Michihiro Nose

Accessory parotid gland tumor: a case report

We report a case of pleomorphic adenoma which was assessed pre-operatively as arising from the accessory parotid gland. Computed tomography (CT)-sialography provided information about the relationship between the tumor and the remaining normal accessory parotid tissue, and fine-needle aspiration of the tumor provided additional information as to the histologic features of the tumor, i.e. it was identified as of salivary origin. Zygomatic and buccal branches of the facial nerve extended over the accessory parotid gland tumor and the parotid duct was located just beneath the tumor. Therefore, pre-operative assessment of the tumors nature was important for prevention of facial nerve damage and salivary fistula. The normal accessory parotid gland tissue associated with the accessory parotid tumor was histologically different from that of normal parotid gland tissue dissected in other patients with pleomorphic adenoma of the parotid gland. It is suggested that the difference in cell composition between these glands affects the development of the associated tumors.

Nasal mucociliary clearance in patients with upper and lower respiratory diseases.

The nasal mucociliary clearance was measured in 71 subjects with nasal allergy (NA) (56 subjects without sinusitis and 15 with sinusitis), 12 subjects with bronchial asthma (BA) (7 without, 5 with) and 7 subjects with aspirin-induced asthma (AIA) using a saccharin test. The results were compared with those obtained in a control group of 15 healthy subjects. The saccharin time (ST) values for both NA and BA subjects without sinusitis (16.9 +/- 9.9 and 20.1 +/- 9.4 min, respectively) did not differ from that of the healthy subjects (16.3 +/- 5.3 min). However, ST values in NA and BA subjects with sinusitis (37.6 +/- 22.9 and 57.0 +/- 6.7 min, respectively) were significantly higher than those of healthy subjects (p < 0.01). The ST value of AIA subjects (13.0 +/- 5.4 min) showed no significant difference compared with that of the control group. These results suggest that allergic reactions do not influence the nasal mucociliary clearance and that the property of mucus complicated with sinusitis is important. Also, sinusitis observed in AIA may be somewhat different from ordinary sinusitis complicated with NA and BA.

Nasal Mucociliary Clearance in Upper and Lower Respiratory Tract Diseases.

The saccharine test was used to measure nasal mucociliary clearance in 71 patients with nasal allergy (56 without and 15 with chronic sinusitis), 12 patients with asthma (7 without and 5 with chronic sinusitis) and 7 patients with aspirin-induced asthma. The results were compared with those of a control group of 15 healthy subjects. The saccharine time (ST) in patients with nasal allergy without chronic sinusitis (16.9±9.9min) and in those with asthma without chronic sinusitis (20.1±9.4min) did not differ not significantly from that in the healthy subjects (16.3±5.3mm). But the ST in patients with nasal allergy and chronic sinusitis (37.6±22.9min) and in those with asthma and chronic sinusitis (57.0±6.7min) was significantry longr than in the controls (p<0.01). The ST in aspirin induced asthma (13.0±5.4min) was not higher than the ST in the control group. These results suggest that allergic reactions in patients with allergic diseases do not affect nasal mucociliary clearance and that the nature of the mucus and the relationship between ciliary movement and the mucus layer are important in nasal mucociliary clearance.

Flow Cytometric Analysis of Nuclear DNA Content in Head and Neck Tumors.

The nuclear DNA content of head and neck tumors (57 malignant, 20 benign) was determined by flow cytometory (FC M).We used fresh specimens and analyzed the ploidy pattern, S phase fraction and G2M phase fraction. Twenty-six of the 57 (45.6%) malignant tumors were aneuploid and all the benign tumors were diploid. Recurrent tumors tended to be aneuploid.DNA indices of the recurrent tumors were higher than those of the fresh tumors (p<0.01).The S phase fraction of diploid malignant tumors were larger than that of benign tumors (p<0.001).There was no difference in the G2M phase fraction between malignant and benign tumors.

Nasal Mucosal Hemodynamics in Nasal Allergy. Effect of Various Drugs.

Adrenaline, ipratropium or fenoterol was applied to one nasal cavity of patients with nasal allergy. The nasal mucosal blood volume (IHb) of both sides was measured with a tissue spectrum analyzer (TS-200, Sumitomo Electric Co. Ltd.) before and 5 min. after the application of the drugs.I) Unilateral application of adrenaline (0.01mg/ml, 0.12ml) decreased the IHb on the ipsilateral side but caused no change of the IHb on the contralateral side.II) Unilateral application of 20μg of ipratropium induced no change of IHb on either side.III) Unilateral application of 0.2mg or 0.4mg of fenoterol induced no change of IHb on either side.IV) Fenoterol (0.2mg) caused no significant difference in the IHb of patients with or without symptoms.V) In the patients treated with fenoterol (0.2mg), there was no significant difference of IHb between those who always used topical steroid and those who did not.These results suggest that the nasal mucosal capacitance vessels of patients with nasal allergy respond more to a-adrenergic stimulants than to β-adrenergic stimulants or anticholinergic agents.

Nasal Mucosal Hemodynamics in Nasal Allergy.

Although nasal mucosal hemodynamics in nasal allergy has been studied by various methods, it is still obscure. Using a tissue spectrum analyzer, we measured ISO2 and IHb in the nasal mucosa of patients with nasal allergy. ISO2 and IHbindicate O2 saturation in hemoglobin and tissue blood volume, respectively.i) In general, little difference in ISO2 or IHb was found beween patients with symptoms and patients without symptoms.ii) IHb in patients with perennial nasal allergy seemed to decrease when they had symptoms. On the other hand, IHb in patients with seasonal nasal allergy seemed to increase when they had symptoms.iii) In three patients with Japanese cedar pollinosis, IHb was increased during the season and was decreased at other times.