Michitaka Yajima

Delayed testosterone replacement restores nitric oxide synthase-containing nerve fibres and the erectile response in rat penis

Objective To elucidate the effect of testosterone on penile innervation.

Pericentric inversion with a minute deletion of the Y chromosome in a severely oligozoospermic man.

An apparent pericentric inversion of the Y chromosome in a severely oligozoospermic infertile patient is described. The karyotype was 46,X,inv (Y) (p11.2 q11.23). DNA analysis, however, revealed a deletion involving nine loci within the most distal part of the euchromatic region of the long arm.

Diagnostic Magnetic Resonance-Urography in an Infant Girl with an Ectopic Ureter Associated with a Poorly Functioning Segment of a Duplicated Collecting System

We report on a case of an ectopic ureter associated with a duplicated collecting system in a 6‐month‐old girl. Results of conventional imaging and endoscopic studies, including intravenous pyelography, ultrasonography of the kidneys, cystoscopy, vaginoscopy, and vaginogram, were unremarkable. An ectopic ureter, extending from a poorly functioning upper pole of the ipsilateral duplicated kidney to its vaginal opening, was visible on the magnetic resonance‐urogram. The imaging time was not extensive, and the need for patient sedation was minimal. Respiratory motion and intestinal gas did not interfere with the quality of the images. Magnetic resonance‐urography may possibly be used as a primary diagnostic method for this anomaly when it is not detected by standard imaging techniques, or as a noninvasive substitute for some interventional studies in infants.

POLYMERASE CHAIN REACTION ANALYSIS OF THE Y CHROMOSOME LONG ARM IN AZOOSPERMIC PATIENTS : LACK OF THE Y CHROMOSOME RECOGNITION MOTIF (YRRM1) GENE

We analyzed DNA from a patient with azoospermia whose Y chromosome was cytogenetically normal. A total of 16 loci on the Y chromosome long arm were examined: 15 loci between DYS7E and DYZ1, and the Y chromosome RNA recognition motif (YRRM1) locus, a candidate gene for the azoospermic factor AZF. We did not detect the YRRM1 gene in this patient. This finding supports the theory that YRRM1 is an essential gene for spermatogenesis.