each patient. The study endpoints were mortality at hospital discharge, functional outcome in three domains (expression, locomotion, and feeding), and discharge disposition for the survivors. Predictive ability of each score was assessed by area under the receiver operating characteristic curve.nnnRESULTSnThe NISS and ISS performed equally well at predicting mortality in patients with lower injury severity (ISS < 25), but the NISS was significantly better at predicting mortality in the more severely injured patients. Both scores performed equally well at predicting expression and feeding ability. The NISS was superior to the ISS in predicting locomotion ability at discharge. Thirty-seven percent of patients had an NISS that was higher than their ISS. These patients had a significantly higher mortality and suffered worse functional outcomes.nnnCONCLUSIONnThe NISS performs as well as the ISS in pediatric patients with lower injury severity and outperforms the ISS in those with higher injury severity.

Hydatid disease in childhood

Summary This review of 370 cases of hydatid disease reveals that 34 of the patients were under 15 yr of age. In these children, the organ most frequently involved was the lung (65%) but multiple organ involvement, noted in 8% of the adults, was absent. Children comprised 43% of the patients with hydatidosis of the brain, 15% of those with cysts in the lung, and 3% of those with cysts in the liver. Of the eight children for whom the three serological tests (Casoni, Weinberg, and indirect hemagglutination) were done, six showed negative reactions to all three tests. In four cases, errors were made in diagnosis and the children, on operation, proved to have hydatid cysts of the lung in two cases, of the liver in the third, and of the kidney in the fourth. Correct diagnosis calls for a combination of the three serological tests and radiological procedures. The treatment of hydatidosis should include the prevention of spillage of untreated hydatid fluid into the surrounding tissues the use of scolecidal agents, and resection. Frequent postoperative physical checkups are recommended.

Double zonal aganglionosis in long segment Hirschsprung's disease with a “skip area” in transverse colon

The case of an infant with Hirschsprungs disease involving the rectum, entire colon, cecum, appendix, terminal ileum and sparing the midtransverse colon is described. The purpose of the report is to submit an additional illustration of this rarely documented aspect of intestinal aganglionosis.

Diagnostic imaging in the follow-up of nonoperative management of splenic trauma in children

Abstract.The spleen is the most frequently injured organ in blunt abdominal trauma (BAT). Contrast-enhanced computed tomography (CT) is approximately 95% sensitive and specific for detection of splenic injury. In children, nonoperative treatment is well-established. The basic tenet of such management is an obligatory period of rest to prevent recurrent bleeding and allow splenic healing. Splenic preservation prevents post-splenectomy sepsis. At our level I trauma center, pediatric patients (N=54) with BAT between 1993 and 1998 were retrospectively studied. Two (3.7%) died of associated injuries; 2 underwent splenectomy before transfer to our hospital. All had been diagnosed with splenic injury by CT. The mean age was 11.3 years. The mechanisms of injury were motor vehicle accidents (66%), bicycle accidents (26%), and falls (8%). All 50 remaining patients were followed by ultrasound (US) after the initial diagnosis by CT. The mean hospital stay was 6 days. One patient developed the rare complication of an arterio venous (AV) fistula within the damaged spleen; 47 (94%) had normal, homogeneous parenchymal echogenicity at healing (including the patient with the AV fistula). The remaining 3 demonstrated a visible echogenic scar. Imaging documentation of healing blunt splenic trauma should ideally minimize cost and relative risk. Our results add further evidence that US is well-suited to the task. No delayed complications with this approach were recorded in this series.

Primary repair of colorectal injuries in childhood

A retrospective survey of 44 children with colorectal perforating injuries secondary to shrapnel and high velocity bullets is presented. Seven patients had the injury limited to the colon or rectum. All patients were operated upon within 7 hr from the their colonic wounds and 20 underwent a colostomy. Five of the patients repaired primarily had their injuries to the left side of the colon or rectum. None of the patients undergoing primary repair suffered from an anastomotic leak. The mortality rate after primary repair was 16.6% and after colostomy 10%. The mortality was significantly different in the group of patients who had additional injuries where a colostomy procedure was associated with a lower mortality rate (11% versus 21%). Shock on admission and during operation affected survival adversely in all patients. The average hospital stay of survivors was 24 days with primary repair and 36 days with colostomy.

Neuroblastoma: Report on a 21-year experience

This is a review of 80 patients with neuroblastoma managed at the American University of Beirut Medical Center between 1963 and 1983. Three patients had ganglioneuroblastoma of whom one showed histologic evidence of maturation into a ganglioneuroma. Four patients were less than 1 month of age and 33 were less than 2 years of age. The site of origin was intra-abdominal in 56 patients of whom 34 were intra-adrenal. Intraspinal involvement was noted in 12 patients, of whom one was a newborn. Treatment and adequate follow-up were possible in 63 patients. Total excision of the tumor was performed in 17 patients, and partial excision in 14. The 2-year and 5-year survival rates were 36% and 25%, respectively. Age, site of the tumor, and degree of cellular differentiation were the only independent variables affecting survival. Eleven of 14 patients younger than 1 year were alive 5 or more years after diagnosis. Cervical, thoracic, and pelvic tumors had a better prognosis than abdominal tumors. Other factors affecting survival were the stage and the mode of therapy. Infants with stage IV-S congenital neuroblastoma had a very poor prognosis. The initial urinary VMA level as well as the presence or absence of calcifications within the tumor had no bearing on prognosis.

HIV-associated (non-thymic) intrathoracic lymphoepithelial cyst in a child.

Abstract An unusual case of a juxtabronchial lymphoepithelial cyst in an HIV-positive child with post-obstructive pneumonia is presented. The pathogenesis and similarity with parotid lymphoepithelial cysts is discussed.