Michelle Mishoe

Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy

Background:  Approximately two‐thirds of egg‐allergic infants become tolerant within the first 5 years of life.

Partially Hydrolyzed Whey Formula Intolerance in Cow's Milk Allergic Patients

class, may differ in immune reactivity only for the characteristics of the side chains. Thus, the reactivity of the immune system to one compound of one drug class may result in unexpected cross-reactivity to similar compounds. This crossreactivity of the immune system with similar drugs depends on the structural affinity and precursor frequency of drug-specific T (or B) cells. Drugs, which may differ in only an OH group, might be result more cross-reactive than drugs which are different in a longer side chain (9). Cross-reactivity in IgEmediated reactions is more problematic, since in sensitized individuals, small amounts of drugs (which normally behave as haptens) may induced a cross-link drug-specific IgE on mast cells by hapten-carrier complexes. Therefore, acute symptoms reflecting cross-reactivity may arise even if the amount of drug is very low and the level of cross-reactivity is limited and restricted to a small part of drug-specific IgE. Other studies would be needed about possible cross-reactivity of midazolam with other drugs or other substances occurring in nature (10).This case also confirms that skin reactivity persists for a longer period than circulating IgE, and is therefore more sensitive. In conclusion, this case demonstrates that midazolam can induce hypersensitivity reactions. Accordingly, we advise that this possibility should be considered when midazolam is administered during perioperative period in pediatric patients even if the clinical history is not indicative.

Compounds isolated from Qu Mai (Dianthus superbus) inhibit IgE secretion by human B cells

Trabajo presentado al American Academy of Allergy, Asthma and Immunology Annual Meeting celebrado en Nueva Orlenas (US) del 26 de febrero al 2 de marzo de 2010.