Michiaki Hiroe
Mie University
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Publication
Featured researches published by Michiaki Hiroe.
International Journal of Cardiology | 2013
Toshihiro Nozato; Akira Sato; Shunsuke Hirose; Hiroyuki Hikita; Atsushi Takahashi; Hisako Endo; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Kazutaka Aonuma; Michiaki Hiroe
prognostic biomarkerof type B acute aortic dissection Toshihiro Nozato , Akira Sato ⁎, Shunsuke Hirose , Hiroyuki Hikita , Atsushi Takahashi , Hisako Endo , Kyoko Imanaka-Yoshida , Toshimichi Yoshida , Kazutaka Aonuma , Michiaki Hiroe d,e a Cardiovascular Center, Yokosuka Kyosai Hospital, 1–16 Yonegahamadori, Yokosuka, Japan b Cardiovascular Division, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan c Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Japan d Mie University Research Center for Matrix Biology, Tsu, Mie, Japan e Department of Cardiology, National Center of Global Health and Medicine, Tokyo, Japan f Department of Pathology, National Center of Global Health and Medicine, Tokyo, Japan
Cardiovascular Research | 2018
Taizo Kimura; Kazuko Tajiri; Akira Sato; Satoshi Sakai; Zheng Wang; Toshimichi Yoshida; Toshimitsu Uede; Michiaki Hiroe; Kazutaka Aonuma; Masaki Ieda; Kyoko Imanaka-Yoshida
AIMS Tenascin-C (TN-C) is an extracellular matrix protein undetected in the normal adult heart, but expressed in several heart diseases associated with inflammation. We previously reported that serum TN-C levels of myocardial infarction (MI) patients were elevated during the acute stage, and that patients with high peak TN-C levels were at high risk of left ventricular (LV) remodelling and poor outcome, suggesting that TN-C could play a significant role in the progression of ventricular remodelling. However, the detailed molecular mechanisms associated with this process remain unknown. We aimed to elucidate the role and underlying mechanisms associated with TN-C in adverse remodelling after MI. METHODS AND RESULTS MI was induced by permanent ligation of the coronary artery of TN-C knockout (TN-C-KO) and wild type (WT) mice. In WT mice, TN-C was expressed at the borders between intact and necrotic areas, with a peak at 3 days post-MI and observed in the immediate vicinity of infiltrating macrophages. TN-C-KO mice were protected from ventricular adverse remodelling as evidenced by a higher LV ejection fraction as compared with WT mice (19.0 ± 6.3% vs. 10.6 ± 4.4%; P < 0.001) at 3 months post-MI. During the acute phase, flow-cytometric analyses showed a decrease in F4/80+CD206lowCD45+ M1 macrophages and an increase in F4/80+CD206highCD45+ M2 macrophages in the TN-C-KO heart. To clarify the role of TN-C on macrophage polarization, we examined the direct effect of TN-C on bone marrow-derived macrophages in culture, observing that TN-C promoted macrophage shifting into an M1 phenotype via Toll-like receptor 4 (TLR4). Under M2-skewing conditions, TN-C suppressed the expression of interferon regulatory factor 4, a key transcription factor that controls M2-macrophage polarization, via TLR4, thereby inhibiting M2 polarization. CONCLUSION These results suggested that TN-C accelerates LV remodelling after MI, at least in part, by modulating M1/M2-macrophage polarization.
Histology and Histopathology | 2004
Kyoko Imanaka-Yoshida; Michiaki Hiroe; Toshimichi Yoshida
Heart and Vessels | 1997
Hiroshi Ito; David Bell; Mimi Tamamori; Toshihiro Nozato; Takashi Shimojo; Susumu Adachi; Shizue Abe; Fumiaki Marumo; Michiaki Hiroe
Journal of Nuclear Cardiology | 2005
Marco Mazzanti; M. Marini; M. Serenelli; G.P. Perna; Akiyoshi Hashimoto; Nobuaki Kokubu; Kimio Nishizato; Satoshi Yuda; Kikuya Uno; Tomoaki Nakata; Kazufumi Tsuchihashi; Kazuaki Shimamoto; Kazuo Nagao; Tomoo Takada; Akira Sato; Kazutaka Aonuma; Toshihiro Nozato; Yoshiaki Yokoyama; Akimitsu Takahashi; M. Isobe; Michiaki Hiroe; G. De Leon; J. Rodes-Cabau; Jaume Candell-Riera; Santiago Aguadé-Bruix; Joan Castell-Conesa; Juan Angel; Adriana Soto; Inocencio Anivarro; Jean-Claude Tardif
Heart and Vessels | 1997
Hiroshi Ito; David Bell; Mimi Tamamori; Toshihiro Nozato; Takashi Shimojo; Susumu Adachi; Shizue Abe; Fumiaki Marumo; Michiaki Hiroe
Archive | 2010
Fumiaki Marumo; Katsutoshi Yamakawa; Nobuyuki Kobayashi; Takashi Shimojo; Shinji Abe; Hiroyuki Fujisaki; Shigeru Ishiyama; Michiaki Hiroe; Toshio Nishikawa
Archive | 2010
Fumiaki Marumo; Hisao Ito; Yukio Hirata; Michiaki Hiroe; Motoyoshi Tsujino; Shinji Adachi; Takeshi Takamoto; Masao Nitta; Katsutoshi Taniguchi
Archive | 2010
Yoshito Iesaka; Michiaki Hiroe; Shigeyuki Nishimura; Yasuteru Yamauchi; Kazutaka Aonuma; Masahiko Goya; Akihiko Nogami; Shigeto Naito; Hiroshi Tada; Koichi Taniguchi; Yoshihiro Okamoto
Journal of Nuclear Cardiology | 2007
Akira Sato; Michiaki Hiroe; Mieko Tamura; K. Ohigashi; Yusuke Ito; Toshihiro Nozato; Hiroyuki Hikita; Akimitsu Takahashi